Monocrotophos pesticide decreases the plasma levels of total 3,3',5-triiodo-l-thyronine and alters the expression of genes associated with the thyroidal axis in female goldfish (Carassius auratus)
Our recent study showed that monocrotophos (MCP) pesticide disrupted the hypothalamic-pituitary-thyroid (HPT) axis in male goldfish (Carassius auratus); however, the effects of MCP on the thyroid system in female goldfish are remain unclear. In the present study, plasma thyroid hormone (TH) and thyr...
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| description | Our recent study showed that monocrotophos (MCP) pesticide disrupted the hypothalamic-pituitary-thyroid (HPT) axis in male goldfish (Carassius auratus); however, the effects of MCP on the thyroid system in female goldfish are remain unclear. In the present study, plasma thyroid hormone (TH) and thyroid-stimulating hormone (TSH) levels were evaluated in female goldfish exposed to 0.01, 0.10, and 1.00 mg/L of 40% MCP-based pesticide for 21 days in a semi-static exposure system. Expression profiles of HPT axis-responsive genes, including transthyretin (ttr), deiodinases (d1, d2, and d3), tshβ, thyrotropin-releasing hormone (trh), and corticotrophin-releasing hormone (crh), were determined. The results indicated that MCP decreased the plasma levels of total 3,3',5-triiodo-l-thyronine (TT3) and the ratio of TT3 to total 3,3',5,5'-l-thyroxine (TT4), and induced alternative expression of TH-related genes. Exposure to 0.01 and 0.10 mg/L MCP pesticide resulted in the up-regulation of ttr mRNA. The reduction of plasma TT3 levels was partly attributed to an increase in the metabolism of T3 in the liver, as revealed by the highly elevated hepatic d1 and d3 mRNA levels in the MCP treatment groups, and the expression of hepatic d3 showed a negative correlation with the plasma TT3/TT4 levels in females. Moreover, the plasma TSH levels were lower in females exposed to 0.01 and 0.10 mg/L MCP pesticide, whereas the up-regulation of tshβ mRNA levels was compensated by the decreased plasma TT3 levels. These results indicated that MCP had the potential to influence several pathways of HPT axis homeostasis in female goldfish. |
| doi_str_mv | 10.1371/journal.pone.0108972 |
| format | Article |
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In the present study, plasma thyroid hormone (TH) and thyroid-stimulating hormone (TSH) levels were evaluated in female goldfish exposed to 0.01, 0.10, and 1.00 mg/L of 40% MCP-based pesticide for 21 days in a semi-static exposure system. Expression profiles of HPT axis-responsive genes, including transthyretin (ttr), deiodinases (d1, d2, and d3), tshβ, thyrotropin-releasing hormone (trh), and corticotrophin-releasing hormone (crh), were determined. The results indicated that MCP decreased the plasma levels of total 3,3',5-triiodo-l-thyronine (TT3) and the ratio of TT3 to total 3,3',5,5'-l-thyroxine (TT4), and induced alternative expression of TH-related genes. Exposure to 0.01 and 0.10 mg/L MCP pesticide resulted in the up-regulation of ttr mRNA. The reduction of plasma TT3 levels was partly attributed to an increase in the metabolism of T3 in the liver, as revealed by the highly elevated hepatic d1 and d3 mRNA levels in the MCP treatment groups, and the expression of hepatic d3 showed a negative correlation with the plasma TT3/TT4 levels in females. Moreover, the plasma TSH levels were lower in females exposed to 0.01 and 0.10 mg/L MCP pesticide, whereas the up-regulation of tshβ mRNA levels was compensated by the decreased plasma TT3 levels. These results indicated that MCP had the potential to influence several pathways of HPT axis homeostasis in female goldfish.