Effect of pneumococcal conjugate vaccination in Uruguay, a middle-income country
In 2008, a 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into the routine childhood immunization program in Uruguay, with a 2+1 schedule. In 2010, PCV13 replaced PCV7, and the same 2+1 schedule was used. The effect of these pneumococcal vaccines on the incidence of invasive pneumococ...
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| description | In 2008, a 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into the routine childhood immunization program in Uruguay, with a 2+1 schedule. In 2010, PCV13 replaced PCV7, and the same 2+1 schedule was used. The effect of these pneumococcal vaccines on the incidence of invasive pneumococcal infections (IPD) and on serotype distribution was analyzed retrospectively, based on passive national laboratory surveillance.
Data from 1,887 IPD isolates from 5 years before and 5 years after PCV7 introduction (7 before and 3 after PCV13 introduction) was examined to assess the incidence rate per 100,000 age-specific population of all IPD, PCV7-serotypes, and PCV13-serotypes associated IPD among children < 2 years and 2 to 4 years old, and patients ≥ 5 years old. Trends of frequency for each serotype were also analyzed.
Comparison of pre-vaccination (2003-2007) and post-vaccination (2008-2012) periods showed a significant decrease in IPD incidence among children < 2 years old (IR 68.7 to IR 29.6, p |
| doi_str_mv | 10.1371/journal.pone.0112337 |
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Data from 1,887 IPD isolates from 5 years before and 5 years after PCV7 introduction (7 before and 3 after PCV13 introduction) was examined to assess the incidence rate per 100,000 age-specific population of all IPD, PCV7-serotypes, and PCV13-serotypes associated IPD among children < 2 years and 2 to 4 years old, and patients ≥ 5 years old. Trends of frequency for each serotype were also analyzed.
Comparison of pre-vaccination (2003-2007) and post-vaccination (2008-2012) periods showed a significant decrease in IPD incidence among children < 2 years old (IR 68.7 to IR 29.6, p<0.001) and children 2 to 4 years (p < 0.04). IPD caused by serotypes in PCV7 was reduced by 95.6% and IPD caused by 6 serotypes added in PCV13 was reduced by 83.9% in children <5 years old. Indirect effects of both conjugate vaccines were observed among patients ≥ 5 years old one year after the introduction of each vaccine, in 2010 for PCV7 and in 2012 for PCV13. Nevertheless, for reasons that still need to be explained, perhaps due to ascertainment bias, total IPD in this group increased after 2007. In 2012, the relative frequency of vaccine serotypes among vaccinated and unvaccinated population declined, except for serotype 3. Non vaccine serotypes with increasing frequency were identified, in rank order: 12F, 8, 24F, 22F, 24A, 15C, 9N, 10A and 33.
Consecutive immunization with PCV7 and PCV13 has significantly reduced IPD in children < 5 years of age in Uruguay.]]></description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0112337</identifier><identifier>PMID: 25375647</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Analysis ; Biology and Life Sciences ; Child ; Child, Preschool ; Children ; Epidemiology ; Female ; Health aspects ; Health surveillance ; Heptavalent Pneumococcal Conjugate Vaccine - therapeutic use ; Humans ; Immunization ; Incidence ; Infant ; Infection ; Laboratories ; Male ; Medicine and Health Sciences ; Native peoples ; Patients ; Pneumococcal Infections - epidemiology ; Pneumococcal Infections - prevention & control ; Pneumonia ; Population decline ; Public health ; Research and Analysis Methods ; Retrospective Studies ; Serotypes ; Streptococcus infections ; Streptococcus pneumoniae ; Uruguay - epidemiology ; Vaccination ; Vaccines</subject><ispartof>PloS one, 2014-11, Vol.9 (11), p.e112337-e112337</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 García Gabarrot et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 García Gabarrot et al 2014 García Gabarrot et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c828t-44dfad55ab1185a3df32ee03da6254b5a0c2b660c9a15809285b57f07eb2e73c3</citedby><cites>FETCH-LOGICAL-c828t-44dfad55ab1185a3df32ee03da6254b5a0c2b660c9a15809285b57f07eb2e73c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223029/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223029/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25375647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García Gabarrot, Gabriela</creatorcontrib><creatorcontrib>López Vega, Mariana</creatorcontrib><creatorcontrib>Pérez Giffoni, Gabriel</creatorcontrib><creatorcontrib>Hernández, Silvia</creatorcontrib><creatorcontrib>Cardinal, Pablo</creatorcontrib><creatorcontrib>Félix, Viviana</creatorcontrib><creatorcontrib>Gabastou, Jean