Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): Inflammation in OPLL
Ossification of the posterior longitudinal ligament (OPLL) is characterized by replacement of ligamentous tissue by ectopic new bone formation. OPLL causes narrowing of the spinal canal, resulting in neurological impairment. However, the pathogenesis of OPLL has not been fully elucidated. We investi...
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| creator | Kawaguchi, Yoshiharu Nakano, Masato Yasuda, Taketoshi Seki, Shoji Suzuki, Kayo Yahara, Yasuhito Makino, Hiroto Kitajima, Isao Kimura, Tomoatsu |
| description | Ossification of the posterior longitudinal ligament (OPLL) is characterized by replacement of ligamentous tissue by ectopic new bone formation. OPLL causes narrowing of the spinal canal, resulting in neurological impairment. However, the pathogenesis of OPLL has not been fully elucidated. We investigated whether inflammation occurs in OPLL or not using high-sensitivity CRP (hs-CRP) in a case-control study.
This study included 103 patients with OPLL in the patient group and 95 age- and sex-matched volunteers with degenerative spinal disease in the control group. Of the 103 OPLL patients, 88 patients who were available for more than 2 years follow-up were checked for OPLL progression. A blood sample was obtained and Hs-CRP, and other routine data, including total protein (TP), albumin (ALB), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), glucose (Glu), calcium (Ca), inorganic phosphate (Pi), white blood cell count (WBC), hemoglobin (Hb) and platelet (PLT), were analyzed. The data were compared between the patients with OPLL and the controls. The severity of the ossified lesions in the whole spine were evaluated by the ossification index (OS index) in patients with OPLL. The data were also compared between the patients with OPLL progression (the progression group) and the patients without OPLL progression (the non-progression group). In the results, the mean hs-CRP in the OPLL group was higher than that in the controls. The Pi in the OPLL group was lower than that in the control group. A negative correlation was found between the Pi and the OS index. The mean hs-CRP in the progression group was higher than that in the non-progression group. There was a positive correlation between the average length of the OPLL progression per year and the hs-CRP.
The results may suggest the occurrence of local inflammation in OPLL and the inflammation might cause OPLL progression. These facts are important for understanding the pathology of OPLL. |
| doi_str_mv | 10.1371/journal.pone.0174881 |
| format | Article |
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This study included 103 patients with OPLL in the patient group and 95 age- and sex-matched volunteers with degenerative spinal disease in the control group. Of the 103 OPLL patients, 88 patients who were available for more than 2 years follow-up were checked for OPLL progression. A blood sample was obtained and Hs-CRP, and other routine data, including total protein (TP), albumin (ALB), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), glucose (Glu), calcium (Ca), inorganic phosphate (Pi), white blood cell count (WBC), hemoglobin (Hb) and platelet (PLT), were analyzed. The data were compared between the patients with OPLL and the controls. The severity of the ossified lesions in the whole spine were evaluated by the ossification index (OS index) in patients with OPLL. The data were also compared between the patients with OPLL progression (the progression group) and the patients without OPLL progression (the non-progression group). In the results, the mean hs-CRP in the OPLL group was higher than that in the controls. The Pi in the OPLL group was lower than that in the control group. A negative correlation was found between the Pi and the OS index. The mean hs-CRP in the progression group was higher than that in the non-progression group. There was a positive correlation between the average length of the OPLL progression per year and the hs-CRP.
The results may suggest the occurrence of local inflammation in OPLL and the inflammation might cause OPLL progression. These facts are important for understanding the pathology of OPLL.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0174881</identifier><identifier>PMID: 28467440</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aged ; Alkaline phosphatase ; Bioindicators ; Biological markers ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Blood ; Bone growth ; Calcium ; Calcium phosphates ; Cardiovascular disease ; Control methods ; Coronary vessels ; Correlation ; Data processing ; Diagnosis ; Disease control ; Disease prevention ; Disease Progression ; Female ; Health aspects ; Heart attacks ; Hemoglobin ; Humans ; Inflammation ; Inflammation - blood ; Inflammation - complications ; Joint surgery ; L-Lactate dehydrogenase ; Lactate dehydrogenase ; Lactic acid ; Lesions ; Leukocytes ; Ligaments ; Male ; Medical examination ; Medicine and Health Sciences ; Middle Aged ; Neurological complications ; Ossification ; Ossification of Posterior Longitudinal Ligament - blood ; Ossification of Posterior Longitudinal Ligament - complications ; Ossification of Posterior Longitudinal Ligament - pathology ; Osteogenesis ; Pathogenesis ; Patients ; Phosphates ; Proteins ; Spine ; Studies ; Surgery ; Systematic review ; Trauma ; White blood cells ; Womens health</subject><ispartof>PloS one, 2017-05, Vol.12 (5), p.e0174881-e0174881</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Kawaguchi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Kawaguchi et al 2017 Kawaguchi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-4db64b4dd4df2defc11c28f1dbda43ba67a51307ab9715c2f1ca3ac442d08a2f3</citedby><cites>FETCH-LOGICAL-c593t-4db64b4dd4df2defc11c28f1dbda43ba67a51307ab9715c2f1ca3ac442d08a2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414934/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414934/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28467440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zhao, Chunfeng</contributor><creatorcontrib>Kawaguchi, Yoshiharu</creatorcontrib><creatorcontrib>Nakano, Masato</creatorcontrib><creatorcontrib>Yasuda, Taketoshi</creatorcontrib><creatorcontrib>Seki, Shoji</creatorcontrib><creatorcontrib>Suzuki, Kayo</creatorcontrib><creatorcontrib>Yahara, Yasuhito</creatorcontrib><creatorcontrib>Makino, Hiroto</creatorcontrib><creatorcontrib>Kitajima, Isao</creatorcontrib><creatorcontrib>Kimura, Tomoatsu</creatorcontrib><title>Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): Inflammation in OPLL</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Ossification of the posterior longitudinal ligament (OPLL) is characterized by replacement of ligamentous tissue by ectopic new bone formation. OPLL causes narrowing of the spinal canal, resulting in neurological impairment. However, the pathogenesis of OPLL has not been fully elucidated. We investigated whether inflammation occurs in OPLL or not using high-sensitivity CRP (hs-CRP) in a case-control study.
