Investigation of Motor Cortical Plasticity and Corticospinal Tract Diffusion Tensor Imaging in Patients with Parkinsons Disease and Essential Tremor
Parkinson's disease (PD) and essential tremor (ET) are characterized with motor dysfunctions. Motor circuit dysfunctions can be complementarily investigated by paired associative stimulation (PAS)-induced long-term potentiation (LTP)-like plasticity and diffusion tensor imaging (DTI) of the cor...
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| description | Parkinson's disease (PD) and essential tremor (ET) are characterized with motor dysfunctions. Motor circuit dysfunctions can be complementarily investigated by paired associative stimulation (PAS)-induced long-term potentiation (LTP)-like plasticity and diffusion tensor imaging (DTI) of the corticospinal tract (CST). Three groups of twelve subjects with moderate severity PD, ET with intention tremor and healthy controls (HC) were studied. The primary motor cortex (M1) excitability, measured by motor evoked potential (MEP) amplitude and by short-interval and long-interval intracortical inhibition (SICI and LICI) was compared between the three groups before and after PAS. The DTI measures of fractional anisotropy (FA) and mean diffusivity (MD) were acquired. PAS effects and DTI data were simultaneously examined between groups. PAS increased MEP amplitude in HC but not in PD and ET. SICI and LICI were significantly reduced after PAS irrespective of groups. No significant differences of the mean FA and MD were found between groups. There was no significant correlation between the PAS effects and the DTI measures. Findings suggest that both PD and ET with intention tremor have impairment of the associative LTP-like corticospinal excitability change in M1. The microstructure of the CST is not relevant to the deficiency of M1 associative plasticity in PD and ET. |
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Motor circuit dysfunctions can be complementarily investigated by paired associative stimulation (PAS)-induced long-term potentiation (LTP)-like plasticity and diffusion tensor imaging (DTI) of the corticospinal tract (CST). Three groups of twelve subjects with moderate severity PD, ET with intention tremor and healthy controls (HC) were studied. The primary motor cortex (M1) excitability, measured by motor evoked potential (MEP) amplitude and by short-interval and long-interval intracortical inhibition (SICI and LICI) was compared between the three groups before and after PAS. The DTI measures of fractional anisotropy (FA) and mean diffusivity (MD) were acquired. PAS effects and DTI data were simultaneously examined between groups. PAS increased MEP amplitude in HC but not in PD and ET. SICI and LICI were significantly reduced after PAS irrespective of groups. No significant differences of the mean FA and MD were found between groups. There was no significant correlation between the PAS effects and the DTI measures. Findings suggest that both PD and ET with intention tremor have impairment of the associative LTP-like corticospinal excitability change in M1. The microstructure of the CST is not relevant to the deficiency of M1 associative plasticity in PD and ET.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0162265</identifier><identifier>PMID: 27603204</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aged ; Analysis of Variance ; Anisotropy ; Biology and Life Sciences ; Care and treatment ; Comparative analysis ; Cortex (motor) ; Demography ; Diagnostic imaging ; Diffusion ; Diffusion Tensor Imaging - methods ; Essential Tremor - complications ; Essential Tremor - physiopathology ; Evoked Potentials, Motor - physiology ; Evoked Potentials, Somatosensory - physiology ; Excitability ; Female ; Hospitals ; Humans ; Laboratories ; Long-term potentiation ; Magnetic resonance imaging ; Male ; Median Nerve - physiopathology ; Medical imaging ; Medicine ; Medicine and Health Sciences ; Motivation ; Motor Cortex - physiopathology ; Motor evoked potentials ; Movement disorders ; Neural plasticity ; Neurodegenerative diseases ; Neuroimaging ; Neurological disorders ; Neurology ; Neuronal Plasticity - physiology ; Neuroplasticity ; Neurosciences ; Paired-Associate Learning ; Parkinson Disease - physiopathology ; Parkinson's disease ; Physical Sciences ; Plastic properties ; Plasticity ; Pyramidal tracts ; Pyramidal Tracts - physiopathology ; Research and Analysis Methods ; Sensory Thresholds - physiology ; Studies ; Transcranial Magnetic Stimulation ; Tremor</subject><ispartof>PloS one, 2016-09, Vol.11 (9), p.e0162265-e0162265</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Lu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Lu et al 2016 Lu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4fe637ca501bdea9d5ed0abf89bbc617f508c2de438018cf2211ee425db50cab3</citedby><cites>FETCH-LOGICAL-c692t-4fe637ca501bdea9d5ed0abf89bbc617f508c2de438018cf2211ee425db50cab3</cites><orcidid>0000-0002-2768-4399</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014415/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014415/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27603204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Antal, Andrea</contributor><creatorcontrib>Lu, Ming-Kuei</creatorcontrib><creatorcontrib>Chen, Chun-Ming</creatorcontrib><creatorcontrib>Duann, Jeng-Ren</creatorcontrib><creatorcontrib>Ziemann, Ulf</creatorcontrib><creatorcontrib>Chen, Jui-Cheng</creatorcontrib><creatorcontrib>Chiou, Shang-Ming</creatorcontrib><creatorcontrib>Tsai, Chon-Haw</creatorcontrib><title>Investigation of Motor Cortical Plasticity and Corticospinal Tract Diffusion Tensor Imaging in Patients with Parkinsons Disease and Essential Tremor</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Parkinson's disease (PD) and essential tremor (ET) are characterized with motor dysfunctions. Motor circuit dysfunctions can be complementarily investigated by paired associative stimulation (PAS)-induced long-term potentiation (LTP)-like plasticity and diffusion tensor imaging (DTI) of the corticospinal tract (CST). Three groups of twelve subjects with moderate severity PD, ET with intention tremor and healthy controls (HC) were studied. The primary motor cortex (M1) excitability, measured by motor evoked potential (MEP) amplitude and by short-interval and long-interval intracortical inhibition (SICI and LICI) was compared between the three groups before and after PAS. The DTI measures of fractional anisotropy (FA) and mean diffusivity (MD) were acquired. PAS effects and DTI data were simultaneously examined between groups. PAS increased MEP amplitude in HC but not in PD and ET. SICI and LICI were significantly reduced after PAS irrespective of groups. No significant differences of the mean FA and MD were found between groups. There was no significant correlation between the PAS effects and the DTI measures. Findings suggest that both PD and ET with intention tremor have impairment of the associative LTP-like corticospinal excitability change in M1. The microstructure of the CST is not relevant to the deficiency of M1 associative plasticity in PD and ET.</description><subject>Age</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Anisotropy</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Comparative analysis</subject><subject>Cortex (motor)</subject><subject>Demography</subject><subject>Diagnostic imaging</subject><subject>Diffusion</subject><subject>Diffusion Tensor Imaging - methods</subject><subject>Essential Tremor - complications</subject><subject>Essential Tremor - physiopathology</subject><subject>Evoked Potentials, Motor - physiology</subject><subject>Evoked Potentials, Somatosensory - physiology</subject><subject>Excitability</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Long-term potentiation</subject><subject>Magnetic resonance 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Tensor Imaging in Patients with Parkinsons Disease and Essential Tremor</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-09-07</date><risdate>2016</risdate><volume>11</volume><issue>9</issue><spage>e0162265</spage><epage>e0162265</epage><pages>e0162265-e0162265</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Parkinson's disease (PD) and essential tremor (ET) are characterized with motor dysfunctions. Motor circuit dysfunctions can be complementarily investigated by paired associative stimulation (PAS)-induced long-term potentiation (LTP)-like plasticity and diffusion tensor imaging (DTI) of the corticospinal tract (CST). Three groups of twelve subjects with moderate severity PD, ET with intention tremor and healthy controls (HC) were studied. The primary motor cortex (M1) excitability, measured by motor evoked potential (MEP) amplitude and by short-interval and long-interval intracortical inhibition (SICI and LICI) was compared between the three groups before and after PAS. The DTI measures of fractional anisotropy (FA) and mean diffusivity (MD) were acquired. PAS effects and DTI data were simultaneously examined between groups. PAS increased MEP amplitude in HC but not in PD and ET. SICI and LICI were significantly reduced after PAS irrespective of groups. No significant differences of the mean FA and MD were found between groups. There was no significant correlation between the PAS effects and the DTI measures. Findings suggest that both PD and ET with intention tremor have impairment of the associative LTP-like corticospinal excitability change in M1. The microstructure of the CST is not relevant to the deficiency of M1 associative plasticity in PD and ET.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27603204</pmid><doi>10.1371/journal.pone.0162265</doi><tpages>e0162265</tpages><orcidid>https://orcid.org/0000-0002-2768-4399</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-09, Vol.11 (9), p.e0162265-e0162265 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1987647171 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Aged Analysis of Variance Anisotropy Biology and Life Sciences Care and treatment Comparative analysis Cortex (motor) Demography Diagnostic imaging Diffusion Diffusion Tensor Imaging - methods Essential Tremor - complications Essential Tremor - physiopathology Evoked Potentials, Motor - physiology Evoked Potentials, Somatosensory - physiology Excitability Female Hospitals Humans Laboratories Long-term potentiation Magnetic resonance imaging Male Median Nerve - physiopathology Medical imaging Medicine Medicine and Health Sciences Motivation Motor Cortex - physiopathology Motor evoked potentials Movement disorders Neural plasticity Neurodegenerative diseases Neuroimaging Neurological disorders Neurology Neuronal Plasticity - physiology Neuroplasticity Neurosciences Paired-Associate Learning Parkinson Disease - physiopathology Parkinson's disease Physical Sciences Plastic properties Plasticity Pyramidal tracts Pyramidal Tracts - physiopathology Research and Analysis Methods Sensory Thresholds - physiology Studies Transcranial Magnetic Stimulation Tremor |
| title | Investigation of Motor Cortical Plasticity and Corticospinal Tract Diffusion Tensor Imaging in Patients with Parkinsons Disease and Essential Tremor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T16%3A37%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Investigation%20of%20Motor%20Cortical%20Plasticity%20and%20Corticospinal%20Tract%20Diffusion%20Tensor%20Imaging%20in%20Patients%20with%20Parkinsons%20Disease%20and%20Essential%20Tremor&rft.jtitle=PloS%20one&rft.au=Lu,%20Ming-Kuei&rft.date=2016-09-07&rft.volume=11&rft.issue=9&rft.spage=e0162265&rft.epage=e0162265&rft.pages=e0162265-e0162265&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0162265&rft_dat=%3Cgale_plos_%3EA470941733%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1987647171&rft_id=info:pmid/27603204&rft_galeid=A470941733&rft_doaj_id=oai_doaj_org_article_3d15bc77dab946f0aed842822310d4ca&rfr_iscdi=true |