Cysteamine-mediated clearance of antibiotic-resistant pathogens in human cystic fibrosis macrophages

Members of the Burkholderia cepacia complex are virulent, multi-drug resistant pathogens that survive and replicate intracellularly in patients with cystic fibrosis (CF). We have discovered that B. cenocepacia cannot be cleared from CF macrophages due to defective autophagy, causing continued system...

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Veröffentlicht in:	PloS one 2017-10, Vol.12 (10), p.e0186169-e0186169
Hauptverfasser:	Shrestha, Chandra L, Assani, Kaivon D, Rinehardt, Hannah, Albastroiu, Florentina, Zhang, Shuzhong, Shell, Richard, Amer, Amal O, Schlesinger, Larry S, Kopp, Benjamin T
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Alveoli Antibiotic resistance Antibiotics Antiinfectives and antibacterials Apoptosis Autophagy Bacteria Bacteria - drug effects Bacteria - growth & development Bacterial infections Biofilms Biology and Life Sciences Blotting, Western Burkholderia cenocepacia Burkholderia cepacia Case-Control Studies Cell death Cell Line Clinical isolates Consent Cysteamine Cysteamine - pharmacology Cystic fibrosis Cystic Fibrosis - microbiology Dosage and administration Drug resistance Drug Resistance, Microbial Drug therapy Enzyme-Linked Immunosorbent Assay Humans IL-1β Inflammation Lymphocytes B Macrophages Macrophages - microbiology Medicine and Health Sciences Microbial drug resistance Microscopy, Confocal Microscopy, Electron, Transmission Monocytes Multidrug resistance Oxygen Pathogenesis Pathogens Pediatrics Peripheral blood Phagocytosis Phagosomes Proteins Reactive oxygen species Staphylococcus aureus Staphylococcus infections Transglutaminase 2
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