Magnetic resonance imaging (MRI) to study striatal iron accumulation in a rat model of Parkinson's disease
Abnormal accumulation of iron is observed in neurodegenerative disorders. In Parkinson's disease, an excess of iron has been demonstrated in different structures of the basal ganglia and is suggested to be involved in the pathogenesis of the disease. Using the 6-hydroxydopamine (6-OHDA) rat mod...
Gespeichert in:
| Veröffentlicht in: | PloS one 2014-11, Vol.9 (11), p.e112941-e112941 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e112941 |
|---|---|
| container_issue | 11 |
| container_start_page | e112941 |
| container_title | PloS one |
| container_volume | 9 |
| creator | Virel, Ana Faergemann, Erik Orädd, Greger Strömberg, Ingrid |
| description | Abnormal accumulation of iron is observed in neurodegenerative disorders. In Parkinson's disease, an excess of iron has been demonstrated in different structures of the basal ganglia and is suggested to be involved in the pathogenesis of the disease. Using the 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease, the edematous effect of 6-OHDA and its relation with striatal iron accumulation was examined utilizing in vivo magnetic resonance imaging (MRI). The results revealed that in comparison with control animals, injection of 6-OHDA into the rat striatum provoked an edematous process, visible in T2-weighted images that was accompanied by an accumulation of iron clearly detectable in T2*-weighted images. Furthermore, Prussian blue staining to detect iron in sectioned brains confirmed the existence of accumulated iron in the areas of T2* hypointensities. The presence of ED1-positive microglia in the lesioned striatum overlapped with this accumulation of iron, indicating areas of toxicity and loss of dopamine nerve fibers. Correlation analyses demonstrated a direct relation between the hyperintensities caused by the edema and the hypointensities caused by the accumulation of iron. |
| doi_str_mv | 10.1371/journal.pone.0112941 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1979937526</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A418529705</galeid><doaj_id>oai_doaj_org_article_608d164f3f71482ead51daed06bf11eb</doaj_id><sourcerecordid>A418529705</sourcerecordid><originalsourceid>FETCH-LOGICAL-c630t-f0372dfa8c41409bd15d08d487848a2a508807bcda419d6f6cfe23c3381927e63</originalsourceid><addsrcrecordid>eNptUltrFDEYHUSxdfUfiAZ8sIK75jYzmRdhqbdCiyLqa_gmlzHrTLImM0r_vdnutHSlBHI95-T7DqconhK8IqwmbzZhih761TZ4s8KE0IaTe8UxaRhdVhSz-7f2R8WjlDYYl0xU1cPiiJasEViI42JzAZ03o1MomhQ8eGWQG6BzvkMnF1_PXqExoDRO-jLP0cEIPXIxeARKTcPUw-jyweUzijCiIWjTo2DRF4i_nM-KLxPSLhlI5nHxwEKfzJN5XRTfP7z_dvppef7549np-nypKobHpcWsptqCUJxw3LSalBoLzUUtuAAKZa4b163SwEmjK1spayhTjAnS0NpUbFE83-tu-5DkbFOSpKmbhtUl3SHO9ggdYCO3MTccL2UAJ68uQuwkxOxJb2SVvyYVt8zWhAtqQJdEg9G4ai0hps1ar_da6a_ZTu2B2jv3Y32llp2SjeCcZPjbubipHYxWxo8R-gPW4Yt3P2UX_khOGS0FzQIns0AMvyeTRjm4pEzfgzdhym1WVGSDGK8z9MV_0LvNmFEd5H6dtyH_q3aics2JKGlT59wsitUdqDy0GZzKEbQu3x8Q-J6gYkgpGnvTI8FyF-DrYuQuwHIOcKY9u-3PDek6sewfha3tiw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1979937526</pqid></control><display><type>article</type><title>Magnetic resonance imaging (MRI) to study striatal iron accumulation in a rat model of Parkinson's disease</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SWEPUB Freely available online</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Virel, Ana ; Faergemann, Erik ; Orädd, Greger ; Strömberg, Ingrid</creator><creatorcontrib>Virel, Ana ; Faergemann, Erik ; Orädd, Greger ; Strömberg, Ingrid</creatorcontrib><description>Abnormal accumulation of iron is observed in neurodegenerative disorders. In Parkinson's disease, an excess of iron has been demonstrated in different structures of the basal ganglia and is suggested to be involved in the pathogenesis of the disease. Using the 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease, the edematous effect of 6-OHDA and its relation with striatal iron accumulation was examined utilizing in vivo magnetic resonance imaging (MRI). The results revealed that in comparison with control animals, injection of 6-OHDA into the rat striatum provoked an edematous process, visible in T2-weighted images that was accompanied by an accumulation of iron clearly detectable in T2*-weighted images. Furthermore, Prussian blue staining to detect iron in sectioned brains confirmed the existence of accumulated iron in the areas of T2* hypointensities. The presence of ED1-positive microglia in the lesioned striatum overlapped with this accumulation of iron, indicating areas of toxicity and loss of dopamine nerve fibers. Correlation analyses demonstrated a direct relation between the hyperintensities caused by the edema and the hypointensities caused by the accumulation of iron.