New roles of glycosaminoglycans in α-synuclein aggregation in a cellular model of Parkinson disease

The causes of Parkinson disease (PD) remain mysterious, although some evidence supports mitochondrial dysfunctions and α-synuclein accumulation in Lewy bodies as major events. The abnormal accumulation of α-synuclein has been associated with a deficiency in the ubiquitin-proteasome system and the au...

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Veröffentlicht in:	PloS one 2015-01, Vol.10 (1), p.e0116641-e0116641
Hauptverfasser:	Lehri-Boufala, Sonia, Ouidja, Mohand-Ouidir, Barbier-Chassefière, Véronique, Hénault, Emilie, Raisman-Vozari, Rita, Garrigue-Antar, Laure, Papy-Garcia, Dulce, Morin, Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenylpyridinium - pharmacology Accumulation Agglomeration alpha-Synuclein - chemistry alpha-Synuclein - metabolism Amino Acid Sequence Apoptosis Apoptosis - drug effects Biochemistry Biological activity Biosynthesis Cathepsin D Cathepsin D - metabolism Cell Line, Tumor Chondroitin sulfate Degradation Disease Enzymes Gene expression Glycosaminoglycans Glycosaminoglycans - biosynthesis Glycosaminoglycans - metabolism Humans Intracellular Intracellular Space - drug effects Intracellular Space - metabolism Lewy bodies Life Sciences Mitochondria Movement disorders MPP Nervous system Neuroblastoma Neurodegeneration Neurodegenerative diseases Neurons Neurons and Cognition Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Phagocytosis Proteasomes Protein Aggregates - drug effects Protein Transport - drug effects Proteins Proteolysis - drug effects Regulators Rodents Sulfation Synuclein Ubiquitin
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