Enhancement of energy expenditure following a single oral dose of flavan-3-ols associated with an increase in catecholamine secretion

Numerous clinical studies have reported that ingestion of chocolate reduces the risk of metabolic syndrome. However, the mechanisms by which this occurs remain unclear. In this murine study, the metabolic-enhancing activity of a 10 mg/kg mixture of flavan-3-ol fraction derived from cocoa (FL) was co...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e112180-e112180
Hauptverfasser:	Matsumura, Yusuke, Nakagawa, Yuta, Mikome, Katsuyuki, Yamamoto, Hiroki, Osakabe, Naomi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose tissue (brown) Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Administration, Oral AMP AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Anesthesia Animals Bioavailability Biology and Life Sciences Cacao - chemistry Cardiovascular disease Catechin - pharmacology Catecholamine Catecholamines Catecholamines - blood Chemical industry Chocolate Chromatography Cocoa Dehydrogenases Diet Distilled water Endocrinology Energy expenditure Energy Metabolism - drug effects Engineering Epicatechin Epinephrine Experiments Fasting Flavonoids - administration & dosage Gene expression Hypoxia Ingestion Ion Channels - genetics Lipolysis Male Metabolic disorders Metabolic syndrome Metabolism Mice Mice, Inbred ICR Mitochondrial DNA Mitochondrial Proteins - genetics Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Musculoskeletal system Phosphorylation - drug effects Proteins RNA Rodents Science Secretion Thermogenesis Thermogenesis - drug effects Transcription Factors - genetics Uncoupling Protein 1 Water vehicles
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