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0112941</identifier><identifier>PMID: 25398088</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>6-Hydroxydopamine ; Accumulation ; Adrenergic Agents - pharmacology ; Adrenergic Agents - therapeutic use ; Animals ; Basal ganglia ; Biocompatibility ; Biology ; Blood-brain barrier ; Brain ; Corpus Striatum - diagnostic imaging ; Corpus Striatum - drug effects ; Corpus Striatum - metabolism ; Correlation analysis ; Disease ; Disease Models, Animal ; Dopamine ; Edema ; Female ; Ganglia ; Image detection ; Immunohistochemistry ; Iron ; Iron - metabolism ; Iron compounds ; Magnetic fields ; Magnetic resonance ; Magnetic Resonance Imaging ; Medical research ; Medicine and Health Sciences ; Microglia ; Neostriatum ; Neurodegeneration ; Neurodegenerative diseases ; NMR ; Nuclear magnetic resonance ; Oxidopamine - pharmacology ; Oxidopamine - therapeutic use ; Parkinson Disease - drug therapy ; Parkinson Disease - metabolism ; Parkinson Disease - pathology ; Parkinson's disease ; Parkinsons disease ; Pathogenesis ; Pigments ; Radiography ; Rats ; Rats, Sprague-Dawley ; Resonance ; Rodents ; Studies ; Toxicity</subject><ispartof>PloS one, 2014-11, Vol.9 (11), p.e112941-e112941</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Virel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Virel et al 2014 Virel et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c630t-f0372dfa8c41409bd15d08d487848a2a508807bcda419d6f6cfe23c3381927e63</citedby><cites>FETCH-LOGICAL-c630t-f0372dfa8c41409bd15d08d487848a2a508807bcda419d6f6cfe23c3381927e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232582/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232582/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25398088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-98441$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Virel, Ana</creatorcontrib><creatorcontrib>Faergemann, Erik</creatorcontrib><creatorcontrib>Orädd, Greger</creatorcontrib><creatorcontrib>Strömberg, Ingrid</creatorcontrib><title>Magnetic resonance imaging (MRI) to study striatal iron accumulation in a rat model of Parkinson's disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Abnormal accumulation of iron is observed in neurodegenerative disorders. In Parkinson's disease, an excess of iron has been demonstrated in different structures of the basal ganglia and is suggested to be involved in the pathogenesis of the disease. Using the 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease, the edematous effect of 6-OHDA and its relation with striatal iron accumulation was examined utilizing in vivo magnetic resonance imaging (MRI). The results revealed that in comparison with control animals, injection of 6-OHDA into the rat striatum provoked an edematous process, visible in T2-weighted images that was accompanied by an accumulation of iron clearly detectable in T2*-weighted images. Furthermore, Prussian blue staining to detect iron in sectioned brains confirmed the existence of accumulated iron in the areas of T2* hypointensities. The presence of ED1-positive microglia in the lesioned striatum overlapped with this accumulation of iron, indicating areas of toxicity and loss of dopamine nerve fibers. Correlation analyses demonstrated a direct relation between the hyperintensities caused by the edema and the hypointensities caused by the accumulation of iron.