L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts
Flor yeasts of Saccharomyces cerevisiae have an innate diversity of Flo11p which codes for a highly hydrophobic and anionic cell-wall glycoprotein with a fundamental role in biofilm formation. In this study, 380 nitrogen compounds were administered to three S. cerevisiae flor strains handling Flo11p...
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| Veröffentlicht in: | PloS one 2014-11, Vol.9 (11), p.e112141-e112141 |
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| creator | Bou Zeidan, Marc Zara, Giacomo Viti, Carlo Decorosi, Francesca Mannazzu, Ilaria Budroni, Marilena Giovannetti, Luciana Zara, Severino |
| description | Flor yeasts of Saccharomyces cerevisiae have an innate diversity of Flo11p which codes for a highly hydrophobic and anionic cell-wall glycoprotein with a fundamental role in biofilm formation. In this study, 380 nitrogen compounds were administered to three S. cerevisiae flor strains handling Flo11p alleles with different expression levels. S. cerevisiae strain S288c was used as the reference strain as it cannot produce Flo11p. The flor strains generally metabolized amino acids and dipeptides as the sole nitrogen source, although with some exceptions regarding L-histidine and histidine containing dipeptides. L-histidine completely inhibited growth and its effect on viability was inversely related to Flo11p expression. Accordingly, L-histidine did not affect the viability of the Δflo11 and S288c strains. Also, L-histidine dramatically decreased air-liquid biofilm formation and adhesion to polystyrene of the flor yeasts with no effect on the transcription level of the Flo11p gene. Moreover, L-histidine modified the chitin and glycans content on the cell-wall of flor yeasts. These findings reveal a novel biological activity of L-histidine in controlling the multicellular behavior of yeasts [corrected]. |
| doi_str_mv | 10.1371/journal.pone.0112141 |
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In this study, 380 nitrogen compounds were administered to three S. cerevisiae flor strains handling Flo11p alleles with different expression levels. S. cerevisiae strain S288c was used as the reference strain as it cannot produce Flo11p. The flor strains generally metabolized amino acids and dipeptides as the sole nitrogen source, although with some exceptions regarding L-histidine and histidine containing dipeptides. L-histidine completely inhibited growth and its effect on viability was inversely related to Flo11p expression. Accordingly, L-histidine did not affect the viability of the Δflo11 and S288c strains. Also, L-histidine dramatically decreased air-liquid biofilm formation and adhesion to polystyrene of the flor yeasts with no effect on the transcription level of the Flo11p gene. Moreover, L-histidine modified the chitin and glycans content on the cell-wall of flor yeasts. These findings reveal a novel biological activity of L-histidine in controlling the multicellular behavior of yeasts [corrected].</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0112141</identifier><identifier>PMID: 25369456</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amino acids ; Biofilms ; Biological activity ; Biology and Life Sciences ; Candida albicans ; Cell culture ; Cell Wall - metabolism ; Cell walls ; Chitin ; Cluster Analysis ; FLO11 gene ; Gene expression ; Glycoproteins ; Histidine ; Histidine - metabolism ; Histidine - pharmacology ; Hydrogen-Ion Concentration ; Hydrophobicity ; Membrane Glycoproteins - physiology ; Metabolic Networks and Pathways ; Metabolism ; Microbial Viability - drug effects ; Nitrogen ; Nitrogen compounds ; Phenotype ; Polysaccharides ; Polystyrene ; Polystyrene resins ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - drug effects ; Saccharomyces cerevisiae - physiology ; Saccharomyces cerevisiae Proteins - physiology ; Transcription ; Viability ; Yeast ; Yeasts</subject><ispartof>PloS one, 2014-11, Vol.9 (11), p.e112141-e112141</ispartof><rights>2014 Bou Zeidan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Bou Zeidan et al 2014 Bou Zeidan et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c802t-5c6c66ad2b666531348ff8b487584d0cb5699fc0f0b6758c060e88d946558e4a3</citedby><cites>FETCH-LOGICAL-c802t-5c6c66ad2b666531348ff8b487584d0cb5699fc0f0b6758c060e88d946558e4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219837/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219837/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25369456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Galli, Alvaro</contributor><creatorcontrib>Bou Zeidan, Marc</creatorcontrib><creatorcontrib>Zara, Giacomo</creatorcontrib><creatorcontrib>Viti, Carlo</creatorcontrib><creatorcontrib>Decorosi, Francesca</creatorcontrib><creatorcontrib>Mannazzu, Ilaria</creatorcontrib><creatorcontrib>Budroni, Marilena</creatorcontrib><creatorcontrib>Giovannetti, Luciana</creatorcontrib><creatorcontrib>Zara, Severino</creatorcontrib><title>L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Flor