Association between meibomian gland dysfunction and compliance of topical prostaglandin analogs in patients with normal tension glaucoma
The aim of this study was to investigate the association between tear film and meibomian gland parameters in patients with normal tension glaucoma (NTG), who underwent topical prostaglandin analog (PGA) monotherapy, and medication compliance. Ocular surface disease index (OSDI), Schirmer's test...
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| description | The aim of this study was to investigate the association between tear film and meibomian gland parameters in patients with normal tension glaucoma (NTG), who underwent topical prostaglandin analog (PGA) monotherapy, and medication compliance.
Ocular surface disease index (OSDI), Schirmer's test, tear film break-up time (TBUT), keratoepitheliopathy (KEP) score with fluorescein, and meibomian gland parameters were assessed in 45 eyes of 45 patients with NTG (NTG group), who received topical PGA monotherapy for more than 1 year. The results were compared to those of 40 eyes of 40 normal subjects (control group). Medication compliance was assessed by an 8-item Morisky Medication Adherence Scale (MMAS-8). Multiple logistic regression analysis was used to identify the factors associated with medication compliance.
There was a significant difference in OSDI (P = 0.043), Schirmer's test (P < 0.001), TBUT (P < 0.001), KEP score (P = 0.015) and all meibomian gland parameters (all P < 0.001) between two groups. When the NTG group was divided into compliant and non-compliant groups based on the scores of MMAS-8, 30 (75%) patients were classified into the compliant group. Multiple logistic regression analysis revealed that the lid margin score (OR, 0.256; 95% CI, 0.072-0.908, P = 0.035), meibum score (OR, 0.144; 95% CI, 0.023-0.915, P = 0.04), and meibo score (OR, 0.344; 95% CI, 0.140-0.845, P = 0.02) were significant factors associated with compliance in patients with NTG. The meibomian gland parameters showed a negative correlation with medication compliance (all P < 0.005).
Malfunction of the meibomian glands can be an important clinical finding associated with compliance of PGA monotherapy in patients with NTG. |
| doi_str_mv | 10.1371/journal.pone.0191398 |
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Ocular surface disease index (OSDI), Schirmer's test, tear film break-up time (TBUT), keratoepitheliopathy (KEP) score with fluorescein, and meibomian gland parameters were assessed in 45 eyes of 45 patients with NTG (NTG group), who received topical PGA monotherapy for more than 1 year. The results were compared to those of 40 eyes of 40 normal subjects (control group). Medication compliance was assessed by an 8-item Morisky Medication Adherence Scale (MMAS-8). Multiple logistic regression analysis was used to identify the factors associated with medication compliance.
There was a significant difference in OSDI (P = 0.043), Schirmer's test (P < 0.001), TBUT (P < 0.001), KEP score (P = 0.015) and all meibomian gland parameters (all P < 0.001) between two groups. When the NTG group was divided into compliant and non-compliant groups based on the scores of MMAS-8, 30 (75%) patients were classified into the compliant group. Multiple logistic regression analysis revealed that the lid margin score (OR, 0.256; 95% CI, 0.072-0.908, P = 0.035), meibum score (OR, 0.144; 95% CI, 0.023-0.915, P = 0.04), and meibo score (OR, 0.344; 95% CI, 0.140-0.845, P = 0.02) were significant factors associated with compliance in patients with NTG. The meibomian gland parameters showed a negative correlation with medication compliance (all P < 0.005).
Malfunction of the meibomian glands can be an important clinical finding associated with compliance of PGA monotherapy in patients with NTG.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0191398</identifier><identifier>PMID: 29385185</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analogs ; Analysis ; Biology and Life Sciences ; Care and treatment ; Chloride ; Comparative analysis ; Cornea ; Drugs ; Eye ; Eye (anatomy) ; Fluorescein ; Glands ; Glaucoma ; Health aspects ; Medical schools ; Medicine and Health Sciences ; Patient compliance ; Patients ; Regression analysis ; Synthetic prostaglandins E ; Tearing ; Tension</subject><ispartof>PloS one, 2018-01, Vol.13 (1), p.e0191398-e0191398</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Lee et al 2018 Lee et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-13327b3c940ebf74c92f642d2c08045a2b777ffeb1a69413bce8399718d2edd93</citedby><cites>FETCH-LOGICAL-c692t-13327b3c940ebf74c92f642d2c08045a2b777ffeb1a69413bce8399718d2edd93</cites><orcidid>0000-0002-3470-6146</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791996/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791996/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29385185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Agnifili, Luca</contributor><creatorcontrib>Lee, Tae Hee</creatorcontrib><creatorcontrib>Sung, Mi Sun</creatorcontrib><creatorcontrib>Heo, Hwan</creatorcontrib><creatorcontrib>Park, Sang Woo</creatorcontrib><title>Association between meibomian gland dysfunction and compliance of topical prostaglandin analogs in patients with normal tension glaucoma</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The aim of this study was to investigate the association between tear film and meibomian gland parameters in patients with normal tension glaucoma (NTG), who underwent topical prostaglandin analog (PGA) monotherapy, and medication compliance.
Ocular surface disease index (OSDI), Schirmer's test, tear film break-up time (TBUT), keratoepitheliopathy (KEP) score with fluorescein, and meibomian gland parameters were assessed in 45 eyes of 45 patients with NTG (NTG group), who received topical PGA monotherapy for more than 1 year. The results were compared to those of 40 eyes of 40 normal subjects (control group). Medication compliance was assessed by an 8-item Morisky Medication Adherence Scale (MMAS-8). Multiple logistic regression analysis was used to identify the factors associated with medication compliance.