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0108972</identifier><identifier>PMID: 25268935</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Agrochemicals ; Animals ; Biology and Life Sciences ; Brain - metabolism ; Carassius auratus ; Corticotropin-releasing hormone ; Corticotropin-Releasing Hormone - genetics ; Corticotropin-Releasing Hormone - metabolism ; Drinking water ; Ecology and Environmental Sciences ; Endocrine system ; Exposure ; Female ; Females ; Fish ; Gender differences ; Gene expression ; Genes ; Genetic aspects ; Goldfish - metabolism ; Homeostasis ; Hormones ; Hypothalamic-pituitary-thyroid axis ; Hypothalamus ; Iodide Peroxidase - genetics ; Iodide Peroxidase - metabolism ; Kidney - metabolism ; Life sciences ; Liver ; Liver - metabolism ; Metabolism ; Monocrotophos ; Monocrotophos - toxicity ; mRNA ; Neurohormones ; Pesticides ; Pesticides - toxicity ; Pituitary ; Plasma ; Plasma levels ; Prealbumin - genetics ; Prealbumin - metabolism ; RNA ; RNA, Messenger - metabolism ; Stress response ; Thyroid ; Thyroid gland ; Thyroid Gland - metabolism ; Thyroid Hormones - blood ; Thyroid-stimulating hormone ; Thyrotropin ; Thyrotropin - blood ; Thyrotropin-releasing hormone ; Thyrotropin-Releasing Hormone - genetics ; Thyrotropin-Releasing Hormone - metabolism ; Thyroxine ; Thyroxine - blood ; Transthyretin ; Triiodothyronine ; Triiodothyronine - blood ; Zebrafish</subject><ispartof>PloS one, 2014-09, Vol.9 (9), p.e108972</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Zhang et al 2014 Zhang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-63a21e44f23e7c5f036bdeba77cf85212803b14a8c60fa25a47fafd71b31ce593</citedby><cites>FETCH-LOGICAL-c692t-63a21e44f23e7c5f036bdeba77cf85212803b14a8c60fa25a47fafd71b31ce593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182569/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182569/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23868,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25268935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Laudet, Vincent</contributor><creatorcontrib>Zhang, Xiaona</creatorcontrib><creatorcontrib>Tian, Hua</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Ru, Shaoguo</creatorcontrib><title>Monocrotophos pesticide decreases the plasma levels of total 3,3',5-triiodo-l-thyronine and alters the expression of genes associated with the thyroidal axis in female goldfish (Carassius auratus)</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Our recent study showed that monocrotophos (MCP) pesticide disrupted the hypothalamic-pituitary-thyroid (HPT) axis in male goldfish (Carassius auratus); however, the effects of MCP on the thyroid system in female goldfish are remain unclear. In the present study, plasma thyroid hormone (TH) and thyroid-stimulating hormone (TSH) levels were evaluated in female goldfish exposed to 0.01, 0.10, and 1.00 mg/L of 40% MCP-based pesticide for 21 days in a semi-static exposure system. Expression profiles of HPT axis-responsive genes, including transthyretin (ttr), deiodinases (d1, d2, and d3), tshβ, thyrotropin-releasing hormone (trh), and corticotrophin-releasing hormone (crh), were determined. The results indicated that MCP decreased the plasma levels of total 3,3',5-triiodo-l-thyronine (TT3) and the ratio of TT3 to total 3,3',5,5'-l-thyroxine (TT4), and induced alternative expression of TH-related genes. Exposure to 0.01 and 0.10 mg/L MCP pesticide resulted in the up-regulation of ttr mRNA. The reduction of plasma TT3 levels was partly attributed to an increase in the metabolism of T3 in the liver, as revealed by the highly elevated hepatic d1 and d3 mRNA levels in the MCP treatment groups, and the expression of hepatic d3 showed a negative correlation with the plasma TT3/TT4 levels in females. Moreover, the plasma TSH levels were lower in females exposed to 0.01 and 0.10 mg/L MCP pesticide, whereas the up-regulation of tshβ mRNA levels was compensated by the decreased plasma TT3 levels. These results indicated that MCP had the potential to influence several pathways of HPT axis homeostasis in female goldfish.