Low serum cartonectin/CTRP3 concentrations in newly diagnosed type 2 diabetes mellitus: in vivo regulation of cartonectin by glucose
Cartonectin is a novel adipokine of the C1q complement/TNF-related protein (CTRP) superfamily, with glucose lowering effects, anti-inflammatory and cardio-protective properties. We sought to investigate circulating cartonectin concentrations in subjects with type 2 diabetes mellitus (T2DM) as well a...
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| creator | Ban, Bo Bai, Bo Zhang, Manman Hu, Jiamiao Ramanjaneya, Manjunath Tan, Bee K Chen, Jing |
| description | Cartonectin is a novel adipokine of the C1q complement/TNF-related protein (CTRP) superfamily, with glucose lowering effects, anti-inflammatory and cardio-protective properties. We sought to investigate circulating cartonectin concentrations in subjects with type 2 diabetes mellitus (T2DM) as well as age and BMI matched control subjects. We also examined the effects of a 2 hour 75 g oral glucose tolerance test (OGTT) on serum cartonectin concentrations in T2DM subjects.
Cross-sectional study [newly diagnosed (first discovery, not on any treatments) T2DM (n = 47) and control (n = 63) subjects]. Serum cartonectin was measured by ELISA.
Serum cartonectin concentrations were significantly lower in patients with T2DM compared to controls (P0.05). There were no significant correlations in T2DM subjects (n = 47). In control subjects (n = 63), serum cartonectin was significantly negatively correlated with CRP, and significantly positively correlated with insulin, HOMA-IR and leptin. However, when subjected to multiple regression analysis, none of these variables were predictive of serum cartonectin (P>0.05). Finally, serum cartonectin concentrations were significantly lower in T2DM subjects after a 2 hour 75 g OGTT (P |
| doi_str_mv | 10.1371/journal.pone.0112931 |
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Cross-sectional study [newly diagnosed (first discovery, not on any treatments) T2DM (n = 47) and control (n = 63) subjects]. Serum cartonectin was measured by ELISA.
Serum cartonectin concentrations were significantly lower in patients with T2DM compared to controls (P<0.05). Furthermore, serum cartonectin was significantly negatively correlated with glucose and CRP, and significantly positively correlated with leptin, in all subjects (n = 110). When subjected to multiple regression analysis, none of these variables were predictive of serum cartonectin (P>0.05). There were no significant correlations in T2DM subjects (n = 47). In control subjects (n = 63), serum cartonectin was significantly negatively correlated with CRP, and significantly positively correlated with insulin, HOMA-IR and leptin. However, when subjected to multiple regression analysis, none of these variables were predictive of serum cartonectin (P>0.05). Finally, serum cartonectin concentrations were significantly lower in T2DM subjects after a 2 hour 75 g OGTT (P<0.01).
Cartonectin may serve as a novel biomarker for the prediction and early diagnosis of T2DM patients. Furthermore, cartonectin and/or pharmacological agents that increase circulating cartonectin levels can represent a new therapeutic field in the treatment of T2DM patients. Further research is needed to clarify these points.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0112931</identifier><identifier>PMID: 25409499</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Angina pectoris ; Atherosclerosis ; Bans ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Blood pressure ; Body mass ; Calcification ; Cholesterol ; Complement component C1q ; Correlation ; Cross-Sectional Studies ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - diagnosis ; Enzyme-linked immunosorbent assay ; Fasting ; Female ; Glucose ; Glucose - administration & dosage ; Glucose - metabolism ; Glucose tolerance ; Glucose Tolerance Test ; Hormones ; Hospitals ; Humans ; In vivo methods and tests ; Inflammation ; Infrared radiation ; Insulin ; Insulin resistance ; Leptin ; Male ; Medical schools ; Medicine and Health Sciences ; Metabolic disorders ; Metabolic syndrome ; Middle Aged ; Mortality ; Multiple regression analysis ; Neurobiology ; Neurosciences ; Patients ; Pharmacology ; Polycystic ovary syndrome ; Predictions ; Proteins ; Regression analysis ; Rodents ; Smooth muscle ; Stem cells ; Triglycerides ; Tumor necrosis factor ; Tumor Necrosis Factors - blood ; Womens health</subject><ispartof>PloS one, 2014-11, Vol.9 (11), p.e112931-e112931</ispartof><rights>2014 Ban et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Ban et al 2014 Ban