Biofeedback effect of hybrid assistive limb in stroke rehabilitation: A proof of concept study using functional near infrared spectroscopy
Robot-assisted rehabilitation has been increasingly drawing attention in the field of neurorehabilitation. The hybrid assistive limb (HAL) is an exoskeleton robot developed based on the "interactive biofeedback" theory, and several studies have shown its efficacy for patients with stroke....
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| creator | Saita, Kazuya Morishita, Takashi Arima, Hisatomi Hyakutake, Koichi Ogata, Toshiyasu Yagi, Kenji Shiota, Etsuji Inoue, Tooru |
| description | Robot-assisted rehabilitation has been increasingly drawing attention in the field of neurorehabilitation. The hybrid assistive limb (HAL) is an exoskeleton robot developed based on the "interactive biofeedback" theory, and several studies have shown its efficacy for patients with stroke. We aimed to investigate the mechanisms of the facilitative effect of neurorehabilitation using a single-joint HAL (HAL-SJ) and functional near-infrared spectroscopy (fNIRS).
Subacute stroke patients admitted to our hospital were assessed in this study for HAL eligibility. We evaluated motor-related cortical activity using an fNIRS system at baseline and immediately after HAL-SJ treatment on the same day. Cortical activity was determined through the relative changes in the hemoglobin concentrations. For statistical analysis, we compared the number of flexion/extension movements before and immediately after HAL-SJ treatment using paired t-test. fNIRS used both the methods of statistical parametric mapping and random effect analysis.
We finally included 10 patients (eight men, two women; mean age: 66.8 ± 12.0 years). The mean number of flexion/extension movements within 15 s increased significantly from 4.2 ± 3.1 to 5.3 ± 4.1 immediately after training. fNIRS showed increased cortical activation in the primary motor cortex of the ipsilesional hemisphere immediately after HAL-SJ treatment compared to the baseline condition.
This study is the first to support the concept of the biofeedback effect from the perspective of changes in cortical activity measured with an fNIRS system. The biofeedback effect of HAL immediately increased the task-related cortical activity, and this may address the functional recovery. Further studies are warranted to support our findings. |
| doi_str_mv | 10.1371/journal.pone.0191361 |
| format | Article |
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Subacute stroke patients admitted to our hospital were assessed in this study for HAL eligibility. We evaluated motor-related cortical activity using an fNIRS system at baseline and immediately after HAL-SJ treatment on the same day. Cortical activity was determined through the relative changes in the hemoglobin concentrations. For statistical analysis, we compared the number of flexion/extension movements before and immediately after HAL-SJ treatment using paired t-test. fNIRS used both the methods of statistical parametric mapping and random effect analysis.
We finally included 10 patients (eight men, two women; mean age: 66.8 ± 12.0 years). The mean number of flexion/extension movements within 15 s increased significantly from 4.2 ± 3.1 to 5.3 ± 4.1 immediately after training. fNIRS showed increased cortical activation in the primary motor cortex of the ipsilesional hemisphere immediately after HAL-SJ treatment compared to the baseline condition.
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Subacute stroke patients admitted to our hospital were assessed in this study for HAL eligibility. We evaluated motor-related cortical activity using an fNIRS system at baseline and immediately after HAL-SJ treatment on the same day. Cortical activity was determined through the relative changes in the hemoglobin concentrations. For statistical analysis, we compared the number of flexion/extension movements before and immediately after HAL-SJ treatment using paired t-test. fNIRS used both the methods of statistical parametric mapping and random effect analysis.
We finally included 10 patients (eight men, two women; mean age: 66.8 ± 12.0 years). The mean number of flexion/extension movements within 15 s increased significantly from 4.2 ± 3.1 to 5.3 ± 4.1 immediately after training. fNIRS showed increased cortical activation in the primary motor cortex of the ipsilesional hemisphere immediately after HAL-SJ treatment compared to the baseline condition.
