Time course of adiponectin and its relationship to psychological aspects in patients with anorexia nervosa during inpatient treatment
The protein hormone adiponectin promotes metabolic and psychological health. The aim of the study was to track changes in adiponectin levels in response to weight gain and to assess associations between adiponectin and psychological aspects in patients with anorexia nervosa (AN). To investigate if a...
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| description | The protein hormone adiponectin promotes metabolic and psychological health. The aim of the study was to track changes in adiponectin levels in response to weight gain and to assess associations between adiponectin and psychological aspects in patients with anorexia nervosa (AN).
To investigate if adiponectin levels depend on AN severity, data were assessed from 11 inpatients with a very low body mass index (BMI) and a high chronicity (high severity group; HSS), and nine with less severe symptoms (LSS). During the course of treatment, serum adiponectin concentrations were assessed on a weekly basis along with BMI. Psychological variables (i.e., depression, anxiety, stress, and AN-specific symptoms) were obtained by means of electronic diaries. Longitudinal regressions and correlations were calculated to evaluate the temporal course of adiponectin and its relationship with psychological self-ratings.
At the beginning adiponectin was not increased in HSS patients (p = .56), and only marginally elevated in LSS patients (p = 0.07) compared with controls. In HSS patients, adiponectin increased along with BMI during the first treatment phase (i.e., when the BMI of patients was below 16 kg/m2) and thereafter decreased with further weight gain. In LSS patients, adiponectin was not associated with BMI increase. Furthermore, adiponectin was strongly negatively correlated with psychological self-ratings when the BMI of patients was above 16 kg/m2, i.e., higher levels of adiponectin were related to lower ratings of depression, anxiety, and AN-specific symptoms.
The study connects previous varying results by indicating that the course of adiponectin is dependent on BMI and symptom severity. Similarly, associations of adiponectin and psychological health depended on BMI. |
| doi_str_mv | 10.1371/journal.pone.0189500 |
| format | Article |
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To investigate if adiponectin levels depend on AN severity, data were assessed from 11 inpatients with a very low body mass index (BMI) and a high chronicity (high severity group; HSS), and nine with less severe symptoms (LSS). During the course of treatment, serum adiponectin concentrations were assessed on a weekly basis along with BMI. Psychological variables (i.e., depression, anxiety, stress, and AN-specific symptoms) were obtained by means of electronic diaries. Longitudinal regressions and correlations were calculated to evaluate the temporal course of adiponectin and its relationship with psychological self-ratings.
At the beginning adiponectin was not increased in HSS patients (p = .56), and only marginally elevated in LSS patients (p = 0.07) compared with controls. In HSS patients, adiponectin increased along with BMI during the first treatment phase (i.e., when the BMI of patients was below 16 kg/m2) and thereafter decreased with further weight gain. In LSS patients, adiponectin was not associated with BMI increase. Furthermore, adiponectin was strongly negatively correlated with psychological self-ratings when the BMI of patients was above 16 kg/m2, i.e., higher levels of adiponectin were related to lower ratings of depression, anxiety, and AN-specific symptoms.
The study connects previous varying results by indicating that the course of adiponectin is dependent on BMI and symptom severity. Similarly, associations of adiponectin and psychological health depended on BMI.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0189500</identifier><identifier>PMID: 29261731</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adipocytes ; Adiponectin ; Anorexia ; Anorexia nervosa ; Antidepressants ; Anxiety ; Biology and Life Sciences ; Body mass ; Body mass index ; Body size ; Body weight gain ; Care and treatment ; Diaries ; Eating disorders ; Health aspects ; Hospital patients ; Hospitals ; Illnesses ; Internal medicine ; Medicine ; Medicine and Health Sciences ; Mental depression ; Patients ; Peptides ; Physiological aspects ; Protein hormones ; Psychological aspects ; Psychological factors ; Psychosomatic medicine ; Psychotherapy ; Ratings ; Social Sciences ; Studies ; Weight control ; Weight gain</subject><ispartof>PloS one, 2017-12, Vol.12 (12), p.e0189500-e0189500</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Buckert et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Buckert et al 2017 Buckert et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-216b7fc55427215aaea4dc03b7cfd85331f04997a809d24401ebab67796c10553</citedby><cites>FETCH-LOGICAL-c692t-216b7fc55427215aaea4dc03b7cfd85331f04997a809d24401ebab67796c10553</cites><orcidid>0000-0002-6126-0442</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738020/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738020/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29261731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Stengel, Andreas</contributor><creatorcontrib>Buckert, Magdalena</creatorcontrib><creatorcontrib>Stroe-Kunold, Esther</creatorcontrib><creatorcontrib>Friederich, Hans-Christoph</creatorcontrib><creatorcontrib>Wesche, Daniela</creatorcontrib><creatorcontrib>Walter, Christiane</creatorcontrib><creatorcontrib>Kopf, Stefan</creatorcontrib><creatorcontrib>Simon, Joe J</creatorcontrib><creatorcontrib>Herzog, Wolfgang</creatorcontrib><creatorcontrib>Wild, Beate</creatorcontrib><title>Time course of adiponectin and its relationship to psychological aspects in patients with anorexia nervosa during inpatient treatment</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The protein hormone adiponectin promotes metabolic and psychological health. The aim of the study was to track changes in adiponectin levels in response to weight gain and to assess associations between adiponectin and psychological aspects in patients with anorexia nervosa (AN).