et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-ecc367ed91402d0eb7cd52d23460b261540960be4ddca0af8ef8667e6f34c1fb3</citedby><cites>FETCH-LOGICAL-c526t-ecc367ed91402d0eb7cd52d23460b261540960be4ddca0af8ef8667e6f34c1fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237345/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237345/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2932,23875,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25409499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cui, Ranji</contributor><creatorcontrib>Ban, Bo</creatorcontrib><creatorcontrib>Bai, Bo</creatorcontrib><creatorcontrib>Zhang, Manman</creatorcontrib><creatorcontrib>Hu, Jiamiao</creatorcontrib><creatorcontrib>Ramanjaneya, Manjunath</creatorcontrib><creatorcontrib>Tan, Bee K</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><title>Low serum cartonectin/CTRP3 concentrations in newly diagnosed type 2 diabetes mellitus: in vivo regulation of cartonectin by glucose</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Cartonectin is a novel adipokine of the C1q complement/TNF-related protein (CTRP) superfamily, with glucose lowering effects, anti-inflammatory and cardio-protective properties. We sought to investigate circulating cartonectin concentrations in subjects with type 2 diabetes mellitus (T2DM) as well as age and BMI matched control subjects. We also examined the effects of a 2 hour 75 g oral glucose tolerance test (OGTT) on serum cartonectin concentrations in T2DM subjects.
Cross-sectional study [newly diagnosed (first discovery, not on any treatments) T2DM (n = 47) and control (n = 63) subjects]. Serum cartonectin was measured by ELISA.
Serum cartonectin concentrations were significantly lower in patients with T2DM compared to controls (P<0.05). Furthermore, serum cartonectin was significantly negatively correlated with glucose and CRP, and significantly positively correlated with leptin, in all subjects (n = 110). When subjected to multiple regression analysis, none of these variables were predictive of serum cartonectin (P>0.05). There were no significant correlations in T2DM subjects (n = 47). In control subjects (n = 63), serum cartonectin was significantly negatively correlated with CRP, and significantly positively correlated with insulin, HOMA-IR and leptin. However, when subjected to multiple regression analysis, none of these variables were predictive of serum cartonectin (P>0.05). Finally, serum cartonectin concentrations were significantly lower in T2DM subjects after a 2 hour 75 g OGTT (P<0.01).
Cartonectin may serve as a novel biomarker for the prediction and early diagnosis of T2DM patients. Furthermore, cartonectin and/or pharmacological agents that increase circulating cartonectin levels can represent a new therapeutic field in the treatment of T2DM patients. Further research is needed to clarify these points.</description><subject>Adult</subject><subject>Angina pectoris</subject><subject>Atherosclerosis</subject><subject>Bans</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood pressure</subject><subject>Body mass</subject><subject>Calcification</subject><subject>Cholesterol</subject><subject>Complement component C1q</subject><subject>Correlation</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Fasting</subject><subject>Female</subject><subject>Glucose</subject><subject>Glucose - administration & dosage</subject><subject>Glucose - metabolism</subject><subject>Glucose tolerance</subject><subject>Glucose Tolerance Test</subject><subject>Hormones</subject><subject>Hospitals</subject><subject>Humans</subject><subject>In vivo methods and tests</subject><subject>Inflammation</subject><subject>Infrared radiation</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Leptin</subject><subject>Male</subject><subject>Medical schools</subject><subject>Medicine and Health Sciences</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multiple regression analysis</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>Patients</subject><subject>Pharmacology</subject><subject>Polycystic ovary syndrome</subject><subject>Predictions</subject><subject>Proteins</subject><subject>Regression analysis</subject><subject>Rodents</subject><subject>Smooth muscle</subject><subject>Stem cells</subject><subject>Triglycerides</subject><subject>Tumor necrosis factor</subject><subject>Tumor Necrosis Factors - 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blood</topic><topic>Blood pressure</topic><topic>Body mass</topic><topic>Calcification</topic><topic>Cholesterol</topic><topic>Complement component C1q</topic><topic>Correlation</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Fasting</topic><topic>Female</topic><topic>Glucose</topic><topic>Glucose - administration & dosage</topic><topic>Glucose - metabolism</topic><topic>Glucose