Bicarbonate buffered peritoneal dialysis fluid upregulates angiopoietin-1 and promotes vessel maturation

Ultrafiltration decline is a progressive issue for patients on chronic peritoneal dialysis (PD) and can be caused by peritoneal angiogenesis induced by PD fluids. A recent pediatric trial suggests better preservation of ultrafiltration with bicarbonate versus lactate buffered fluid; underlying molec...

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Veröffentlicht in:	PloS one 2017-12, Vol.12 (12), p.e0189903-e0189903
Hauptverfasser:	Eich, Gwendolyn, Bartosova, Maria, Tischer, Christian, Wlodkowski, Tanja Tamara, Schaefer, Betti, Pichl, Sebastian, Kraewer, Nicole, Ranchin, Bruno, Vondrak, Karel, Liebau, Max Christoph, Hackert, Thilo, Schmitt, Claus Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Adolescent Angiogenesis Angiopoietin Angiopoietin-1 - metabolism Angiopoietin-2 - metabolism Bicarbonates Bicarbonates - chemistry Biology and Life Sciences Biopsy Blood vessels Buffers Carbonates Child Children Chronic Disease Comparative analysis Cytokines - metabolism Degradation Dialysis Endothelial cells Endothelial Cells - metabolism Endothelium Fluids Glucose Glucose - chemistry Histomorphometry Human Umbilical Vein Endothelial Cells Humans Hydrogen-Ion Concentration Immunohistochemistry Incubation Kidney Diseases - therapy Lactates - chemistry Lactic acid Maturation Medicine Medicine and Health Sciences Microscopy Molecular modelling mRNA Network analysis Pediatrics Peritoneal Dialysis Peritoneum Peritoneum - pathology Peritonitis pH effects Physical Sciences Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Preservation Promoters (Genetics) Protein folding Protein-tyrosine kinase receptors Receptor Protein-Tyrosine Kinases - metabolism Research and Analysis Methods Translocation Tyrosine Ultrafiltration Umbilical vein Vascular endothelial growth factor
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