</description><subject>6-Hydroxydopamine</subject><subject>Accumulation</subject><subject>Adrenergic Agents - pharmacology</subject><subject>Adrenergic Agents - therapeutic use</subject><subject>Animals</subject><subject>Basal ganglia</subject><subject>Biocompatibility</subject><subject>Biology</subject><subject>Blood-brain barrier</subject><subject>Brain</subject><subject>Corpus Striatum - diagnostic imaging</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - metabolism</subject><subject>Correlation analysis</subject><subject>Disease</subject><subject>Disease Models, Animal</subject><subject>Dopamine</subject><subject>Edema</subject><subject>Female</subject><subject>Ganglia</subject><subject>Image detection</subject><subject>Immunohistochemistry</subject><subject>Iron</subject><subject>Iron - metabolism</subject><subject>Iron compounds</subject><subject>Magnetic fields</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Microglia</subject><subject>Neostriatum</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oxidopamine - pharmacology</subject><subject>Oxidopamine - therapeutic use</subject><subject>Parkinson Disease - drug therapy</subject><subject>Parkinson Disease - metabolism</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson's disease</subject><subject>Parkinsons disease</subject><subject>Pathogenesis</subject><subject>Pigments</subject><subject>Radiography</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Resonance</subject><subject>Rodents</subject><subject>Studies</subject><subject>Toxicity</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><sourceid>DOA</sourceid><recordid>eNptUltrFDEYHUSxdfUfiAZ8sIK75jYzmRdhqbdCiyLqa_gmlzHrTLImM0r_vdnutHSlBHI95-T7DqconhK8IqwmbzZhih761TZ4s8KE0IaTe8UxaRhdVhSz-7f2R8WjlDYYl0xU1cPiiJasEViI42JzAZ03o1MomhQ8eGWQG6BzvkMnF1_PXqExoDRO-jLP0cEIPXIxeARKTcPUw-jyweUzijCiIWjTo2DRF4i_nM-KLxPSLhlI5nHxwEKfzJN5XRTfP7z_dvppef7549np-nypKobHpcWsptqCUJxw3LSalBoLzUUtuAAKZa4b163SwEmjK1spayhTjAnS0NpUbFE83-tu-5DkbFOSpKmbhtUl3SHO9ggdYCO3MTccL2UAJ68uQuwkxOxJb2SVvyYVt8zWhAtqQJdEg9G4ai0hps1ar_da6a_ZTu2B2jv3Y32llp2SjeCcZPjbubipHYxWxo8R-gPW4Yt3P2UX_khOGS0FzQIns0AMvyeTRjm4pEzfgzdhym1WVGSDGK8z9MV_0LvNmFEd5H6dtyH_q3aics2JKGlT59wsitUdqDy0GZzKEbQu3x8Q-J6gYkgpGnvTI8FyF-DrYuQuwHIOcKY9u-3PDek6sewfha3tiw</recordid><startdate>20141114</startdate><enddate>20141114</enddate><creator>Virel, Ana</creator><creator>Faergemann, Erik</creator><creator>Orädd, Greger</creator><creator>Strömberg, Ingrid</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>ADHXS</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>D93</scope><scope>ZZAVC</scope><scope>DOA</scope></search><sort><creationdate>20141114</creationdate><title>Magnetic resonance imaging (MRI) to study striatal iron accumulation in a rat model of Parkinson's disease</title><author>Virel, Ana ; Faergemann, Erik ; Orädd, Greger ; Strömberg, Ingrid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c630t-f0372dfa8c41409bd15d08d487848a2a508807bcda419d6f6cfe23c3381927e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>6-Hydroxydopamine</topic><topic>Accumulation</topic><topic>Adrenergic Agents - pharmacology</topic><topic>Adrenergic Agents - therapeutic use</topic><topic>Animals</topic><topic>Basal ganglia</topic><topic>Biocompatibility</topic><topic>Biology</topic><topic>Blood-brain barrier</topic><topic>Brain</topic><topic>Corpus Striatum - diagnostic imaging</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - metabolism</topic><topic>Correlation analysis</topic><topic>Disease</topic><topic>Disease Models, Animal</topic><topic>Dopamine</topic><topic>Edema</topic><topic>Female</topic><topic>Ganglia</topic><topic>Image detection</topic><topic>Immunohistochemistry</topic><topic>Iron</topic><topic>Iron - metabolism</topic><topic>Iron compounds</topic><topic>Magnetic fields</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Microglia</topic><topic>Neostriatum</topic><topic>Neurodegeneration</topic><topic>Neurodegenerative diseases</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Oxidopamine - pharmacology</topic><topic>Oxidopamine - therapeutic use</topic><topic>Parkinson Disease - drug therapy</topic><topic>Parkinson Disease - metabolism</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson's disease</topic><topic>Parkinsons