Contribution of the ankle-brachial index to improve the prediction of coronary risk: The ARTPER cohort
The different cardiovascular risk prediction scales currently available are not sufficiently sensitive. The aim of the present study was to analyze the contribution of the ankle-brachial index (ABI) added to the Framingham and REGICOR risk scales for the reclassification of cardiovascular risk after...
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| Veröffentlicht in: | PloS one 2018-01, Vol.13 (1), p.e0191283-e0191283 |
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| creator | Forés, Rosa Alzamora, Maria Teresa Pera, Guillem Baena-Díez, José Miguel Mundet-Tuduri, Xavier Torán, Pere |
| description | The different cardiovascular risk prediction scales currently available are not sufficiently sensitive.
The aim of the present study was to analyze the contribution of the ankle-brachial index (ABI) added to the Framingham and REGICOR risk scales for the reclassification of cardiovascular risk after a 9-year follow up of a Mediterranean population with low cardiovascular risk.
A population-based prospective cohort study was performed in the province of Barcelona, Spain.
A total of 3,786 subjects >49 years were recruited from 2006-2008. Baseline ABI was performed and cardiovascular risk was calculated with the Framingham and REGICOR scales. The participants were followed until November 2016 by telephone and review of the clinical history every 6 months to confirm the possible appearance of cardiovascular events.
2,716 individuals participated in the study. There were 126 incidental cases of first coronary events (5%) during follow up. The incidence of coronary events in patients with ABI |
| doi_str_mv | 10.1371/journal.pone.0191283 |
| format | Article |
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The aim of the present study was to analyze the contribution of the ankle-brachial index (ABI) added to the Framingham and REGICOR risk scales for the reclassification of cardiovascular risk after a 9-year follow up of a Mediterranean population with low cardiovascular risk.
A population-based prospective cohort study was performed in the province of Barcelona, Spain.
A total of 3,786 subjects >49 years were recruited from 2006-2008. Baseline ABI was performed and cardiovascular risk was calculated with the Framingham and REGICOR scales. The participants were followed until November 2016 by telephone and review of the clinical history every 6 months to confirm the possible appearance of cardiovascular events.
2,716 individuals participated in the study. There were 126 incidental cases of first coronary events (5%) during follow up. The incidence of coronary events in patients with ABI <0.9 was 4-fold greater than that of subjects with a normal ABI (17.2/1,000 persons-year versus 4.8/1,000 persons-year). Improvement in the predictive capacity of REGICOR scale was observed on including ABI in the model, obtaining a net reclassification improvement of 7% (95% confidence interval 0%-13%) for REGICOR+ ABI. Framingham + ABI obtained a NRI of 4% (-2%-11%).
The results of the present study support the addition of the ABI as a tool to help in the reclassification of cardiovascular risk and to confirm the greater incidence of coronary events in patients with ABI < 0.9.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0191283</identifier><identifier>PMID: 29338049</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adaptation ; Aged ; Analysis ; Ankle ; Ankle Brachial Index ; Arteriosclerosis ; Biology and Life Sciences ; Biomarkers ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - physiopathology ; Clinical medicine ; Cohort Studies ; Confidence intervals ; Diabetes ; Disease prevention ; Female ; Follow-Up Studies ; Health risk assessment ; Health risks ; Heart ; Heart attacks ; Humans ; Incidence ; Male ; Medicine and Health Sciences ; Mediterranean culture ; Middle Aged ; Patients ; Population ; Population studies ; Predictions ; Primary care ; Public health ; Reclassification ; Risk ; Risk Factors ; Studies ; Task forces</subject><ispartof>PloS one, 2018-01, Vol.13 (1), p.e0191283-e0191283</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Forés et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Forés et al 2018 Forés et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-e59853b1b84f427608b3aeb9ba12f80721c4bf83064dd4851856760108ec8bd33</citedby><cites>FETCH-LOGICAL-c692t-e59853b1b84f427608b3aeb9ba12f80721c4bf83064dd4851856760108ec8bd33</cites><orcidid>0000-0001-7803-7442</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770061/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770061/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29338049$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Duesbery, N.S.</contributor><creatorcontrib>Forés, Rosa</creatorcontrib><creatorcontrib>Alzamora, Maria Teresa</creatorcontrib><creatorcontrib>Pera, Guillem</creatorcontrib><creatorcontrib>Baena-Díez, José Miguel</creatorcontrib><creatorcontrib>Mundet-Tuduri, Xavier</creatorcontrib><creatorcontrib>Torán, Pere</creatorcontrib><title>Contribution of the ankle-brachial index to improve the prediction of coronary risk: The ARTPER cohort</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The different cardiovascular risk prediction scales currently available are not sufficiently sensitive.
