Exercise-mediated wall shear stress increases mitochondrial biogenesis in vascular endothelium

Enhancing structural and functional integrity of mitochondria is an emerging therapeutic option against endothelial dysfunction. In this study, we sought to investigate the effect of fluid shear stress on mitochondrial biogenesis and mitochondrial respiratory function in endothelial cells (ECs) usin...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e111409-e111409
Hauptverfasser:	Kim, Boa, Lee, Hojun, Kawata, Keisuke, Park, Joon-Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Aorta - metabolism Aortic arch Arteries Biology and Life Sciences Biosynthesis Blood Blood flow Cells, Cultured Curvature Electron transport Endothelial cells Endothelial Cells - metabolism Endothelium Endothelium, Vascular - metabolism Exercise Exposure Femoral artery Femur Fluid flow Gene expression Glycolysis Health aspects Human Umbilical Vein Endothelial Cells Humans In vivo methods and tests Kinases Kinesiology Mechanical stimuli Medicine and Health Sciences Membrane potential Mice Mitochondria Mitochondrial DNA Mitochondrial Turnover - physiology Muscles Physical Conditioning, Animal - physiology Physical fitness Physical training Plates (structural members) Proteins Quality control Respiration Respiratory function Shear stress Shear stresses Stress, Mechanical Structure-function relationships Thorax Umbilical vein Wheel running
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