This study included 103 patients with OPLL in the patient group and 95 age- and sex-matched volunteers with degenerative spinal disease in the control group. Of the 103 OPLL patients, 88 patients who were available for more than 2 years follow-up were checked for OPLL progression. A blood sample was obtained and Hs-CRP, and other routine data, including total protein (TP), albumin (ALB), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), glucose (Glu), calcium (Ca), inorganic phosphate (Pi), white blood cell count (WBC), hemoglobin (Hb) and platelet (PLT), were analyzed. The data were compared between the patients with OPLL and the controls. The severity of the ossified lesions in the whole spine were evaluated by the ossification index (OS index) in patients with OPLL. The data were also compared between the patients with OPLL progression (the progression group) and the patients without OPLL progression (the non-progression group). In the results, the mean hs-CRP in the OPLL group was higher than that in the controls. The Pi in the OPLL group was lower than that in the control group. A negative correlation was found between the Pi and the OS index. The mean hs-CRP in the progression group was higher than that in the non-progression group. There was a positive correlation between the average length of the OPLL progression per year and the hs-CRP.
The results may suggest the occurrence of local inflammation in OPLL and the inflammation might cause OPLL progression. These facts are important for understanding the pathology of OPLL.</description><subject>Age</subject><subject>Aged</subject><subject>Alkaline phosphatase</subject><subject>Bioindicators</subject><subject>Biological markers</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood</subject><subject>Bone growth</subject><subject>Calcium</subject><subject>Calcium phosphates</subject><subject>Cardiovascular disease</subject><subject>Control methods</subject><subject>Coronary vessels</subject><subject>Correlation</subject><subject>Data processing</subject><subject>Diagnosis</subject><subject>Disease control</subject><subject>Disease prevention</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Health aspects</subject><subject>Heart attacks</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Inflammation - complications</subject><subject>Joint surgery</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactate dehydrogenase</subject><subject>Lactic acid</subject><subject>Lesions</subject><subject>Leukocytes</subject><subject>Ligaments</subject><subject>Male</subject><subject>Medical examination</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Neurological complications</subject><subject>Ossification</subject><subject>Ossification of Posterior Longitudinal Ligament - blood</subject><subject>Ossification of Posterior Longitudinal Ligament - complications</subject><subject>Ossification of Posterior Longitudinal Ligament - pathology</subject><subject>Osteogenesis</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Phosphates</subject><subject>Proteins</subject><subject>Spine</subject><subject>Studies</subject><subject>Surgery</subject><subject>Systematic review</subject><subject>Trauma</subject><subject>White blood cells</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUltrFDEYHUSxtfoPRAO-1Iddc5uZxAehFC8LCxXU5_BNLrtZZybbZMbSf2_GnZaulDwknJxzvgunKF4TvCSsJh92YYw9tMt96O0Sk5oLQZ4Up0QyuqgoZk8fvE-KFyntMC6ZqKrnxQkVvKo5x6dF_GHj2KHGhw7ibxsT8j3aw-BtPyR044ctCil553XGQo-CQ8PWon1Ig40-RNSGfuOH0fjcC2r9BrqsROdX39fr9x_RqnctdN1Bm50n-GXxzEGb7Kv5Pit-ffn88_LbYn31dXV5sV7oUrJhwU1T8YYbw42jxjpNiKbCEdMY4KyBqoaSMFxDI2tSauqIBgaac2qwAOrYWfH24LtvQ1LzupIiUmLOS4nrzFgdGCbATu2jzzu4VQG8-geEuFEQB69bq6qGgdCCCgaON6VutOQ4t-LqylUAk9enudrYdNbovIUI7ZHp8U_vt2oT_qiSEy4Zzwbns0EM16NNg-p80rZtobdhzH0LWdKaSjnVevcf9fHpZtYG8gC-dyHX1ZOpuuCS4ErUosys5SOsfIztvM7Zcj7jRwJ-EOiYkxGtu5-RYDUl864ZNSVTzcnMsjcP93Mvuosi-wsexuL7</recordid><startdate>20170503</startdate><enddate>20170503</enddate><creator>Kawaguchi, Yoshiharu</creator><creator>Nakano, Masato</creator><creator>Yasuda, Taketoshi</creator><creator>Seki, Shoji</creator><creator>Suzuki, Kayo</creator><creator>Yahara, Yasuhito</creator><creator>Makino, Hiroto</creator><creator>Kitajima, Isao</creator><creator>Kimura, Tomoatsu</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170503</creationdate><title>Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): Inflammation in OPLL</title><author>Kawaguchi, Yoshiharu ; Nakano, Masato ; Yasuda, Taketoshi ; Seki, Shoji ; Suzuki, Kayo ; Yahara, Yasuhito ; Makino, Hiroto ; Kitajima, Isao ; Kimura, Tomoatsu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-4db64b4dd4df2defc11c28f1dbda43ba67a51307ab9715c2f1ca3ac442d08a2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Aged</topic><topic>Alkaline