Human cytomegalovirus tegument protein pp65 is detected in all intra- and extra-axial brain tumours independent of the tumour type or grade

Human cytomegalovirus (HCMV) has been indicated being a significant oncomodulator. Recent reports have suggested that an antiviral treatment alters the outcome of a glioblastoma. We analysed the performance of commercial HCMV-antibodies applying the immunohistochemical (IHC) methods on brain sample...

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Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e108861-e108861
Hauptverfasser:	Libard, Sylwia, Popova, Svetlana N, Amini, Rose-Marie, Kärjä, Vesa, Pietiläinen, Timo, Hämäläinen, Kirsi M, Sundström, Christer, Hesselager, Göran, Bergqvist, Michael, Ekman, Simon, Zetterling, Maria, Smits, Anja, Nilsson, Pelle, Pfeifer, Susan, de Ståhl, Teresita Diaz, Enblad, Gunilla, Ponten, Fredrik, Alafuzoff, Irina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antibodies Antigens Antiviral agents B-cell lymphoma Biology and Life Sciences Brain Brain cancer Brain Neoplasms - pathology Brain Neoplasms - virology Brain research Brain tumors Clinical trials Cloning Cohort Studies Cores Cytomegalovirus Cytomegalovirus - isolation & purification Cytomegalovirus - metabolism Cytomegalovirus infections Degeneration Deoxyribonucleic acid DNA Female Glioblastoma Glioblastoma - pathology Glioblastoma - virology Glioma Gliomas Health aspects Humans Immunohistochemistry Immunology Immunoreactivity Infection Infections Labeling Labelling Lymphocytes B Lymphoma Lymphoma - pathology Lymphoma - virology Lymphomas Male Medical prognosis Medicin och hälsovetenskap Medicine and Health Sciences Medulloblastoma - pathology Medulloblastoma - virology Meningioma - pathology Meningioma - virology Middle Aged Neoplasm Grading Neurodegeneration Neurosurgery Oncology Pathology Patologi Phosphoproteins - analysis Pp65 protein Protein expression Proteins R&D Research & development Sampling methods Tegument Telomerase Tumors Viral Matrix Proteins - analysis Viruses Young Adult
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