yeasts of Saccharomyces cerevisiae have an innate diversity of Flo11p which codes for a highly hydrophobic and anionic cell-wall glycoprotein with a fundamental role in biofilm formation. In this study, 380 nitrogen compounds were administered to three S. cerevisiae flor strains handling Flo11p alleles with different expression levels. S. cerevisiae strain S288c was used as the reference strain as it cannot produce Flo11p. The flor strains generally metabolized amino acids and dipeptides as the sole nitrogen source, although with some exceptions regarding L-histidine and histidine containing dipeptides. L-histidine completely inhibited growth and its effect on viability was inversely related to Flo11p expression. Accordingly, L-histidine did not affect the viability of the Δflo11 and S288c strains. Also, L-histidine dramatically decreased air-liquid biofilm formation and adhesion to polystyrene of the flor yeasts with no effect on the transcription level of the Flo11p gene. Moreover, L-histidine modified the chitin and glycans content on the cell-wall of flor yeasts. These findings reveal a novel biological activity of L-histidine in controlling the multicellular behavior of yeasts [corrected].</description><subject>Amino acids</subject><subject>Biofilms</subject><subject>Biological activity</subject><subject>Biology and Life Sciences</subject><subject>Candida albicans</subject><subject>Cell culture</subject><subject>Cell Wall - metabolism</subject><subject>Cell walls</subject><subject>Chitin</subject><subject>Cluster Analysis</subject><subject>FLO11 gene</subject><subject>Gene expression</subject><subject>Glycoproteins</subject><subject>Histidine</subject><subject>Histidine - metabolism</subject><subject>Histidine - pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hydrophobicity</subject><subject>Membrane Glycoproteins - physiology</subject><subject>Metabolic Networks and Pathways</subject><subject>Metabolism</subject><subject>Microbial Viability - drug effects</subject><subject>Nitrogen</subject><subject>Nitrogen compounds</subject><subject>Phenotype</subject><subject>Polysaccharides</subject><subject>Polystyrene</subject><subject>Polystyrene resins</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bou Zeidan, Marc</au><au>Zara, Giacomo</au><au>Viti, Carlo</au><au>Decorosi, Francesca</au><au>Mannazzu, Ilaria</au><au>Budroni, Marilena</au><au>Giovannetti, Luciana</au><au>Zara, Severino</au><au>Galli, Alvaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-11-04</date><risdate>2014</risdate><volume>9</volume><issue>11</issue><spage>e112141</spage><epage>e112141</epage><pages>e112141-e112141</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Flor yeasts of Saccharomyces cerevisiae have an innate diversity of Flo11p which codes for a highly hydrophobic and anionic cell-wall glycoprotein with a fundamental role in biofilm formation. In this study, 380 nitrogen compounds were administered to three S. cerevisiae flor strains handling Flo11p alleles with different expression levels. S. cerevisiae strain S288c was used as the reference strain as it cannot produce Flo11p. The flor strains generally metabolized amino acids and dipeptides as the sole nitrogen source, although with some exceptions regarding L-histidine and histidine containing dipeptides. L-histidine completely inhibited growth and its effect on viability was inversely related to Flo11p expression. Accordingly, L-histidine did not affect the viability of the Δflo11 and S288c strains. Also, L-histidine dramatically decreased air-liquid biofilm formation and adhesion to polystyrene of the flor yeasts with no effect on the transcription level of the Flo11p gene. Moreover, L-histidine modified the chitin and glycans content on the cell-wall of flor yeasts. These findings reveal a novel biological activity of L-histidine in controlling the multicellular behavior of yeasts [corrected].</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25369456</pmid><doi>10.1371/journal.pone.0112141</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Amino acids Biofilms Biological activity Biology and Life Sciences Candida albicans Cell culture Cell Wall - metabolism Cell walls Chitin Cluster Analysis FLO11 gene Gene expression Glycoproteins Histidine Histidine - metabolism Histidine - pharmacology Hydrogen-Ion Concentration Hydrophobicity Membrane Glycoproteins - physiology Metabolic Networks and Pathways Metabolism Microbial Viability - drug effects Nitrogen Nitrogen compounds Phenotype Polysaccharides Polystyrene Polystyrene resins Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - physiology Saccharomyces cerevisiae Proteins - physiology Transcription Viability Yeast Yeasts |
| title | L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts |
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