</description><subject>Agrochemicals</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Brain - metabolism</subject><subject>Carassius auratus</subject><subject>Corticotropin-releasing hormone</subject><subject>Corticotropin-Releasing Hormone - genetics</subject><subject>Corticotropin-Releasing Hormone - metabolism</subject><subject>Drinking water</subject><subject>Ecology and Environmental Sciences</subject><subject>Endocrine system</subject><subject>Exposure</subject><subject>Female</subject><subject>Females</subject><subject>Fish</subject><subject>Gender differences</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Goldfish - metabolism</subject><subject>Homeostasis</subject><subject>Hormones</subject><subject>Hypothalamic-pituitary-thyroid axis</subject><subject>Hypothalamus</subject><subject>Iodide Peroxidase - genetics</subject><subject>Iodide Peroxidase - metabolism</subject><subject>Kidney - metabolism</subject><subject>Life sciences</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Metabolism</subject><subject>Monocrotophos</subject><subject>Monocrotophos - toxicity</subject><subject>mRNA</subject><subject>Neurohormones</subject><subject>Pesticides</subject><subject>Pesticides - toxicity</subject><subject>Pituitary</subject><subject>Plasma</subject><subject>Plasma levels</subject><subject>Prealbumin - genetics</subject><subject>Prealbumin - metabolism</subject><subject>RNA</subject><subject>RNA, Messenger - metabolism</subject><subject>Stress response</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid Hormones - blood</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyrotropin</subject><subject>Thyrotropin - blood</subject><subject>Thyrotropin-releasing hormone</subject><subject>Thyrotropin-Releasing Hormone - genetics</subject><subject>Thyrotropin-Releasing Hormone - metabolism</subject><subject>Thyroxine</subject><subject>Thyroxine - blood</subject><subject>Transthyretin</subject><subject>Triiodothyronine</subject><subject>Triiodothyronine - blood</subject><subject>Zebrafish</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tq3DAQhk1padK0b1BaQaFNIN5akm3ZN4UQegikBHq6FbPyaK2gtRxJTpP364NVm92EbMlF0YWF_P3_SHPIspe0mFEu6PtzN_kB7Gx0A84KWjStYI-yXdpyltes4I_v7XeyZyGcF0XFm7p-mu2witVNy6vd7M9XNzjlXXRj7wIZMUSjTIekQ-URAgYSeySjhbAEYvESbSBOk-giWMIP-bvDKo_eGNe53Oaxv_ZuMAMSGDoCNqJfG-DV6DEE44aVeoFDMoYQnDIQsSO_TexvuBsD0yVvuDKBmIFoXIJFsnC20yb0ZP8YfFKaKRlMHuIUDp5nTzTYgC82373s56ePP46_5Kdnn0-Oj05zVbcs5jUHRrEsNeMoVKULXs87nIMQSjcVo6wp-JyW0Ki60MAqKIUG3Qk651Rh1fK97PXad7QuyE0BgqStaBsqBG8ScbImOgfncvRmCf5aOjDy5sD5hQSfMmxRlinAXEPDhNZlU9YgVM26imNRI6CaJ68Pm2jTfImdwiF6sFum238G08uFu5QlbVhVr667vzHw7mJKlZVLExRaCwO6Kd27qkVRsYqyhL75B334dRtqkSoizaBdiqtWpvKopIKWZdOsqNkDVFodLo1K3apNOt8SHGwJEhPxKi5gCkGefP_2_-zZr2327T22x9SOfXB2iqkLwzZYrsE0CCF41HdJpoVcDdttNuRq2ORm2JLs1f0C3Ylup4v_BfSMKRk</recordid><startdate>20140930</startdate><enddate>20140930</enddate><creator>Zhang, Xiaona</creator><creator>Tian, Hua</creator><creator>Wang, Wei</creator><creator>Ru, Shaoguo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140930</creationdate><title>Monocrotophos pesticide decreases the plasma levels of total 3,3',5-triiodo-l-thyronine and alters the expression of genes associated with the thyroidal axis in female goldfish (Carassius auratus)</title><author>Zhang, Xiaona ; Tian, Hua ; Wang, Wei ; Ru, Shaoguo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-63a21e44f23e7c5f036bdeba77cf85212803b14a8c60fa25a47fafd71b31ce593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Agrochemicals</topic><topic>Animals</topic><topic>Biology and Life Sciences</topic><topic>Brain - metabolism</topic><topic>Carassius auratus</topic><topic>Corticotropin-releasing hormone</topic><topic>Corticotropin-Releasing Hormone - genetics</topic><topic>Corticotropin-Releasing Hormone - metabolism</topic><topic>Drinking water</topic><topic>Ecology and Environmental Sciences</topic><topic>Endocrine system</topic><topic>Exposure</topic><topic>Female</topic><topic>Females</topic><topic>Fish</topic><topic>Gender differences</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Goldfish - metabolism</topic><topic>Homeostasis</topic><topic>Hormones</topic><topic>Hypothalamic-pituitary-thyroid axis</topic><topic>Hypothalamus</topic><topic>Iodide Peroxidase - genetics</topic><topic>Iodide Peroxidase - metabolism</topic><topic>Kidney - metabolism</topic><topic>Life sciences</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Metabolism</topic><topic>Monocrotophos</topic><topic>Monocrotophos - toxicity</topic><topic>mRNA</topic><topic>Neurohormones</topic><topic>Pesticides</topic><topic>Pesticides - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xiaona</au><au>Tian, Hua</au><au>Wang, Wei</au><au>Ru, Shaoguo</au><au>Laudet, Vincent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monocrotophos pesticide decreases the plasma levels of total 3,3',5-triiodo-l-thyronine and alters the expression of genes associated with the thyroidal axis in female goldfish (Carassius auratus)</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-09-30</date><risdate>2014</risdate><volume>9</volume><issue>9</issue><spage>e108972</spage><pages>e108972-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Our recent study showed that monocrotophos (MCP) pesticide disrupted the hypothalamic-pituitary-thyroid (HPT) axis in male goldfish (Carassius auratus); however, the effects of MCP on the thyroid system in female goldfish are remain unclear. In the present study, plasma thyroid hormone (TH) and thyroid-stimulating hormone (TSH) levels were evaluated in female goldfish exposed to 0.01, 0.10, and 1.00 mg/L of 40% MCP-based pesticide for 21 days in a semi-static exposure system. Expression profiles of HPT axis-responsive genes, including transthyretin (ttr), deiodinases (d1, d2, and d3), tshβ, thyrotropin-releasing hormone (trh), and corticotrophin-releasing hormone (crh), were determined. The results indicated that MCP decreased the plasma levels of total 3,3',5-triiodo-l-thyronine (TT3) and the ratio of TT3 to total 3,3',5,5'-l-thyroxine (TT4), and induced alternative expression of TH-related genes. Exposure to 0.01 and 0.10 mg/L MCP pesticide resulted in the up-regulation of ttr mRNA. The reduction of plasma TT3 levels was partly attributed to an increase in the metabolism of T3 in the liver, as revealed by the highly elevated hepatic d1 and d3 mRNA levels in the MCP treatment groups, and the expression of hepatic d3 showed a negative correlation with the plasma TT3/TT4 levels in females. Moreover, the plasma TSH levels were lower in females exposed to 0.01 and 0.10 mg/L MCP pesticide, whereas the up-regulation of tshβ mRNA levels was compensated by the decreased plasma TT3 levels. These results indicated that MCP had the potential to influence several pathways of HPT axis homeostasis in female goldfish.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25268935</pmid><doi>10.1371/journal.pone.0108972</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-09, Vol.9 (9), p.e108972 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1979817738 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Agrochemicals Animals Biology and Life Sciences Brain - metabolism Carassius auratus Corticotropin-releasing hormone Corticotropin-Releasing Hormone - genetics Corticotropin-Releasing Hormone - metabolism Drinking water Ecology and Environmental Sciences Endocrine system Exposure Female Females Fish Gender differences Gene expression Genes Genetic aspects Goldfish - metabolism Homeostasis Hormones Hypothalamic-pituitary-thyroid axis Hypothalamus Iodide Peroxidase - genetics Iodide Peroxidase - metabolism Kidney - metabolism Life sciences Liver Liver - metabolism Metabolism Monocrotophos Monocrotophos - toxicity mRNA Neurohormones Pesticides Pesticides - toxicity Pituitary Plasma Plasma levels Prealbumin - genetics Prealbumin - metabolism RNA RNA, Messenger - metabolism Stress response Thyroid Thyroid gland Thyroid Gland - metabolism Thyroid Hormones - blood Thyroid-stimulating hormone Thyrotropin Thyrotropin - blood Thyrotropin-releasing hormone Thyrotropin-Releasing Hormone - genetics Thyrotropin-Releasing Hormone - metabolism Thyroxine Thyroxine - blood Transthyretin Triiodothyronine Triiodothyronine - blood Zebrafish |
| title | Monocrotophos pesticide decreases the plasma levels of total 3,3',5-triiodo-l-thyronine and alters the expression of genes associated with the thyroidal axis in female goldfish (Carassius auratus) |
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