Low expression of IL-18 and IL-18 receptor in human skeletal muscle is associated with systemic and intramuscular lipid metabolism-Role of HIV lipodystrophy

Interleukin (IL)-18 is involved in regulation of lipid and glucose metabolism. Mice lacking whole-body IL-18 signalling are prone to develop weight gain and insulin resistance, a phenotype which is associated with impaired fat oxidation and ectopic skeletal muscle lipid deposition. IL-18 mRNA is exp...

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Veröffentlicht in:	PloS one 2018-01, Vol.13 (1), p.e0186755-e0186755
Hauptverfasser:	Lindegaard, Birgitte, Hvid, Thine, Wolsk Mygind, Helene, Hartvig-Mortensen, Ole, Grøndal, Thomas, Abildgaard, Julie, Gerstoft, Jan, Pedersen, Bente Klarlund, Baranowski, Marcin
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Ceramide Control Correlation Cytokines Diabetes Fatty acids Gene expression Glucose Glucose metabolism High-performance liquid chromatography HIV Human immunodeficiency virus Hypertriglyceridemia Infectious diseases Inflammation Insulin Insulin resistance Interleukin Interleukin 18 Interleukin 18 receptors Kinases Lipid metabolism Lipids Lipodystrophy Liquid chromatography Medicine and Health Sciences Metabolism Mitochondrial DNA Muscles Musculoskeletal system Obesity Oxidation Oxidation resistance Patients Phosphates Physical Sciences Rodents Signaling Skeletal muscle Sphinganine Sphingolipids Sphingosine 1-phosphate Triglycerides Tumor necrosis factor-TNF
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