There was a significant difference in OSDI (P = 0.043), Schirmer's test (P < 0.001), TBUT (P < 0.001), KEP score (P = 0.015) and all meibomian gland parameters (all P < 0.001) between two groups. When the NTG group was divided into compliant and non-compliant groups based on the scores of MMAS-8, 30 (75%) patients were classified into the compliant group. Multiple logistic regression analysis revealed that the lid margin score (OR, 0.256; 95% CI, 0.072-0.908, P = 0.035), meibum score (OR, 0.144; 95% CI, 0.023-0.915, P = 0.04), and meibo score (OR, 0.344; 95% CI, 0.140-0.845, P = 0.02) were significant factors associated with compliance in patients with NTG. The meibomian gland parameters showed a negative correlation with medication compliance (all P < 0.005).
Malfunction of the meibomian glands can be an important clinical finding associated with compliance of PGA monotherapy in patients with NTG.</description><subject>Analogs</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Chloride</subject><subject>Comparative analysis</subject><subject>Cornea</subject><subject>Drugs</subject><subject>Eye</subject><subject>Eye (anatomy)</subject><subject>Fluorescein</subject><subject>Glands</subject><subject>Glaucoma</subject><subject>Health aspects</subject><subject>Medical schools</subject><subject>Medicine and Health Sciences</subject><subject>Patient compliance</subject><subject>Patients</subject><subject>Regression analysis</subject><subject>Synthetic prostaglandins 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between meibomian gland dysfunction and compliance of topical prostaglandin analogs in patients with normal tension glaucoma</title><author>Lee, Tae Hee ; Sung, Mi Sun ; Heo, Hwan ; Park, Sang Woo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-13327b3c940ebf74c92f642d2c08045a2b777ffeb1a69413bce8399718d2edd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analogs</topic><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Care and treatment</topic><topic>Chloride</topic><topic>Comparative analysis</topic><topic>Cornea</topic><topic>Drugs</topic><topic>Eye</topic><topic>Eye (anatomy)</topic><topic>Fluorescein</topic><topic>Glands</topic><topic>Glaucoma</topic><topic>Health aspects</topic><topic>Medical schools</topic><topic>Medicine and Health Sciences</topic><topic>Patient compliance</topic><topic>Patients</topic><topic>Regression analysis</topic><topic>Synthetic prostaglandins E</topic><topic>Tearing</topic><topic>Tension</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Tae Hee</creatorcontrib><creatorcontrib>Sung, Mi Sun</creatorcontrib><creatorcontrib>Heo, Hwan</creatorcontrib><creatorcontrib>Park, Sang Woo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical 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Sun</au><au>Heo, Hwan</au><au>Park, Sang Woo</au><au>Agnifili, Luca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between meibomian gland dysfunction and compliance of topical prostaglandin analogs in patients with normal tension glaucoma</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-01-31</date><risdate>2018</risdate><volume>13</volume><issue>1</issue><spage>e0191398</spage><epage>e0191398</epage><pages>e0191398-e0191398</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The aim of this study was to investigate the association between tear film and meibomian gland parameters in patients with normal tension glaucoma (NTG), who underwent topical prostaglandin analog (PGA) monotherapy, and medication compliance.
Ocular surface disease index (OSDI), Schirmer's test, tear film break-up time (TBUT), keratoepitheliopathy (KEP) score with fluorescein, and meibomian gland parameters were assessed in 45 eyes of 45 patients with NTG (NTG group), who received topical PGA monotherapy for more than 1 year. The results were compared to those of 40 eyes of 40 normal subjects (control group). Medication compliance was assessed by an 8-item Morisky Medication Adherence Scale (MMAS-8). Multiple logistic regression analysis was used to identify the factors associated with medication compliance.
There was a significant difference in OSDI (P = 0.043), Schirmer's test (P < 0.001), TBUT (P < 0.001), KEP score (P = 0.015) and all meibomian gland parameters (all P < 0.001) between two groups. When the NTG group was divided into compliant and non-compliant groups based on the scores of MMAS-8, 30 (75%) patients were classified into the compliant group. Multiple logistic regression analysis revealed that the lid margin score (OR, 0.256; 95% CI, 0.072-0.908, P = 0.035), meibum score (OR, 0.144; 95% CI, 0.023-0.915, P = 0.04), and meibo score (OR, 0.344; 95% CI, 0.140-0.845, P = 0.02) were significant factors associated with compliance in patients with NTG. The meibomian gland parameters showed a negative correlation with medication compliance (all P < 0.005).
Malfunction of the meibomian glands can be an important clinical finding associated with compliance of PGA monotherapy in patients with NTG.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29385185</pmid><doi>10.1371/journal.pone.0191398</doi><tpages>e0191398</tpages><orcidid>https://orcid.org/0000-0002-3470-6146</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analogs Analysis Biology and Life Sciences Care and treatment Chloride Comparative analysis Cornea Drugs Eye Eye (anatomy) Fluorescein Glands Glaucoma Health aspects Medical schools Medicine and Health Sciences Patient compliance Patients Regression analysis Synthetic prostaglandins E Tearing Tension |
| title | Association between meibomian gland dysfunction and compliance of topical prostaglandin analogs in patients with normal tension glaucoma |
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