Relaxin reverses inflammatory and immune signals in aged hearts

'Healthy' aging drives structural and functional changes in the heart including maladaptive electrical remodeling, fibrosis and inflammation, which lower the threshold for cardiovascular diseases such as heart failure (HF) and atrial fibrillation (AF). Despite mixed results in recent clini...

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Veröffentlicht in:	PloS one 2018-01, Vol.13 (1), p.e0190935-e0190935
Hauptverfasser:	Martin, Brian, Gabris-Weber, Beth Ann, Reddy, Rajiv, Romero, Guillermo, Chattopadhyay, Ansuman, Salama, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Age Age Factors Aging Aging - immunology Animals Apoptosis Atrial Fibrillation - metabolism Atrial natriuretic peptide Bioengineering Biology and Life Sciences Biomarkers - metabolism Cardiovascular disease Cardiovascular diseases Care and treatment Causes of Cell activation Clinical trials Cohort Studies Complement activation Coronary artery disease Coronary vessels Cytokines Diabetes Diabetes mellitus Disease Models, Animal Female Fibrillation Fibrosis Fluorescent Antibody Technique Gene expression Gene sequencing Genes Genetic aspects Health aspects Heart Heart - drug effects Heart diseases Heart Failure - metabolism Humans Immunohistochemistry Infiltration Inflammation Inflammation - drug therapy Inflammatory response Macrophages Macrophages - immunology Male Medical prognosis Medical research Medicine Medicine and Health Sciences Mortality Pathways Physiological aspects Prevention Rats Rats, Inbred F344 Relaxin Relaxin - pharmacology Relaxin - therapeutic use Remodeling Ribonucleic acid Risk factors RNA Rodents Sequence Analysis, RNA Sex Factors Signaling Sodium Sodium acetate Structure-function relationships Studies Therapy Transcription
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