A sequence level model of an intact locus predicts the location and function of nonadditive enhancers

Metazoan gene expression is controlled through the action of long stretches of noncoding DNA that contain enhancers-shorter sequences responsible for controlling a single aspect of a gene's expression pattern. Models built on thermodynamics have shown how enhancers interpret protein concentrati...

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Veröffentlicht in:	PloS one 2017-07, Vol.12 (7), p.e0180861-e0180861
Hauptverfasser:	Barr, Kenneth A, Reinitz, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Biology Biology and Life Sciences Chromatin Chromatin - metabolism Competition Consortia Deoxyribonucleic acid DNA DNA - chemistry DNA - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila Drosophila - genetics Drosophila melanogaster Drosophila Proteins - genetics Drosophila Proteins - metabolism Enhancer Elements, Genetic - genetics Enhancers Gene expression Gene regulation Gene sequencing Genetic aspects Genetic Loci Genetics Genomes Genomics Insects Kinases Loci Mathematical models Metazoans Models, Genetic Noncoding DNA Nucleotide sequence Physiological aspects Proteins Research and Analysis Methods RNA, Messenger - metabolism STAT Transcription Factors - genetics STAT Transcription Factors - metabolism Transcription Transcription (Genetics) Transcription factors Transcription Factors - genetics Transcription Factors - metabolism
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