A new genotype imputation method with tolerance to high missing rate and rare variants

We report a novel algorithm, iBLUP, to impute missing genotypes by simultaneously and comprehensively using identity by descent and linkage disequilibrium information. The simulation studies showed that the algorithm exhibited drastically tolerance to high missing rate, especially for rare variants...

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e101025-e101025
Hauptverfasser:	Yang, Yumei, Wang, Qishan, Chen, Qiang, Liao, Rongrong, Zhang, Xiangzhe, Yang, Hongjie, Zheng, Youmin, Zhang, Zhiwu, Pan, Yuchun
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analysis Animals Bioinformatics Biology Biology and Life Sciences Breeding of animals Computer simulation Data processing Gene loci Genetics Genomes Genomics Genotype & phenotype Genotypes Haplotypes Hogs Linkage disequilibrium Methods Polymorphism, Genetic Population Sensitivity and Specificity Software Soil sciences Studies Suidae Swine
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