tolerance</topic><topic>Glucose Tolerance Test</topic><topic>Hormones</topic><topic>Hospitals</topic><topic>Humans</topic><topic>In vivo methods and tests</topic><topic>Inflammation</topic><topic>Infrared radiation</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Leptin</topic><topic>Male</topic><topic>Medical schools</topic><topic>Medicine and Health Sciences</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Multiple regression analysis</topic><topic>Neurobiology</topic><topic>Neurosciences</topic><topic>Patients</topic><topic>Pharmacology</topic><topic>Polycystic ovary syndrome</topic><topic>Predictions</topic><topic>Proteins</topic><topic>Regression analysis</topic><topic>Rodents</topic><topic>Smooth muscle</topic><topic>Stem cells</topic><topic>Triglycerides</topic><topic>Tumor necrosis factor</topic><topic>Tumor Necrosis Factors - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ban, Bo</au><au>Bai, Bo</au><au>Zhang, Manman</au><au>Hu, Jiamiao</au><au>Ramanjaneya, Manjunath</au><au>Tan, Bee K</au><au>Chen, Jing</au><au>Cui, Ranji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low serum cartonectin/CTRP3 concentrations in newly diagnosed type 2 diabetes mellitus: in vivo regulation of cartonectin by glucose</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-11-19</date><risdate>2014</risdate><volume>9</volume><issue>11</issue><spage>e112931</spage><epage>e112931</epage><pages>e112931-e112931</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Cartonectin is a novel adipokine of the C1q complement/TNF-related protein (CTRP) superfamily, with glucose lowering effects, anti-inflammatory and cardio-protective properties. We sought to investigate circulating cartonectin concentrations in subjects with type 2 diabetes mellitus (T2DM) as well as age and BMI matched control subjects. We also examined the effects of a 2 hour 75 g oral glucose tolerance test (OGTT) on serum cartonectin concentrations in T2DM subjects.
Cross-sectional study [newly diagnosed (first discovery, not on any treatments) T2DM (n = 47) and control (n = 63) subjects]. Serum cartonectin was measured by ELISA.
Serum cartonectin concentrations were significantly lower in patients with T2DM compared to controls (P<0.05). Furthermore, serum cartonectin was significantly negatively correlated with glucose and CRP, and significantly positively correlated with leptin, in all subjects (n = 110). When subjected to multiple regression analysis, none of these variables were predictive of serum cartonectin (P>0.05). There were no significant correlations in T2DM subjects (n = 47). In control subjects (n = 63), serum cartonectin was significantly negatively correlated with CRP, and significantly positively correlated with insulin, HOMA-IR and leptin. However, when subjected to multiple regression analysis, none of these variables were predictive of serum cartonectin (P>0.05). Finally, serum cartonectin concentrations were significantly lower in T2DM subjects after a 2 hour 75 g OGTT (P<0.01).
Cartonectin may serve as a novel biomarker for the prediction and early diagnosis of T2DM patients. Furthermore, cartonectin and/or pharmacological agents that increase circulating cartonectin levels can represent a new therapeutic field in the treatment of T2DM patients. Further research is needed to clarify these points.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25409499</pmid><doi>10.1371/journal.pone.0112931</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-11, Vol.9 (11), p.e112931-e112931 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1980725684 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Angina pectoris Atherosclerosis Bans Biology and Life Sciences Biomarkers Biomarkers - blood Blood pressure Body mass Calcification Cholesterol Complement component C1q Correlation Cross-Sectional Studies Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - diagnosis Enzyme-linked immunosorbent assay Fasting Female Glucose Glucose - administration & dosage Glucose - metabolism Glucose tolerance Glucose Tolerance Test Hormones Hospitals Humans In vivo methods and tests Inflammation Infrared radiation Insulin Insulin resistance Leptin Male Medical schools Medicine and Health Sciences Metabolic disorders Metabolic syndrome Middle Aged Mortality Multiple regression analysis Neurobiology Neurosciences Patients Pharmacology Polycystic ovary syndrome Predictions Proteins Regression analysis Rodents Smooth muscle Stem cells Triglycerides Tumor necrosis factor Tumor Necrosis Factors - blood Womens health |
| title | Low serum cartonectin/CTRP3 concentrations in newly diagnosed type 2 diabetes mellitus: in vivo regulation of cartonectin by glucose |
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