Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancer

Constitutive activation of interferon signaling pathways has been reported in colorectal cancer (CRC), leading to a strong CD8+ T cell response through stimulation of NLRC5 expression. Primed CD8+ T cell expansion, however, may be negatively regulated by PD-L1 expression. Additionally, aberrant PD-L...

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Veröffentlicht in:	PloS one 2018-02, Vol.13 (2), p.e0192385-e0192385
Hauptverfasser:	Catalano, Calogerina, da Silva Filho, Miguel Inacio, Frank, Christoph, Jiraskova, Katerina, Vymetalkova, Veronika, Levy, Miroslav, Liska, Vaclav, Vycital, Ondrej, Naccarati, Alessio, Vodickova, Ludmila, Hemminki, Kari, Vodicka, Pavel, Weber, Alexander N R, Försti, Asta
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Binding sites Biological response modifiers Biology and Life Sciences Cancer Cancer and Oncology Cancer och onkologi CD8 antigen Clinical Medicine Colorectal cancer Colorectal carcinoma Development and progression Etiology Gene expression Gene polymorphism Gene regulation Genes Genetic diversity Genetic polymorphisms Genetic variance Health aspects Health risks Immunoregulation Immunotherapy Interferon Investigations Klinisk medicin Lymphocytes T Medical and Health Sciences Medicin och hälsovetenskap Medicine and Health Sciences miRNA PD-1 protein PD-L1 protein Polymorphism Rectum Regression analysis Ribonucleic acid Risk Risk factors Risk management RNA Signaling Single-nucleotide polymorphism Statistical analysis T cells Transcription (Genetics)
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