Symmetric dimeric bisbenzimidazoles DBP(n) reduce methylation of RARB and PTEN while significantly increase methylation of rRNA genes in MCF-7 cancer cells

Hypermethylation is observed in the promoter regions of suppressor genes in the tumor cancer cells. Reactivation of these genes by demethylation of their promoters is a prospective strategy of the anticancer therapy. Previous experiments have shown that symmetric dimeric bisbenzimidazoles DBP(n) are...

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Veröffentlicht in:	PloS one 2018-01, Vol.13 (1), p.e0189826
Hauptverfasser:	Kostyuk, Svetlana V, Kvasha, Margarita A, Khrabrova, Daria A, Kirsanova, Olga V, Ershova, Elizaveta S, Malinovskaya, Elena M, Veiko, Natalia N, Ivanov, Alexander A, Koval, Vasiliy S, Zhuze, Alexei L, Tashlitsky, Vadim H, Umriukhin, Pavel E, Kutsev, Sergey I, Gromova, Elizaveta S
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenomatous polyposis coli Anticancer properties Antitumor agents Apaf-1 protein Benzimidazoles Benzimidazoles - chemistry Benzimidazoles - pharmacology Biology and life sciences Breast cancer Breast carcinoma Cancer Cancer cells Cell cycle Cell membranes Demethylation Deoxyribonucleic acid Dimerization Dimers DNA DNA methylation DNA Methylation - drug effects DNA methyltransferase Funding Gene expression Genes Genomes HeLa Cells Humans Immunoglobulins MCF-7 Cells Medical research Methylation Mitochondria Molecular biology Nuclei (cytology) Nucleoli Promoters PTEN Phosphohydrolase PTEN protein Reactive Oxygen Species - metabolism Receptors, Retinoic Acid - genetics Research and Analysis Methods RNA, Ribosomal - genetics rRNA Runx3 protein Sarcoma Software Tumor suppressor genes Tumors
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