Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes

TRPV4 channels are calcium-permeable cation channels that are activated by several physicochemical stimuli. Accordingly, TRPV4 channels have been implicated in the regulation of osmosensing, mechanotransduction, thermosensation, and epithelial/endothelial barrier functions. Whether TRPV4 is also mec...

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Veröffentlicht in:	PloS one 2018-01, Vol.13 (1), p.e0190307-e0190307
Hauptverfasser:	Olivan-Viguera, Aida, Garcia-Otin, Angel Luis, Lozano-Gerona, Javier, Abarca-Lachen, Edgar, Garcia-Malinis, Ana J, Hamilton, Kirk L, Gilaberte, Yolanda, Pueyo, Esther, Köhler, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Analysis Apoptosis Biology and Life Sciences Biophysics Biotechnology Breast cancer Calcium Calcium (intracellular) Calcium channels Calcium permeability Calcium-binding protein Calmodulin Cancer Cations Cell activation Cell cycle Cell growth Cell proliferation Channels Densification Dermatology Detachment Edema Engineering research Fibroblasts Flow cytometry Gene expression Genetic aspects Health sciences Ion currents Keratinocytes Leukemia Light microscopy Mechanotransduction Medical prognosis Medicine and Health Sciences Melanoma Metastasis Mutation Pharmacology Physiology R&D Research & development Research and Analysis Methods Rosacea Skin Skin cancer
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