Development and validation of novel biomarker assays for osteoarthritis

Osteoarthritis (OA) is the most common chronic joint disease usually diagnosed at relatively advanced stages when there is irreparable damage to the joint(s). Recently, we have identified two novel biomarkers C3f and V65 which appear to be OA-specific and therefore potential markers of early disease...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0181334-e0181334
Hauptverfasser:	Ourradi, Khadija, Xu, Yunhe, de Seny, Dominique, Kirwan, John, Blom, Ashley, Sharif, Mohammed
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibody Formation Arthritis Assaying Biocompatibility Biological markers Biology and Life Sciences Biomarkers Biomarkers - blood Blotting, Western Coefficient of variation Complement C3b - analysis Damage detection Diagnosis Dilution Disease Enzyme-Linked Immunosorbent Assay - methods Genetic aspects Human health sciences Humans Immunoassay Immunoassays Mass spectrometry Medicine and Health Sciences Metabolism Mice Monoclonal antibodies Osteoarthritis Osteoarthritis - blood Osteoarthritis - diagnosis Osteoarthritis - immunology Osteoarthritis/blood/diagnosis/immunology Patients Peptide Fragments - blood Peptides Physiological aspects Polyclonal antibodies Proteins Rabbits Research and Analysis Methods Rheumatology Rhumatologie Sciences de la santé humaine Scientific imaging Sensitivity Sensitivity and Specificity Vitronectin - blood
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