Marc</creatorcontrib><creatorcontrib>Camou, Teresa</creatorcontrib><creatorcontrib>Uruguayan SIREVA II Group</creatorcontrib><creatorcontrib>the Uruguayan SIREVA II Group</creatorcontrib><title>Effect of pneumococcal conjugate vaccination in Uruguay, a middle-income country</title><title>PloS one</title><addtitle>PLoS One</addtitle><description><![CDATA[In 2008, a 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into the routine childhood immunization program in Uruguay, with a 2+1 schedule. In 2010, PCV13 replaced PCV7, and the same 2+1 schedule was used. The effect of these pneumococcal vaccines on the incidence of invasive pneumococcal infections (IPD) and on serotype distribution was analyzed retrospectively, based on passive national laboratory surveillance.
Data from 1,887 IPD isolates from 5 years before and 5 years after PCV7 introduction (7 before and 3 after PCV13 introduction) was examined to assess the incidence rate per 100,000 age-specific population of all IPD, PCV7-serotypes, and PCV13-serotypes associated IPD among children < 2 years and 2 to 4 years old, and patients ≥ 5 years old. Trends of frequency for each serotype were also analyzed.
Comparison of pre-vaccination (2003-2007) and post-vaccination (2008-2012) periods showed a significant decrease in IPD incidence among children < 2 years old (IR 68.7 to IR 29.6, p<0.001) and children 2 to 4 years (p < 0.04). IPD caused by serotypes in PCV7 was reduced by 95.6% and IPD caused by 6 serotypes added in PCV13 was reduced by 83.9% in children <5 years old. Indirect effects of both conjugate vaccines were observed among patients ≥ 5 years old one year after the introduction of each vaccine, in 2010 for PCV7 and in 2012 for PCV13. Nevertheless, for reasons that still need to be explained, perhaps due to ascertainment bias, total IPD in this group increased after 2007. In 2012, the relative frequency of vaccine serotypes among vaccinated and unvaccinated population declined, except for serotype 3. Non vaccine serotypes with increasing frequency were identified, in rank order: 12F, 8, 24F, 22F, 24A, 15C, 9N, 10A and 33.
Consecutive immunization with PCV7 and PCV13 has significantly reduced IPD in children < 5 years of age in Uruguay.]]></description><subject>Age</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health surveillance</subject><subject>Heptavalent Pneumococcal Conjugate Vaccine - therapeutic use</subject><subject>Humans</subject><subject>Immunization</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infection</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Native peoples</subject><subject>Patients</subject><subject>Pneumococcal Infections - epidemiology</subject><subject>Pneumococcal Infections - prevention & control</subject><subject>Pneumonia</subject><subject>Population decline</subject><subject>Public health</subject><subject>Research and Analysis Methods</subject><subject>Retrospective Studies</subject><subject>Serotypes</subject><subject>Streptococcus infections</subject><subject>Streptococcus pneumoniae</subject><subject>Uruguay - 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therapeutic use</topic><topic>Humans</topic><topic>Immunization</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infection</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Native peoples</topic><topic>Patients</topic><topic>Pneumococcal Infections - epidemiology</topic><topic>Pneumococcal Infections - prevention & control</topic><topic>Pneumonia</topic><topic>Population decline</topic><topic>Public health</topic><topic>Research and Analysis Methods</topic><topic>Retrospective Studies</topic><topic>Serotypes</topic><topic>Streptococcus infections</topic><topic>Streptococcus pneumoniae</topic><topic>Uruguay - epidemiology</topic><topic>Vaccination</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García Gabarrot, Gabriela</creatorcontrib><creatorcontrib>López Vega, Mariana</creatorcontrib><creatorcontrib>Pérez Giffoni, Gabriel</creatorcontrib><creatorcontrib>Hernández, Silvia</creatorcontrib><creatorcontrib>Cardinal, Pablo</creatorcontrib><creatorcontrib>Félix, Viviana</creatorcontrib><creatorcontrib>Gabastou, Jean Marc</creatorcontrib><creatorcontrib>Camou, Teresa</creatorcontrib><creatorcontrib>Uruguayan SIREVA II Group</creatorcontrib><creatorcontrib>the Uruguayan SIREVA II Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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In 2010, PCV13 replaced PCV7, and the same 2+1 schedule was used. The effect of these pneumococcal vaccines on the incidence of invasive pneumococcal infections (IPD) and on serotype distribution was analyzed retrospectively, based on passive national laboratory surveillance.
