Digoxin Suppresses Tumor Malignancy through Inhibiting Multiple Src-Related Signaling Pathways in Non-Small Cell Lung Cancer

Non-small cell lung cancer is the predominant type of lung cancer, resulting in high mortality worldwide. Digoxin, a cardiac glycoside, has recently been suggested to be a novel chemotherapeutic agent. Src is an oncogene that plays an important role in cancer progression and is therefore a potential...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0123305-e0123305
Hauptverfasser:	Lin, Sheng-Yi, Chang, Hsiu-Hui, Lai, Yi-Hua, Lin, Ching-Hsiung, Chen, Min-Hsuan, Chang, Gee-Chen, Tsai, Meng-Feng, Chen, Jeremy J W
Format:	Artikel
Sprache:	eng
Schlagworte:	Agricultural biotechnology Anticancer properties Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Assaying Autophagy Cancer Cancer prevention Cancer therapies Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - pathology Cell Death - drug effects Cell Line, Tumor Cell Movement - drug effects Cell proliferation Cell Survival - drug effects Chemotherapy Colonies Cytotoxicity Development and progression Digoxin Digoxin - pharmacology Digoxin - therapeutic use Enzyme Activation - drug effects Epidermal growth factor Epidermal growth factor receptors Focal Adhesion Protein-Tyrosine Kinases - metabolism Gastric cancer Gene expression Gene Expression Regulation, Neoplastic - drug effects Health aspects Humans Hypoxia Internal medicine Kinases Lung cancer Lung diseases Lung Neoplasms - drug therapy Lung Neoplasms - enzymology Lung Neoplasms - pathology Malignancy Medical prognosis Medicine Metastasis Models, Biological mRNA Mutation Neoplasm Invasiveness Non-small cell lung cancer Non-small cell lung carcinoma Phosphorylation - drug effects Proteins Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Signal Transduction - drug effects Signaling Small cell lung cancer Src protein src-Family Kinases - metabolism Stat3 protein STAT3 Transcription Factor - metabolism Stomach cancer Toxicity Tumor cell lines Tumor Stem Cell Assay Tumors Western blotting
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