Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer

Citrullinated histone H3 (H3Cit) is a central player in the neutrophil release of nuclear chromatin, known as neutrophil extracellular traps (NETs). NETs have been shown to elicit harmful effects on the host, and were recently proposed to promote tumor progression and spread. Here we report signific...

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Veröffentlicht in:	PloS one 2018-01, Vol.13 (1), p.e0191231-e0191231
Hauptverfasser:	Thålin, Charlotte, Lundström, Staffan, Seignez, Cedric, Daleskog, Maud, Lundström, Annika, Henriksson, Peter, Helleday, Thomas, Phillipson, Mia, Wallén, Håkan, Demers, Mélanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Apoptosis Biological markers Biology Biology and Life Sciences Biomarkers, Tumor - blood Biomarkers, Tumor - chemistry Blood Cancer Case-Control Studies Cell activation Chromatin Citrullination Citrulline Cytokines Deoxyribonucleic acid Diagnosis Diagnostic systems Disease DNA Elastase Extracellular Traps - immunology Extracellular Traps - metabolism Female Genetic aspects Health risks Histone H3 Histones Histones - blood Histones - chemistry Hospitals Humans Immune system Immunology Inflammation Inflammatory diseases Inflammatory response Interleukin 6 Interleukin-6 - blood Interleukin-8 - blood Internal medicine Leukocytes (neutrophilic) Male Medical diagnosis Medical prognosis Medicine Medicine and Health Sciences Middle Aged Neoplasms - blood Neoplasms - immunology Neoplasms - mortality Neutrophil Activation Neutrophils Neutrophils - immunology Neutrophils - metabolism Patients Peroxidase Physiological aspects Prognosis Thrombosis Tumors
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