An examination of the relationship between hotspots and recombination associated with chromosome 21 nondisjunction

Trisomy 21, resulting in Down Syndrome (DS), is the most common autosomal trisomy among live-born infants and is caused mainly by nondisjunction of chromosome 21 within oocytes. Risk factors for nondisjunction depend on the parental origin and type of meiotic error. For errors in the oocyte, increas...

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e99560
Hauptverfasser:	Oliver, Tiffany Renee, Middlebrooks, Candace D, Tinker, Stuart W, Allen, Emily Graves, Bean, Lora J H, Begum, Ferdouse, Feingold, Eleanor, Chowdhury, Reshmi, Cheung, Vivian, Sherman, Stephanie L
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Biology and life sciences Chromosome 21 Chromosomes Chromosomes, Human, Pair 21 - genetics CpG islands Down syndrome Down Syndrome - genetics Down's syndrome Female Genetic aspects Genetic recombination Genomes Genomics Genotype Hot spots Humans Infants Male Medicine Medicine and Health Sciences Meiosis Nondisjunction Nondisjunction, Genetic Oocytes Oral hygiene Placement Polyadenine Public health Recombination Recombination, Genetic Risk analysis Risk Factors Statistical analysis Studies Trisomy
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