Phospholipase cε, an effector of ras and rap small GTPases, is required for airway inflammatory response in a mouse model of bronchial asthma

Phospholipase Cε (PLCε) is an effector of Ras and Rap small GTPases and expressed in non-immune cells. It is well established that PLCε plays an important role in skin inflammation, such as that elicited by phorbol ester painting or ultraviolet irradiation and contact dermatitis that is mediated by...

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Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e108373
Hauptverfasser:	Nagano, Tatsuya, Edamatsu, Hironori, Kobayashi, Kazuyuki, Takenaka, Nobuyuki, Yamamoto, Masatsugu, Sasaki, Naoto, Nishimura, Yoshihiro, Kataoka, Tohru
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Alveoli Animals Asthma Asthma - chemically induced Asthma - enzymology Asthma - immunology Asthma - pathology Biochemistry Biology and Life Sciences Bronchi - enzymology Bronchi - immunology Bronchi - pathology Bronchial Hyperreactivity - chemically induced Bronchial Hyperreactivity - enzymology Bronchial Hyperreactivity - immunology Bronchial Hyperreactivity - pathology Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Bronchus Chemokines Computational fluid dynamics Contact dermatitis Cytokines Dermatitis Epithelial cells Epithelial Cells - drug effects Epithelial Cells - enzymology Epithelial Cells - immunology Epithelial Cells - pathology Female Fibroblasts Gene Expression Regulation Genotypes Growth factors Helper cells Immune system Immunization Immunoglobulin E Immunoglobulin E - blood Immunoglobulin G - blood Immunoglobulins Inflammation Inflammatory response Internal medicine Irradiation Keratinocytes Kinases Ligands Lymphocytes T Male Medicine Mice Mice, Knockout Molecular biology Ovalbumin Pathogenesis Phosphoinositide Phospholipase C - deficiency Phosphoinositide Phospholipase C - genetics Phosphoinositide Phospholipase C - immunology Phospholipase Phospholipase C Primary Cell Culture Proteins rap GTP-Binding Proteins - genetics rap GTP-Binding Proteins - immunology ras GTPase-Activating Proteins - genetics ras GTPase-Activating Proteins - immunology Respiratory Mucosa - enzymology Respiratory Mucosa - immunology Respiratory Mucosa - pathology Respiratory system Respiratory tract Respiratory tract diseases Rodents Serum levels Signal Transduction Skin Th1-Th2 Balance - drug effects Th2 Cells - drug effects Th2 Cells - metabolism Th2 Cells - pathology Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-TNF Tumor necrosis factor-α Ultraviolet radiation University graduates
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