This study is the first to support the concept of the biofeedback effect from the perspective of changes in cortical activity measured with an fNIRS system. The biofeedback effect of HAL immediately increased the task-related cortical activity, and this may address the functional recovery. Further studies are warranted to support our findings.</description><subject>Attention</subject><subject>Biofeedback</subject><subject>Biology and Life Sciences</subject><subject>Brain research</subject><subject>Care and treatment</subject><subject>Cortex (motor)</subject><subject>Diagnosis</subject><subject>Electroencephalography</subject><subject>Engineering and Technology</subject><subject>Exoskeleton</subject><subject>Exoskeletons</subject><subject>Feedback</subject><subject>Health care</subject><subject>Hemoglobin</subject><subject>Hospitals</subject><subject>I.R. radiation</subject><subject>Infrared spectra</subject><subject>Infrared spectroscopy</subject><subject>Light emitting diodes</subject><subject>Magnetic resonance imaging</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Near infrared radiation</subject><subject>Near infrared 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effect of hybrid assistive limb in stroke rehabilitation: A proof of concept study using functional near infrared spectroscopy</title><author>Saita, Kazuya ; Morishita, Takashi ; Arima, Hisatomi ; Hyakutake, Koichi ; Ogata, Toshiyasu ; Yagi, Kenji ; Shiota, Etsuji ; Inoue, Tooru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-352fc7d16a4d488e43749c35ca0978c9e0b3ff734cf50a13110965214c2f344c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Attention</topic><topic>Biofeedback</topic><topic>Biology and Life Sciences</topic><topic>Brain research</topic><topic>Care and treatment</topic><topic>Cortex (motor)</topic><topic>Diagnosis</topic><topic>Electroencephalography</topic><topic>Engineering and Technology</topic><topic>Exoskeleton</topic><topic>Exoskeletons</topic><topic>Feedback</topic><topic>Health care</topic><topic>Hemoglobin</topic><topic>Hospitals</topic><topic>I.R. radiation</topic><topic>Infrared spectra</topic><topic>Infrared spectroscopy</topic><topic>Light emitting diodes</topic><topic>Magnetic resonance imaging</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Near infrared radiation</topic><topic>Near infrared spectroscopy</topic><topic>Neurology</topic><topic>Neurosurgery</topic><topic>Patients</topic><topic>Recovery of function</topic><topic>Rehabilitation</topic><topic>Rehabilitation robots</topic><topic>Research and Analysis Methods</topic><topic>Review boards</topic><topic>Robots</topic><topic>Spectroscopy</topic><topic>Spectrum analysis</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Statistics</topic><topic>Stroke</topic><topic>Studies</topic><topic>Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saita, 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Takashi</au><au>Arima, Hisatomi</au><au>Hyakutake, Koichi</au><au>Ogata, Toshiyasu</au><au>Yagi, Kenji</au><au>Shiota, Etsuji</au><au>Inoue, Tooru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biofeedback effect of hybrid assistive limb in stroke rehabilitation: A proof of concept study using functional near infrared spectroscopy</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-01-16</date><risdate>2018</risdate><volume>13</volume><issue>1</issue><spage>e0191361</spage><epage>e0191361</epage><pages>e0191361-e0191361</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Robot-assisted rehabilitation has been increasingly drawing attention in the field of neurorehabilitation. The hybrid assistive limb (HAL) is an exoskeleton robot developed based on the "interactive biofeedback" theory, and several studies have shown its efficacy for patients with stroke. We aimed to investigate the mechanisms of the facilitative effect of neurorehabilitation using a single-joint HAL (HAL-SJ) and functional near-infrared spectroscopy (fNIRS).
Subacute stroke patients admitted to our hospital were assessed in this study for HAL eligibility. We evaluated motor-related cortical activity using an fNIRS system at baseline and immediately after HAL-SJ treatment on the same day. Cortical activity was determined through the relative changes in the hemoglobin concentrations. For statistical analysis, we compared the number of flexion/extension movements before and immediately after HAL-SJ treatment using paired t-test. fNIRS used both the methods of statistical parametric mapping and random effect analysis.
We finally included 10 patients (eight men, two women; mean age: 66.8 ± 12.0 years). The mean number of flexion/extension movements within 15 s increased significantly from 4.2 ± 3.1 to 5.3 ± 4.1 immediately after training. fNIRS showed increased cortical activation in the primary motor cortex of the ipsilesional hemisphere immediately after HAL-SJ treatment compared to the baseline condition.
This study is the first to support the concept of the biofeedback effect from the perspective of changes in cortical activity measured with an fNIRS system. The biofeedback effect of HAL immediately increased the task-related cortical activity, and this may address the functional recovery. Further studies are warranted to support our findings.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29338060</pmid><doi>10.1371/journal.pone.0191361</doi><tpages>e0191361</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| subjects | Attention Biofeedback Biology and Life Sciences Brain research Care and treatment Cortex (motor) Diagnosis Electroencephalography Engineering and Technology Exoskeleton Exoskeletons Feedback Health care Hemoglobin Hospitals I.R. radiation Infrared spectra Infrared spectroscopy Light emitting diodes Magnetic resonance imaging Medical imaging Medicine Medicine and Health Sciences Near infrared radiation Near infrared spectroscopy Neurology Neurosurgery Patients Recovery of function Rehabilitation Rehabilitation robots Research and Analysis Methods Review boards Robots Spectroscopy Spectrum analysis Statistical analysis Statistical methods Statistics Stroke Studies Therapy |
| title | Biofeedback effect of hybrid assistive limb in stroke rehabilitation: A proof of concept study using functional near infrared spectroscopy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T00%3A27%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biofeedback%20effect%20of%20hybrid%20assistive%20limb%20in%20stroke%20rehabilitation:%20A%20proof%20of%20concept%20study%20using%20functional%20near%20infrared%20spectroscopy&rft.jtitle=PloS%20one&rft.au=Saita,%20Kazuya&rft.date=2018-01-16&rft.volume=13&rft.issue=1&rft.spage=e0191361&rft.epage=e0191361&rft.pages=e0191361-e0191361&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0191361&rft_dat=%3Cgale_plos_%3EA523354039%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1988111700&rft_id=info:pmid/29338060&rft_galeid=A523354039&rft_doaj_id=oai_doaj_org_article_35a711b8bdb2405da0430ab94e1cb813&rfr_iscdi=true |