RBFOX3/NeuN is dispensable for visual function
RBFOX3/NeuN is a neuronal splicing regulator involved in neural circuitry balance, as well as neurogenesis and synaptogenesis. Rbfox3 is expressed in neurons; however, in the retina, expression is restricted to cells in the ganglion cell layer and some cells of the inner nuclear layer. Rbfox3 is exp...
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| creator | Lin, Yi-Sian Kuo, Kuan-Ting Chen, Shih-Kuo Huang, Hsien-Sung |
| description | RBFOX3/NeuN is a neuronal splicing regulator involved in neural circuitry balance, as well as neurogenesis and synaptogenesis. Rbfox3 is expressed in neurons; however, in the retina, expression is restricted to cells in the ganglion cell layer and some cells of the inner nuclear layer. Rbfox3 is expressed in a layer-specific manner in the retina, which implies a functional role, however, the role of RBFOX3 in the retina is unknown. Rbfox3 homozygous knockout (Rbfox3-/-) mice exhibit deficits in visual learning; therefore, understanding the role of RBFOX3 in the retina is critical for interpreting behavioral results. We found Rbfox3 expression was developmentally regulated in the retina and specifically expressed in ganglion cells, amacrine cells and horizontal cells of the retina. We demonstrate deletion of Rbfox3 resulted in a reduction in the thickness of the inner plexiform layer of the retina, where synapses are formed. Number of ganglion cells and amacrine cells is normal with loss of Rbfox3. Innervation of retinal ganglion cells into their targeted brain regions is normal in Rbfox3-/- mice. Importantly, Rbfox3-/- mice displayed normal non-image and image forming functions. Taken together, our results suggest RBFOX3 is dispensable for visual function. |
| doi_str_mv | 10.1371/journal.pone.0192355 |
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Rbfox3 is expressed in neurons; however, in the retina, expression is restricted to cells in the ganglion cell layer and some cells of the inner nuclear layer. Rbfox3 is expressed in a layer-specific manner in the retina, which implies a functional role, however, the role of RBFOX3 in the retina is unknown. Rbfox3 homozygous knockout (Rbfox3-/-) mice exhibit deficits in visual learning; therefore, understanding the role of RBFOX3 in the retina is critical for interpreting behavioral results. We found Rbfox3 expression was developmentally regulated in the retina and specifically expressed in ganglion cells, amacrine cells and horizontal cells of the retina. We demonstrate deletion of Rbfox3 resulted in a reduction in the thickness of the inner plexiform layer of the retina, where synapses are formed. Number of ganglion cells and amacrine cells is normal with loss of Rbfox3. Innervation of retinal ganglion cells into their targeted brain regions is normal in Rbfox3-/- mice. Importantly, Rbfox3-/- mice displayed normal non-image and image forming functions. Taken together, our results suggest RBFOX3 is dispensable for visual function.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0192355</identifier><identifier>PMID: 29401485</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amacrine cells ; Animals ; Behavior, Animal ; Biology and Life Sciences ; Brain ; Circuits ; Clonal deletion ; Gene expression ; Genetic aspects ; Health aspects ; Horizontal cells ; Immunoglobulins ; Innervation ; Life sciences ; Light ; Medicine ; Medicine and Health Sciences ; Mice ; Mice, Knockout ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - physiology ; Neural networks ; Neurogenesis ; Neurosciences ; Nuclear Proteins - genetics ; Nuclear Proteins - physiology ; Proteins ; Regulatory genes ; Research and Analysis Methods ; Retina ; Retinal ganglion cells ; Rodents ; Social Sciences ; Splicing ; Synapses ; Synaptogenesis ; Vision ; Vision, Ocular - physiology ; Visual discrimination learning ; Visual perception</subject><ispartof>PloS one, 2018-02, Vol.13 (2), p.e0192355-e0192355</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Lin et al 2018 Lin et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-74dd1fcdd218bffb80ec5f4b86e9cfe84a7f6ca3904956113c49924297a7fe273</citedby><cites>FETCH-LOGICAL-c692t-74dd1fcdd218bffb80ec5f4b86e9cfe84a7f6ca3904956113c49924297a7fe273</cites><orcidid>0000-0003-2657-3635</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798780/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798780/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29401485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Badea, Tudor C.