Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation

It is known that obese adipose tissues are hypoxic and express hypoxia-inducible factor (HIF)-1α. Although some studies have shown that the expression of HIF-1α in adipocytes induces glucose intolerance, the mechanisms are still not clear. In this study, we examined its effects on the development of...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e93856
Hauptverfasser:	Kihira, Yoshitaka, Miyake, Mariko, Hirata, Manami, Hoshina, Yoji, Kato, Kana, Shirakawa, Hitoshi, Sakaue, Hiroshi, Yamano, Noriko, Izawa-Ishizawa, Yuki, Ishizawa, Keisuke, Ikeda, Yasumasa, Tsuchiya, Koichiro, Tamaki, Toshiaki, Tomita, Shuhei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - metabolism Adiponectin Adipose tissue Animal tissues Animals Biology and Life Sciences Blotting, Western Body fat Chemokine CCL2 - metabolism Clonal deletion Diabetes mellitus Diabetes Mellitus, Type 2 - physiopathology DNA Primers - genetics Gene Deletion Glucagon Glucagon-like peptide 1 Glucagon-Like Peptide 1 - metabolism Glucose Glucose tolerance Glucose Tolerance Test High fat diet Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - deficiency Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-inducible factors Immunohistochemistry Infiltration Insulin Insulin - blood Insulin - metabolism Insulin resistance Insulin Secretion Intestine Intolerance Kinases L cells Macrophages Medicine and Health Sciences Metastases Mice Mice, Knockout Monocyte chemoattractant protein 1 mRNA Obesity Real-Time Polymerase Chain Reaction Research and Analysis Methods Rodents Secretion Serum levels Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α
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