The aim of the present study was to analyze the contribution of the ankle-brachial index (ABI) added to the Framingham and REGICOR risk scales for the reclassification of cardiovascular risk after a 9-year follow up of a Mediterranean population with low cardiovascular risk.
A population-based prospective cohort study was performed in the province of Barcelona, Spain.
A total of 3,786 subjects >49 years were recruited from 2006-2008. Baseline ABI was performed and cardiovascular risk was calculated with the Framingham and REGICOR scales. The participants were followed until November 2016 by telephone and review of the clinical history every 6 months to confirm the possible appearance of cardiovascular events.
2,716 individuals participated in the study. There were 126 incidental cases of first coronary events (5%) during follow up. The incidence of coronary events in patients with ABI <0.9 was 4-fold greater than that of subjects with a normal ABI (17.2/1,000 persons-year versus 4.8/1,000 persons-year). Improvement in the predictive capacity of REGICOR scale was observed on including ABI in the model, obtaining a net reclassification improvement of 7% (95% confidence interval 0%-13%) for REGICOR+ ABI. Framingham + ABI obtained a NRI of 4% (-2%-11%).
The results of the present study support the addition of the ABI as a tool to help in the reclassification of cardiovascular risk and to confirm the greater incidence of coronary events in patients with ABI < 0.9.</description><subject>Adaptation</subject><subject>Aged</subject><subject>Analysis</subject><subject>Ankle</subject><subject>Ankle Brachial Index</subject><subject>Arteriosclerosis</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Clinical medicine</subject><subject>Cohort Studies</subject><subject>Confidence intervals</subject><subject>Diabetes</subject><subject>Disease prevention</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Mediterranean culture</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Population</subject><subject>Population studies</subject><subject>Predictions</subject><subject>Primary care</subject><subject>Public health</subject><subject>Reclassification</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Task 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intervals</topic><topic>Diabetes</topic><topic>Disease prevention</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Mediterranean culture</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Population</topic><topic>Population studies</topic><topic>Predictions</topic><topic>Primary care</topic><topic>Public health</topic><topic>Reclassification</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Task forces</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Forés, Rosa</creatorcontrib><creatorcontrib>Alzamora, Maria Teresa</creatorcontrib><creatorcontrib>Pera, Guillem</creatorcontrib><creatorcontrib>Baena-Díez, José Miguel</creatorcontrib><creatorcontrib>Mundet-Tuduri, 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N.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contribution of the ankle-brachial index to improve the prediction of coronary risk: The ARTPER cohort</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-01-16</date><risdate>2018</risdate><volume>13</volume><issue>1</issue><spage>e0191283</spage><epage>e0191283</epage><pages>e0191283-e0191283</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The different cardiovascular risk prediction scales currently available are not sufficiently sensitive.
The aim of the present study was to analyze the contribution of the ankle-brachial index (ABI) added to the Framingham and REGICOR risk scales for the reclassification of cardiovascular risk after a 9-year follow up of a Mediterranean population with low cardiovascular risk.
A population-based prospective cohort study was performed in the province of Barcelona, Spain.
A total of 3,786 subjects >49 years were recruited from 2006-2008. Baseline ABI was performed and cardiovascular risk was calculated with the Framingham and REGICOR scales. The participants were followed until November 2016 by telephone and review of the clinical history every 6 months to confirm the possible appearance of cardiovascular events.
2,716 individuals participated in the study. There were 126 incidental cases of first coronary events (5%) during follow up. The incidence of coronary events in patients with ABI <0.9 was 4-fold greater than that of subjects with a normal ABI (17.2/1,000 persons-year versus 4.8/1,000 persons-year). Improvement in the predictive capacity of REGICOR scale was observed on including ABI in the model, obtaining a net reclassification improvement of 7% (95% confidence interval 0%-13%) for REGICOR+ ABI. Framingham + ABI obtained a NRI of 4% (-2%-11%).
The results of the present study support the addition of the ABI as a tool to help in the reclassification of cardiovascular risk and to confirm the greater incidence of coronary events in patients with ABI < 0.9.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29338049</pmid><doi>10.1371/journal.pone.0191283</doi><tpages>e0191283</tpages><orcidid>https://orcid.org/0000-0001-7803-7442</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptation Aged Analysis Ankle Ankle Brachial Index Arteriosclerosis Biology and Life Sciences Biomarkers Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - physiopathology Clinical medicine Cohort Studies Confidence intervals Diabetes Disease prevention Female Follow-Up Studies Health risk assessment Health risks Heart Heart attacks Humans Incidence Male Medicine and Health Sciences Mediterranean culture Middle Aged Patients Population Population studies Predictions Primary care Public health Reclassification Risk Risk Factors Studies Task forces |
| title | Contribution of the ankle-brachial index to improve the prediction of coronary risk: The ARTPER cohort |
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