Genome editing in mouse spermatogonial stem/progenitor cells using engineered nucleases

Editing the genome to create specific sequence modifications is a powerful way to study gene function and promises future applicability to gene therapy. Creation of precise modifications requires homologous recombination, a very rare event in most cell types that can be stimulated by introducing a d...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e112652-e112652
Hauptverfasser:	Fanslow, Danielle A, Wirt, Stacey E, Barker, Jenny C, Connelly, Jon P, Porteus, Matthew H, Dann, Christina Tenenhaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Stem Cells - metabolism Adult Stem Cells - transplantation Animals Biochemistry Biology and Life Sciences Cell Line Cells (biology) Customization Deoxyribonucleic acid DNA DNA repair Editing Endonucleases - metabolism Gene therapy Genetic Engineering - methods Genome editing Genomes Homologous recombination Homology Laboratories Male Medicine and Health Sciences Mice Mutation Nuclease Nucleotide sequence Pediatrics Phenotype Pluripotency Research and Analysis Methods Spermatozoa - cytology Stem Cell Transplantation Stem cells Testes Testis - cytology Transplantation
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