To investigate if adiponectin levels depend on AN severity, data were assessed from 11 inpatients with a very low body mass index (BMI) and a high chronicity (high severity group; HSS), and nine with less severe symptoms (LSS). During the course of treatment, serum adiponectin concentrations were assessed on a weekly basis along with BMI. Psychological variables (i.e., depression, anxiety, stress, and AN-specific symptoms) were obtained by means of electronic diaries. Longitudinal regressions and correlations were calculated to evaluate the temporal course of adiponectin and its relationship with psychological self-ratings.
At the beginning adiponectin was not increased in HSS patients (p = .56), and only marginally elevated in LSS patients (p = 0.07) compared with controls. In HSS patients, adiponectin increased along with BMI during the first treatment phase (i.e., when the BMI of patients was below 16 kg/m2) and thereafter decreased with further weight gain. In LSS patients, adiponectin was not associated with BMI increase. Furthermore, adiponectin was strongly negatively correlated with psychological self-ratings when the BMI of patients was above 16 kg/m2, i.e., higher levels of adiponectin were related to lower ratings of depression, anxiety, and AN-specific symptoms.
The study connects previous varying results by indicating that the course of adiponectin is dependent on BMI and symptom severity. Similarly, associations of adiponectin and psychological health depended on BMI.</description><subject>Adipocytes</subject><subject>Adiponectin</subject><subject>Anorexia</subject><subject>Anorexia nervosa</subject><subject>Antidepressants</subject><subject>Anxiety</subject><subject>Biology and Life Sciences</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Body weight gain</subject><subject>Care and treatment</subject><subject>Diaries</subject><subject>Eating disorders</subject><subject>Health aspects</subject><subject>Hospital patients</subject><subject>Hospitals</subject><subject>Illnesses</subject><subject>Internal medicine</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Mental depression</subject><subject>Patients</subject><subject>Peptides</subject><subject>Physiological aspects</subject><subject>Protein hormones</subject><subject>Psychological 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course of adiponectin and its relationship to psychological aspects in patients with anorexia nervosa during inpatient treatment</title><author>Buckert, Magdalena ; Stroe-Kunold, Esther ; Friederich, Hans-Christoph ; Wesche, Daniela ; Walter, Christiane ; Kopf, Stefan ; Simon, Joe J ; Herzog, Wolfgang ; Wild, Beate</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-216b7fc55427215aaea4dc03b7cfd85331f04997a809d24401ebab67796c10553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adipocytes</topic><topic>Adiponectin</topic><topic>Anorexia</topic><topic>Anorexia nervosa</topic><topic>Antidepressants</topic><topic>Anxiety</topic><topic>Biology and Life Sciences</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Body weight gain</topic><topic>Care and treatment</topic><topic>Diaries</topic><topic>Eating disorders</topic><topic>Health 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Christiane</au><au>Kopf, Stefan</au><au>Simon, Joe J</au><au>Herzog, Wolfgang</au><au>Wild, Beate</au><au>Stengel, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Time course of adiponectin and its relationship to psychological aspects in patients with anorexia nervosa during inpatient treatment</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-12-20</date><risdate>2017</risdate><volume>12</volume><issue>12</issue><spage>e0189500</spage><epage>e0189500</epage><pages>e0189500-e0189500</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The protein hormone adiponectin promotes metabolic and psychological health. The aim of the study was to track changes in adiponectin levels in response to weight gain and to assess associations between adiponectin and psychological aspects in patients with anorexia nervosa (AN).
To investigate if adiponectin levels depend on AN severity, data were assessed from 11 inpatients with a very low body mass index (BMI) and a high chronicity (high severity group; HSS), and nine with less severe symptoms (LSS). During the course of treatment, serum adiponectin concentrations were assessed on a weekly basis along with BMI. Psychological variables (i.e., depression, anxiety, stress, and AN-specific symptoms) were obtained by means of electronic diaries. Longitudinal regressions and correlations were calculated to evaluate the temporal course of adiponectin and its relationship with psychological self-ratings.
At the beginning adiponectin was not increased in HSS patients (p = .56), and only marginally elevated in LSS patients (p = 0.07) compared with controls. In HSS patients, adiponectin increased along with BMI during the first treatment phase (i.e., when the BMI of patients was below 16 kg/m2) and thereafter decreased with further weight gain. In LSS patients, adiponectin was not associated with BMI increase. Furthermore, adiponectin was strongly negatively correlated with psychological self-ratings when the BMI of patients was above 16 kg/m2, i.e., higher levels of adiponectin were related to lower ratings of depression, anxiety, and AN-specific symptoms.
The study connects previous varying results by indicating that the course of adiponectin is dependent on BMI and symptom severity. Similarly, associations of adiponectin and psychological health depended on BMI.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29261731</pmid><doi>10.1371/journal.pone.0189500</doi><orcidid>https://orcid.org/0000-0002-6126-0442</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2017-12, Vol.12 (12), p.e0189500-e0189500 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1979768410 |
| source | Full-Text Journals in Chemistry (Open access); Directory of Open Access Journals; Public Library of Science; PubMed Central; EZB Electronic Journals Library |
| subjects | Adipocytes Adiponectin Anorexia Anorexia nervosa Antidepressants Anxiety Biology and Life Sciences Body mass Body mass index Body size Body weight gain Care and treatment Diaries Eating disorders Health aspects Hospital patients Hospitals Illnesses Internal medicine Medicine Medicine and Health Sciences Mental depression Patients Peptides Physiological aspects Protein hormones Psychological aspects Psychological factors Psychosomatic medicine Psychotherapy Ratings Social Sciences Studies Weight control Weight gain |
| title | Time course of adiponectin and its relationship to psychological aspects in patients with anorexia nervosa during inpatient treatment |
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