CD45 Isoform Profile Identifies Natural Killer (NK) Subsets with Differential Activity

The leucocyte-specific phosphatase CD45 is present in two main isoforms: the large CD45RA and the short CD45RO. We have recently shown that distinctive expression of these isoforms distinguishes natural killer (NK) populations. For example, co-expression of both isoforms identifies in vivo the anti...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0150434-e0150434
Hauptverfasser:	Krzywinska, Ewelina, Cornillon, Amelie, Allende-Vega, Nerea, Vo, Dang-Nghiem, Rene, Celine, Lu, Zhao-Yang, Pasero, Christine, Olive, Daniel, Fegueux, Nathalie, Ceballos, Patrick, Hicheri, Yosr, Sobecki, Michal, Rossi, Jean-François, Cartron, Guillaume, Villalba, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - immunology Antigens, Differentiation, T-Lymphocyte - immunology Biology and life sciences Biomarkers - metabolism Bone marrow Bone Marrow - immunology Cancer CD45 antigen CD45RA antigen CD69 antigen Cell Line, Tumor Cytokines Cytotoxicity Genetic aspects Hematology Hematopoietic Stem Cell Transplantation - methods Hematopoietic stem cells Humans Isoforms K562 Cells Killer cells Killer Cells, Natural - immunology Kinases Lectins, C-Type - immunology Leukocyte Common Antigens - immunology Life Sciences Lymphocytes Lymphocytes B Lymphocytes T Medicine and health sciences Metabolism Natural killer cells Patients Phosphatases Physiological aspects Protein Isoforms - immunology Research and Analysis Methods Signal transduction T cell receptors Transferrin Transferrins
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