Autologous T cells expressing the oncogenic transcription factor KLF6-SV1 prevent apoptosis of chronic lymphocytic leukemia cells

Crosstalk between leukemic cells and the tumor microenvironment is of importance in chronic lymphocytic leukemia (CLL). T cells seem to sustain the survival of CLL cells by various mechanisms. The Krüppel-like family of transcription factors (KLFs) are identified as regulators of proliferation and c...

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Veröffentlicht in:	PloS one 2018-02, Vol.13 (2), p.e0192839-e0192839
Hauptverfasser:	Kokhaei, Parviz, Hojjat-Farsangi, Mohammad, Mozaffari, Fariba, Moshfegh, Ali, Pak, Fatemeh, Rashidy-Pour, Ali, Palma, Marzia, Hansson, Lotta, Österborg, Anders, Mellstedt, Håkan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Apoptosis Biology and Life Sciences Cancer research Cancer therapies Cell death Cell survival Chronic lymphocytic leukemia Cloning Crosstalk Development and progression Gastric cancer Gene expression Gene therapy Growth factors Health aspects Hematology Immunology Laboratories Leukemia Lymphatic leukemia Lymphocyte receptors Lymphocytes Lymphocytes T Medical prognosis Medical research Medicin och hälsovetenskap Medicine and Health Sciences Metastasis Multiple myeloma Oncology Pathology Patients Physiology Prostate Regulators Research and analysis methods Ribonucleic acid RNA RNA-mediated interference siRNA Stomach cancer Survival T cells Transcription factors Transfection
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