Pharmacological preconditioning with vitamin C attenuates intestinal injury via the induction of heme oxygenase-1 after hemorrhagic shock in rats

Pre-induction of heme oxygenase (HO)-1, which is regarded as an effective method of "organ preconditioning", exerts beneficial effects during hemorrhagic shock (HS). However, the available HO-1 inducers exhibit disadvantages such as toxicity or complex technical requirements. Therefore, a...

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e99134
Hauptverfasser:	Zhao, Bing, Fei, Jian, Chen, Ying, Ying, Yi-Lin, Ma, Li, Song, Xiao-Qin, Wang, Lu, Chen, Er-Zhen, Mao, En-Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - administration & dosage Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Ascorbic acid Ascorbic Acid - administration & dosage Ascorbic Acid - pharmacology Biocompatibility Biology and Life Sciences Carbon monoxide Cells, Cultured Disease Models, Animal Epithelial cells Extracellular signal-regulated kinase Gene Expression Regulation - drug effects Growth factors Heat shock proteins Heme Heme oxygenase (decyclizing) Heme Oxygenase-1 - metabolism Hemorrhage Hemorrhagic shock In vivo methods and tests Infiltration Inflammation Injuries Injury prevention Intensive care Interleukin 6 Intestinal Diseases - enzymology Intestinal Diseases - prevention & control Intestine Intestines - drug effects Intestines - enzymology Intestines - injuries Ischemia Kinases Laboratory animals MAP Kinase Signaling System - drug effects Medicine Medicine and Health Sciences Metastases Neutrophils Oxidative stress Oxygenase Pharmacology Preconditioning Protoporphyrin Rats Rats, Sprague-Dawley Rodents Shock, Hemorrhagic - complications Shock, Hemorrhagic - enzymology Shock, Hemorrhagic - pathology Stem cells Surgery Toxicity Trauma Vitamin C Zinc
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