Association of circulating CTRP9 with soluble adhesion molecules and inflammatory markers in patients with type 2 diabetes mellitus and coronary artery disease
C1q/TNF-related protein 9 (CTRP9) is a paralogue of adiponectin with known favorable effects on lipid and glucose metabolism. A potential role of CTRP9 for regulation of endothelium function has been suggested by previous studies. However, no studies have examined the relation between serum CTRP9 le...
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| description | C1q/TNF-related protein 9 (CTRP9) is a paralogue of adiponectin with known favorable effects on lipid and glucose metabolism. A potential role of CTRP9 for regulation of endothelium function has been suggested by previous studies. However, no studies have examined the relation between serum CTRP9 levels and adhesion molecules in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). The present study was conducted on 337 subjects who underwent coronary angiography and were categorized into four groups according to the presence of CAD and T2DM (control, CAD, T2DM and CAD+T2DM). Serum levels of CTRP9, adiponectin, sICAM-1, sVCAM-1, sE-Selectin, IL-6 and TNF-α were measured. It was found that the circulating CTRP9 levels were independently associated with increased risk of CAD and T2DM in addition to elevated levels of serum CTRP9 in CAD, T2DM and CAD+T2DM groups. A significant association of serum CTRP9 levels with adhesion molecules in CAD and T2DM patients as well as serum TNF-α levels in CAD individuals was noted. A significant relation between the circulating levels of CTRP9 and HOMA-IR in T2DM subjects was also observed. The results revealed increased circulating levels of CTRP9 in T2DM and CAD individuals which suggests a compensatory response to insulin resistance, inflammatory milieu and endothelial dysfunction; however, more studies are needed to confirm this. |
| doi_str_mv | 10.1371/journal.pone.0192159 |
| format | Article |
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A potential role of CTRP9 for regulation of endothelium function has been suggested by previous studies. However, no studies have examined the relation between serum CTRP9 levels and adhesion molecules in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). The present study was conducted on 337 subjects who underwent coronary angiography and were categorized into four groups according to the presence of CAD and T2DM (control, CAD, T2DM and CAD+T2DM). Serum levels of CTRP9, adiponectin, sICAM-1, sVCAM-1, sE-Selectin, IL-6 and TNF-α were measured. It was found that the circulating CTRP9 levels were independently associated with increased risk of CAD and T2DM in addition to elevated levels of serum CTRP9 in CAD, T2DM and CAD+T2DM groups. A significant association of serum CTRP9 levels with adhesion molecules in CAD and T2DM patients as well as serum TNF-α levels in CAD individuals was noted. A significant relation between the circulating levels of CTRP9 and HOMA-IR in T2DM subjects was also observed. The results revealed increased circulating levels of CTRP9 in T2DM and CAD individuals which suggests a compensatory response to insulin resistance, inflammatory milieu and endothelial dysfunction; however, more studies are needed to confirm this.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0192159</identifier><identifier>PMID: 29381773</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adhesion ; Adiponectin ; Adipose tissue ; Analysis ; Angiography ; Atherosclerosis ; Biochemistry ; Bioindicators ; Biology and Life Sciences ; Body mass index ; Cardiovascular disease ; Cholesterol ; Coronary artery ; Coronary artery disease ; Coronary heart disease ; Coronary vessels ; Cytokines ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Endothelium ; Glucose metabolism ; Heart diseases ; Inflammation ; Insulin ; Insulin resistance ; Interleukin 6 ; Kinases ; Lipid metabolism ; Medicine ; Medicine and Health Sciences ; Metabolism ; Nutrition ; Patients ; Physiological aspects ; Proteins ; Risk factors ; Serum levels ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Type 2 diabetes ; Weight control</subject><ispartof>PloS one, 2018-01, Vol.13 (1), p.e0192159-e0192159</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Moradi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Moradi et al 2018 Moradi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-c19748751465ee3b850b5ab3bf284cb6e23cfb6e4d5c588d721c7d909663a49c3</citedby><cites>FETCH-LOGICAL-c692t-c19748751465ee3b850b5ab3bf284cb6e23cfb6e4d5c588d721c7d909663a49c3</cites><orcidid>0000-0002-7377-6577</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790264/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790264/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29381773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Peterson, Jonathan M.</contributor><creatorcontrib>Moradi, Nariman</creatorcontrib><creatorcontrib>Fadaei, Reza</creatorcontrib><creatorcontrib>Emamgholipour, Solaleh</creatorcontrib><creatorcontrib>Kazemian, Elham</creatorcontrib><creatorcontrib>Panahi, Ghodratollah</creatorcontrib><creatorcontrib>Vahedi, Siamak</creatorcontrib><creatorcontrib>Saed, Lotfolah</creatorcontrib><creatorcontrib>Fallah, Soudabeh</creatorcontrib><title>Association of circulating CTRP9 with soluble adhesion molecules and inflammatory markers in patients with type 2 diabetes mellitus and coronary artery disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>C1q/TNF-related protein 9 (CTRP9) is a paralogue of adiponectin with known favorable effects on lipid and glucose metabolism. A potential role of CTRP9 for regulation of endothelium function has been suggested by previous studies. However, no studies have examined the relation between serum CTRP9 levels and adhesion molecules in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). The present study was conducted on 337 subjects who underwent coronary angiography and were categorized