XRCC3 Thr241Met and TYMS variable number tandem repeat polymorphisms are associated with time-to-metastasis in colorectal cancer

Metastasis is a major cause of mortality in cancer. Identifying prognostic factors that distinguish patients who will experience metastasis in the short-term and those that will be free of metastasis in the long-term is of particular interest in current medical research. The objective of this study...

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Veröffentlicht in:	PloS one 2018-02, Vol.13 (2), p.e0192316-e0192316
Hauptverfasser:	He, Yanjing, Penney, Michelle E, Negandhi, Amit A, Parfrey, Patrick S, Savas, Sevtap, Yilmaz, Yildiz E
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biology and Life Sciences Canada Cancer Cancer metastasis Cancer research Chemotherapy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology DNA repair DNA-Binding Proteins - genetics Ethics Gene expression Genetic aspects Genetic polymorphisms Genetics Genomics Genotype & phenotype Genotypes Health risk assessment Health risks Humans Medical diagnosis Medical prognosis Medical research Medicine Medicine and Health Sciences Metastases Metastasis Methionine - genetics Microsatellite instability Model accuracy Mortality Neoplasm Metastasis Patients Polymorphism, Single Nucleotide Precision medicine Prognosis Single-nucleotide polymorphism Stability Systematic review Threonine - genetics Thymidylate Synthase - genetics Tumors
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