phosphatase</topic><topic>Bioindicators</topic><topic>Biological markers</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawaguchi, Yoshiharu</au><au>Nakano, Masato</au><au>Yasuda, Taketoshi</au><au>Seki, Shoji</au><au>Suzuki, Kayo</au><au>Yahara, Yasuhito</au><au>Makino, Hiroto</au><au>Kitajima, Isao</au><au>Kimura, Tomoatsu</au><au>Zhao, Chunfeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): Inflammation in OPLL</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-05-03</date><risdate>2017</risdate><volume>12</volume><issue>5</issue><spage>e0174881</spage><epage>e0174881</epage><pages>e0174881-e0174881</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Ossification of the posterior longitudinal ligament (OPLL) is characterized by replacement of ligamentous tissue by ectopic new bone formation. OPLL causes narrowing of the spinal canal, resulting in neurological impairment. However, the pathogenesis of OPLL has not been fully elucidated. We investigated whether inflammation occurs in OPLL or not using high-sensitivity CRP (hs-CRP) in a case-control study.
This study included 103 patients with OPLL in the patient group and 95 age- and sex-matched volunteers with degenerative spinal disease in the control group. Of the 103 OPLL patients, 88 patients who were available for more than 2 years follow-up were checked for OPLL progression. A blood sample was obtained and Hs-CRP, and other routine data, including total protein (TP), albumin (ALB), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), glucose (Glu), calcium (Ca), inorganic phosphate (Pi), white blood cell count (WBC), hemoglobin (Hb) and platelet (PLT), were analyzed. The data were compared between the patients with OPLL and the controls. The severity of the ossified lesions in the whole spine were evaluated by the ossification index (OS index) in patients with OPLL. The data were also compared between the patients with OPLL progression (the progression group) and the patients without OPLL progression (the non-progression group). In the results, the mean hs-CRP in the OPLL group was higher than that in the controls. The Pi in the OPLL group was lower than that in the control group. A negative correlation was found between the Pi and the OS index. The mean hs-CRP in the progression group was higher than that in the non-progression group. There was a positive correlation between the average length of the OPLL progression per year and the hs-CRP.
The results may suggest the occurrence of local inflammation in OPLL and the inflammation might cause OPLL progression. These facts are important for understanding the pathology of OPLL.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28467440</pmid><doi>10.1371/journal.pone.0174881</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1990445907 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Age Aged Alkaline phosphatase Bioindicators Biological markers Biology and Life Sciences Biomarkers Biomarkers - blood Blood Bone growth Calcium Calcium phosphates Cardiovascular disease Control methods Coronary vessels Correlation Data processing Diagnosis Disease control Disease prevention Disease Progression Female Health aspects Heart attacks Hemoglobin Humans Inflammation Inflammation - blood Inflammation - complications Joint surgery L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Lesions Leukocytes Ligaments Male Medical examination Medicine and Health Sciences Middle Aged Neurological complications Ossification Ossification of Posterior Longitudinal Ligament - blood Ossification of Posterior Longitudinal Ligament - complications Ossification of Posterior Longitudinal Ligament - pathology Osteogenesis Pathogenesis Patients Phosphates Proteins Spine Studies Surgery Systematic review Trauma White blood cells Womens health |
| title | Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): Inflammation in OPLL |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T15%3A18%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20biomarkers%20in%20patients%20with%20ossification%20of%20the%20posterior%20longitudinal%20ligament%20(OPLL):%20Inflammation%20in%20OPLL&rft.jtitle=PloS%20one&rft.au=Kawaguchi,%20Yoshiharu&rft.date=2017-05-03&rft.volume=12&rft.issue=5&rft.spage=e0174881&rft.epage=e0174881&rft.pages=e0174881-e0174881&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0174881&rft_dat=%3Cgale_plos_%3EA491068785%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1990445907&rft_id=info:pmid/28467440&rft_galeid=A491068785&rft_doaj_id=oai_doaj_org_article_6b3a8c8283af4b5cbc940dbdf76f6aa7&rfr_iscdi=true |