Fluoxetine pretreatment promotes neuronal survival and maturation after auditory fear conditioning in the rat amygdala

The amygdala is a critical brain region for auditory fear conditioning, which is a stressful condition for experimental rats. Adult neurogenesis in the dentate gyrus (DG) of the hippocampus, known to be sensitive to behavioral stress and treatment of the antidepressant fluoxetine (FLX), is involved...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e89147
Hauptverfasser:	Jiang, Lizhu, Liu, Chen, Tong, Jianbin, Mao, Rongrong, Chen, Dan, Wang, Hui, Huang, Jufang, Li, Lingjiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Amygdala Amygdala - cytology Amygdala - drug effects Amygdala - physiology Animals Antidepressive Agents, Second-Generation - pharmacology Astrocytes Astrocytes - cytology Astrocytes - drug effects Astrocytes - physiology Biology Brain Brain-derived neurotrophic factor Bromodeoxyuridine Cell Differentiation - drug effects Cell growth Cell Proliferation - drug effects Cell survival Cell Survival - drug effects Conditioning Conditioning, Classical - drug effects Conditioning, Classical - physiology Dentate gyrus Fear Fear & phobias Fear - drug effects Fear - psychology Fear conditioning Fluoxetine Fluoxetine - pharmacology Gene expression Glial fibrillary acidic protein Hippocampus Hippocampus - cytology Hippocampus - drug effects Hippocampus - physiology Hospitals Kinases Male Maturation Medicine Memory Mental health Neurobiology Neurogenesis Neurogenesis - drug effects Neurogenesis - physiology Neurons Neurons - cytology Neurons - drug effects Neurons - physiology Neurosciences Post traumatic stress disorder Psychiatry Rats Rats, Sprague-Dawley Rodents Survival
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