Voltage-dependent calcium channel signaling mediates GABAA receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii

The obligate intracellular parasite Toxoplasma gondii exploits cells of the immune system to disseminate. Upon T. gondii-infection, γ-aminobutyric acid (GABA)/GABAA receptor signaling triggers a hypermigratory phenotype in dendritic cells (DCs) by unknown signal transduction pathways. Here, we demon...

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Veröffentlicht in:	PLoS pathogens 2017-12, Vol.13 (12), p.e1006739-e1006739
Hauptverfasser:	Kanatani, Sachie, Fuks, Jonas M, Olafsson, Einar B, Westermark, Linda, Chambers, Benedict, Varas-Godoy, Manuel, Uhlén, Per, Barragan, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biology and Life Sciences Biophysics Blood circulation Bone marrow Calcium Calcium channels Calcium channels (L-type) Calcium channels (voltage-gated) Calcium influx Calcium signalling Cell activation Cell migration Dendritic cells Electric potential Funding Genotype & phenotype Immune system Infections Interneurons Laboratories Medicine Medicine and Health Sciences Motility Nervous system Neurobiology Neurosciences Organs Parasites Pharmacology Protozoa Receptors Ribonucleic acid RNA Rodents Signal transduction Toxoplasma gondii Toxoplasmosis γ-Aminobutyric acid A receptors
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