</contributor><creatorcontrib>Lin, Yi-Sian</creatorcontrib><creatorcontrib>Kuo, Kuan-Ting</creatorcontrib><creatorcontrib>Chen, Shih-Kuo</creatorcontrib><creatorcontrib>Huang, Hsien-Sung</creatorcontrib><title>RBFOX3/NeuN is dispensable for visual function</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>RBFOX3/NeuN is a neuronal splicing regulator involved in neural circuitry balance, as well as neurogenesis and synaptogenesis. Rbfox3 is expressed in neurons; however, in the retina, expression is restricted to cells in the ganglion cell layer and some cells of the inner nuclear layer. Rbfox3 is expressed in a layer-specific manner in the retina, which implies a functional role, however, the role of RBFOX3 in the retina is unknown. Rbfox3 homozygous knockout (Rbfox3-/-) mice exhibit deficits in visual learning; therefore, understanding the role of RBFOX3 in the retina is critical for interpreting behavioral results. We found Rbfox3 expression was developmentally regulated in the retina and specifically expressed in ganglion cells, amacrine cells and horizontal cells of the retina. We demonstrate deletion of Rbfox3 resulted in a reduction in the thickness of the inner plexiform layer of the retina, where synapses are formed. Number of ganglion cells and amacrine cells is normal with loss of Rbfox3. Innervation of retinal ganglion cells into their targeted brain regions is normal in Rbfox3-/- mice. Importantly, Rbfox3-/- mice displayed normal non-image and image forming functions. Taken together, our results suggest RBFOX3 is dispensable for visual function.</description><subject>Amacrine cells</subject><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Biology and Life Sciences</subject><subject>Brain</subject><subject>Circuits</subject><subject>Clonal deletion</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Horizontal cells</subject><subject>Immunoglobulins</subject><subject>Innervation</subject><subject>Life sciences</subject><subject>Light</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Neural networks</subject><subject>Neurogenesis</subject><subject>Neurosciences</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - physiology</subject><subject>Proteins</subject><subject>Regulatory genes</subject><subject>Research and Analysis Methods</subject><subject>Retina</subject><subject>Retinal ganglion cells</subject><subject>Rodents</subject><subject>Social Sciences</subject><subject>Splicing</subject><subject>Synapses</subject><subject>Synaptogenesis</subject><subject>Vision</subject><subject>Vision, Ocular - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Yi-Sian</au><au>Kuo, Kuan-Ting</au><au>Chen, Shih-Kuo</au><au>Huang, Hsien-Sung</au><au>Badea, Tudor C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RBFOX3/NeuN is dispensable for visual function</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-02-05</date><risdate>2018</risdate><volume>13</volume><issue>2</issue><spage>e0192355</spage><epage>e0192355</epage><pages>e0192355-e0192355</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>RBFOX3/NeuN is a neuronal splicing regulator involved in neural circuitry balance, as well as neurogenesis and synaptogenesis. Rbfox3 is expressed in neurons; however, in the retina, expression is restricted to cells in the ganglion cell layer and some cells of the inner nuclear layer. Rbfox3 is expressed in a layer-specific manner in the retina, which implies a functional role, however, the role of RBFOX3 in the retina is unknown. Rbfox3 homozygous knockout (Rbfox3-/-) mice exhibit deficits in visual learning; therefore, understanding the role of RBFOX3 in the retina is critical for interpreting behavioral results. We found Rbfox3 expression was developmentally regulated in the retina and specifically expressed in ganglion cells, amacrine cells and horizontal cells of the retina. We demonstrate deletion of Rbfox3 resulted in a reduction in the thickness of the inner plexiform layer of the retina, where synapses are formed. Number of ganglion cells and amacrine cells is normal with loss of Rbfox3. Innervation of retinal ganglion cells into their targeted brain regions is normal in Rbfox3-/- mice. Importantly, Rbfox3-/- mice displayed normal non-image and image forming functions. Taken together, our results suggest RBFOX3 is dispensable for visual function.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29401485</pmid><doi>10.1371/journal.pone.0192355</doi><tpages>e0192355</tpages><orcidid>https://orcid.org/0000-0003-2657-3635</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Amacrine cells Animals Behavior, Animal Biology and Life Sciences Brain Circuits Clonal deletion Gene expression Genetic aspects Health aspects Horizontal cells Immunoglobulins Innervation Life sciences Light Medicine Medicine and Health Sciences Mice Mice, Knockout Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Neural networks Neurogenesis Neurosciences Nuclear Proteins - genetics Nuclear Proteins - physiology Proteins Regulatory genes Research and Analysis Methods Retina Retinal ganglion cells Rodents Social Sciences Splicing Synapses Synaptogenesis Vision Vision, Ocular - physiology Visual discrimination learning Visual perception |
| title | RBFOX3/NeuN is dispensable for visual function |
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