The indolinone MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells without the inhibition of VEGFR-3 phosphorylation: involvement of the RhoA and Akt/GSK3β signaling pathways

MAZ51 is an indolinone-based molecule originally synthesized as a selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-3 tyrosine kinase. This study shows that exposure of two glioma cell lines, rat C6 and human U251MG, to MAZ51 caused dramatic shape changes, including the retr...

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Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e109055-e109055
Hauptverfasser:	Park, Joo-Hee, Shin, Yoo-Jin, Riew, Tae-Ryong, Lee, Mun-Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin Cytoskeleton - drug effects Actin Cytoskeleton - ultrastructure Activation AKT protein Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Astrocytes Astrocytes - drug effects Astrocytes - metabolism Astrocytes - ultrastructure Biology and Life Sciences Brain cancer Brain tumors Cell cycle Cell death Cell division Cell Line, Tumor Cell lines Cell Proliferation - drug effects Cell Shape - drug effects Cell size Cervical cancer Chemical synthesis Clustering Cortex Cytology Cytoskeleton Filaments G2 Phase Cell Cycle Checkpoints - drug effects Gene Expression Regulation, Neoplastic Glioma Glioma cells Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Humans Immunoprecipitation Indoles - pharmacology Inhibition Kinases Laboratory animals Medical prognosis Medicine Medicine and Health Sciences Metastasis Microtubules Microtubules - drug effects Microtubules - ultrastructure Morphology Naphthalenes - pharmacology Neuroglia - drug effects Neuroglia - metabolism Neuroglia - pathology Neuroglia - ultrastructure Neurosciences Phosphorylation Protein-tyrosine kinase Proto-Oncogene Proteins c-akt - agonists Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rats rhoA GTP-Binding Protein - agonists rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism RhoA protein RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Rounding Signal Transduction Signaling Transformed cells Tyrosine Vascular endothelial growth factor Vascular Endothelial Growth Factor C - pharmacology Vascular Endothelial Growth Factor Receptor-3 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-3 - genetics Vascular Endothelial Growth Factor Receptor-3 - metabolism Vascular endothelial growth factor receptors
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