Data from 1,887 IPD isolates from 5 years before and 5 years after PCV7 introduction (7 before and 3 after PCV13 introduction) was examined to assess the incidence rate per 100,000 age-specific population of all IPD, PCV7-serotypes, and PCV13-serotypes associated IPD among children < 2 years and 2 to 4 years old, and patients ≥ 5 years old. Trends of frequency for each serotype were also analyzed.
Comparison of pre-vaccination (2003-2007) and post-vaccination (2008-2012) periods showed a significant decrease in IPD incidence among children < 2 years old (IR 68.7 to IR 29.6, p<0.001) and children 2 to 4 years (p < 0.04). IPD caused by serotypes in PCV7 was reduced by 95.6% and IPD caused by 6 serotypes added in PCV13 was reduced by 83.9% in children <5 years old. Indirect effects of both conjugate vaccines were observed among patients ≥ 5 years old one year after the introduction of each vaccine, in 2010 for PCV7 and in 2012 for PCV13. Nevertheless, for reasons that still need to be explained, perhaps due to ascertainment bias, total IPD in this group increased after 2007. In 2012, the relative frequency of vaccine serotypes among vaccinated and unvaccinated population declined, except for serotype 3. Non vaccine serotypes with increasing frequency were identified, in rank order: 12F, 8, 24F, 22F, 24A, 15C, 9N, 10A and 33.
Consecutive immunization with PCV7 and PCV13 has significantly reduced IPD in children < 5 years of age in Uruguay.]]></abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25375647</pmid><doi>10.1371/journal.pone.0112337</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-11, Vol.9 (11), p.e112337-e112337 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1979937795 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Analysis Biology and Life Sciences Child Child, Preschool Children Epidemiology Female Health aspects Health surveillance Heptavalent Pneumococcal Conjugate Vaccine - therapeutic use Humans Immunization Incidence Infant Infection Laboratories Male Medicine and Health Sciences Native peoples Patients Pneumococcal Infections - epidemiology Pneumococcal Infections - prevention & control Pneumonia Population decline Public health Research and Analysis Methods Retrospective Studies Serotypes Streptococcus infections Streptococcus pneumoniae Uruguay - epidemiology Vaccination Vaccines |
| title | Effect of pneumococcal conjugate vaccination in Uruguay, a middle-income country |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T00%3A33%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20pneumococcal%20conjugate%20vaccination%20in%20Uruguay,%20a%20middle-income%20country&rft.jtitle=PloS%20one&rft.au=Garc%C3%ADa%20Gabarrot,%20Gabriela&rft.aucorp=Uruguayan%20SIREVA%20II%20Group&rft.date=2014-11-06&rft.volume=9&rft.issue=11&rft.spage=e112337&rft.epage=e112337&rft.pages=e112337-e112337&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0112337&rft_dat=%3Cgale_plos_%3EA418707013%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1979937795&rft_id=info:pmid/25375647&rft_galeid=A418707013&rft_doaj_id=oai_doaj_org_article_1c058dddd38f435e83dd86610aefa40c&rfr_iscdi=true |