Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells

Although many chemotherapeutic strategies against cancer have been developed, pancreatic cancer is one of the most aggressive and intractable types of malignancies. Therefore, new strategies and anti-cancer agents are necessary to treat this disease. Metformin is a widely used drug for type-2 diabet...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0125779-e0125779
Hauptverfasser:	Tanaka, Ryoichi, Tomosugi, Mitsuhiro, Horinaka, Mano, Sowa, Yoshihiro, Sakai, Toshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antidiabetics Antineoplastic Agents - toxicity Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Bcl-2-Like Protein 11 BIM protein Cancer Cancer therapies Care and treatment Cell cycle Cell growth Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Complications and side effects Cyclin-Dependent Kinase Inhibitor p27 - metabolism Diabetes Diabetes mellitus Disease prevention Down-regulation Down-Regulation - drug effects Drug dosages Drug Resistance, Neoplasm - drug effects G1 Phase Cell Cycle Checkpoints - drug effects Health aspects Humans In vivo methods and tests Influence Kinases Medicine Membrane Proteins - metabolism Metformin Metformin - toxicity MicroRNA MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - metabolism miRNA Mutation Oligonucleotides, Antisense - metabolism p53 Protein Pancreatic cancer Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Penicillin Proteins Proto-Oncogene Proteins - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Science Sensitivity enhancement Stem cells TNF-Related Apoptosis-Inducing Ligand - toxicity TRAIL protein Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors Up-regulation Up-Regulation - drug effects
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