into four groups according to the presence of CAD and T2DM (control, CAD, T2DM and CAD+T2DM). Serum levels of CTRP9, adiponectin, sICAM-1, sVCAM-1, sE-Selectin, IL-6 and TNF-α were measured. It was found that the circulating CTRP9 levels were independently associated with increased risk of CAD and T2DM in addition to elevated levels of serum CTRP9 in CAD, T2DM and CAD+T2DM groups. A significant association of serum CTRP9 levels with adhesion molecules in CAD and T2DM patients as well as serum TNF-α levels in CAD individuals was noted. A significant relation between the circulating levels of CTRP9 and HOMA-IR in T2DM subjects was also observed. The results revealed increased circulating levels of CTRP9 in T2DM and CAD individuals which suggests a compensatory response to insulin resistance, inflammatory milieu and endothelial dysfunction; however, more studies are needed to confirm this.</description><subject>Adhesion</subject><subject>Adiponectin</subject><subject>Adipose tissue</subject><subject>Analysis</subject><subject>Angiography</subject><subject>Atherosclerosis</subject><subject>Biochemistry</subject><subject>Bioindicators</subject><subject>Biology and Life Sciences</subject><subject>Body mass index</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin 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of circulating CTRP9 with soluble adhesion molecules and inflammatory markers in patients with type 2 diabetes mellitus and coronary artery disease</title><author>Moradi, Nariman ; Fadaei, Reza ; Emamgholipour, Solaleh ; Kazemian, Elham ; Panahi, Ghodratollah ; Vahedi, Siamak ; Saed, Lotfolah ; Fallah, Soudabeh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-c19748751465ee3b850b5ab3bf284cb6e23cfb6e4d5c588d721c7d909663a49c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adhesion</topic><topic>Adiponectin</topic><topic>Adipose tissue</topic><topic>Analysis</topic><topic>Angiography</topic><topic>Atherosclerosis</topic><topic>Biochemistry</topic><topic>Bioindicators</topic><topic>Biology and Life Sciences</topic><topic>Body mass index</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Coronary artery</topic><topic>Coronary artery 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Elham</au><au>Panahi, Ghodratollah</au><au>Vahedi, Siamak</au><au>Saed, Lotfolah</au><au>Fallah, Soudabeh</au><au>Peterson, Jonathan M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of circulating CTRP9 with soluble adhesion molecules and inflammatory markers in patients with type 2 diabetes mellitus and coronary artery disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-01-30</date><risdate>2018</risdate><volume>13</volume><issue>1</issue><spage>e0192159</spage><epage>e0192159</epage><pages>e0192159-e0192159</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>C1q/TNF-related protein 9 (CTRP9) is a paralogue of adiponectin with known favorable effects on lipid and glucose metabolism. A potential role of CTRP9 for regulation of endothelium function has been suggested by previous studies. However, no studies have examined the relation between serum CTRP9 levels and adhesion molecules in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). The present study was conducted on 337 subjects who underwent coronary angiography and were categorized into four groups according to the presence of CAD and T2DM (control, CAD, T2DM and CAD+T2DM). Serum levels of CTRP9, adiponectin, sICAM-1, sVCAM-1, sE-Selectin, IL-6 and TNF-α were measured. It was found that the circulating CTRP9 levels were independently associated with increased risk of CAD and T2DM in addition to elevated levels of serum CTRP9 in CAD, T2DM and CAD+T2DM groups. A significant association of serum CTRP9 levels with adhesion molecules in CAD and T2DM patients as well as serum TNF-α levels in CAD individuals was noted. A significant relation between the circulating levels of CTRP9 and HOMA-IR in T2DM subjects was also observed. The results revealed increased circulating levels of CTRP9 in T2DM and CAD individuals which suggests a compensatory response to insulin resistance, inflammatory milieu and endothelial dysfunction; however, more studies are needed to confirm this.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29381773</pmid><doi>10.1371/journal.pone.0192159</doi><tpages>e0192159</tpages><orcidid>https://orcid.org/0000-0002-7377-6577</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adhesion Adiponectin Adipose tissue Analysis Angiography Atherosclerosis Biochemistry Bioindicators Biology and Life Sciences Body mass index Cardiovascular disease Cholesterol Coronary artery Coronary artery disease Coronary heart disease Coronary vessels Cytokines Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Endothelium Glucose metabolism Heart diseases Inflammation Insulin Insulin resistance Interleukin 6 Kinases Lipid metabolism Medicine Medicine and Health Sciences Metabolism Nutrition Patients Physiological aspects Proteins Risk factors Serum levels Tumor necrosis factor-TNF Tumor necrosis factor-α Type 2 diabetes Weight control |
| title | Association of circulating CTRP9 with soluble adhesion molecules and inflammatory markers in patients with type 2 diabetes mellitus and coronary artery disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T13%3A01%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20circulating%20CTRP9%20with%20soluble%20adhesion%20molecules%20and%20inflammatory%20markers%20in%20patients%20with%20type%202%20diabetes%20mellitus%20and%20coronary%20artery%20disease&rft.jtitle=PloS%20one&rft.au=Moradi,%20Nariman&rft.date=2018-01-30&rft.volume=13&rft.issue=1&rft.spage=e0192159&rft.epage=e0192159&rft.pages=e0192159-e0192159&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0192159&rft_dat=%3Cgale_plos_%3EA525648516%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1992660384&rft_id=info:pmid/29381773&rft_galeid=A525648516&rft_doaj_id=oai_doaj_org_article_cb65f4394b044ad089cc3565428ff4cb&rfr_iscdi=true |