disease</topic><topic>Pathogenesis</topic><topic>Pigments</topic><topic>Radiography</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Resonance</topic><topic>Rodents</topic><topic>Studies</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Virel, Ana</creatorcontrib><creatorcontrib>Faergemann, Erik</creatorcontrib><creatorcontrib>Orädd, Greger</creatorcontrib><creatorcontrib>Strömberg, Ingrid</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Umeå universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Umeå universitet</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Virel, Ana</au><au>Faergemann, Erik</au><au>Orädd, Greger</au><au>Strömberg, Ingrid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance imaging (MRI) to study striatal iron accumulation in a rat model of Parkinson's disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-11-14</date><risdate>2014</risdate><volume>9</volume><issue>11</issue><spage>e112941</spage><epage>e112941</epage><pages>e112941-e112941</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Abnormal accumulation of iron is observed in neurodegenerative disorders. In Parkinson's disease, an excess of iron has been demonstrated in different structures of the basal ganglia and is suggested to be involved in the pathogenesis of the disease. Using the 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease, the edematous effect of 6-OHDA and its relation with striatal iron accumulation was examined utilizing in vivo magnetic resonance imaging (MRI). The results revealed that in comparison with control animals, injection of 6-OHDA into the rat striatum provoked an edematous process, visible in T2-weighted images that was accompanied by an accumulation of iron clearly detectable in T2*-weighted images. Furthermore, Prussian blue staining to detect iron in sectioned brains confirmed the existence of accumulated iron in the areas of T2* hypointensities. The presence of ED1-positive microglia in the lesioned striatum overlapped with this accumulation of iron, indicating areas of toxicity and loss of dopamine nerve fibers. Correlation analyses demonstrated a direct relation between the hyperintensities caused by the edema and the hypointensities caused by the accumulation of iron.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25398088</pmid><doi>10.1371/journal.pone.0112941</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-11, Vol.9 (11), p.e112941-e112941 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1979937526 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | 6-Hydroxydopamine Accumulation Adrenergic Agents - pharmacology Adrenergic Agents - therapeutic use Animals Basal ganglia Biocompatibility Biology Blood-brain barrier Brain Corpus Striatum - diagnostic imaging Corpus Striatum - drug effects Corpus Striatum - metabolism Correlation analysis Disease Disease Models, Animal Dopamine Edema Female Ganglia Image detection Immunohistochemistry Iron Iron - metabolism Iron compounds Magnetic fields Magnetic resonance Magnetic Resonance Imaging Medical research Medicine and Health Sciences Microglia Neostriatum Neurodegeneration Neurodegenerative diseases NMR Nuclear magnetic resonance Oxidopamine - pharmacology Oxidopamine - therapeutic use Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Parkinsons disease Pathogenesis Pigments Radiography Rats Rats, Sprague-Dawley Resonance Rodents Studies Toxicity |
| title | Magnetic resonance imaging (MRI) to study striatal iron accumulation in a rat model of Parkinson's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T19%3A57%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Magnetic%20resonance%20imaging%20(MRI)%20to%20study%20striatal%20iron%20accumulation%20in%20a%20rat%20model%20of%20Parkinson's%20disease&rft.jtitle=PloS%20one&rft.au=Virel,%20Ana&rft.date=2014-11-14&rft.volume=9&rft.issue=11&rft.spage=e112941&rft.epage=e112941&rft.pages=e112941-e112941&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0112941&rft_dat=%3Cgale_plos_%3EA418529705%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1979937526&rft_id=info:pmid/25398088&rft_galeid=A418529705&rft_doaj_id=oai_doaj_org_article_608d164f3f71482ead51daed06bf11eb&rfr_iscdi=true |