Pre-clinical antigenicity studies of an innovative multivalent vaccine for human visceral leishmaniasis

The notion that previous infection by Leishmania spp. in endemic areas leads to robust anti-Leishmania immunity, supports vaccination as a potentially effective approach to prevent disease development. Nevertheless, to date there is no vaccine available for human leishmaniasis. We optimized and asse...

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Veröffentlicht in:	PLoS neglected tropical diseases 2017-11, Vol.11 (11), p.e0005951-e0005951
Hauptverfasser:	Cecílio, Pedro, Pérez-Cabezas, Begoña, Fernández, Laura, Moreno, Javier, Carrillo, Eugenia, Requena, José M, Fichera, Epifanio, Reed, Steven G, Coler, Rhea N, Kamhawi, Shaden, Oliveira, Fabiano, Valenzuela, Jesus G, Gradoni, Luigi, Glueck, Reinhard, Gupta, Gaurav, Cordeiro-da-Silva, Anabela
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Animals Antibodies, Protozoan - blood Antigenicity Antigens Antigens, Protozoan - immunology Biology and Life Sciences CD4 antigen CD8 antigen Cell proliferation Cytokines Deoxyribonucleic acid Development and progression Disease control DNA Funding Health aspects Hematology Humans Immune response Immunity Immunity, Cellular Immunity, Humoral Immunization Immunodominance Immunogenicity Immunogenicity, Vaccine Infections Infectious diseases Influenza Laboratories Leishmania Leishmania donovani Leishmaniasis Vaccines - immunology Leishmaniasis, Visceral - immunology Leishmaniasis, Visceral - prevention & control Lymphocyte Activation Lymphocytes T Malaria Male Medicine and Health Sciences Mice Mice, Inbred BALB C Molecular biology Parasites Parasitic diseases Prevention Priming Proliferation Proteins Psychodidae - immunology Psychodidae - parasitology Recombinant proteins Recombinant Proteins - immunology Recombinants Research and Analysis Methods Safety Saliva Saliva - immunology Sexually transmitted diseases STD TLR4 protein Toll-like receptors Tropical diseases Vaccination Vaccines Vector-borne diseases Virus-like particles Viruses Visceral leishmaniasis
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