Task-specific and general cognitive effects in Chiari malformation type I
Our objective was to use episodic memory and executive function tests to determine whether or not Chiari Malformation Type I (CM) patients experience cognitive dysfunction. CM is a neurological syndrome in which the cerebellum descends into the cervical spine causing neural compression, severe heada...
Gespeichert in:
| Veröffentlicht in: | PloS one 2014-04, Vol.9 (4), p.e94844-e94844 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e94844 |
|---|---|
| container_issue | 4 |
| container_start_page | e94844 |
| container_title | PloS one |
| container_volume | 9 |
| creator | Allen, Philip A Houston, James R Pollock, Joshua W Buzzelli, Christopher Li, Xuan Harrington, A Katherine Martin, Bryn A Loth, Francis Lien, Mei-Ching Maleki, Jahangir Luciano, Mark G |
| description | Our objective was to use episodic memory and executive function tests to determine whether or not Chiari Malformation Type I (CM) patients experience cognitive dysfunction.
CM is a neurological syndrome in which the cerebellum descends into the cervical spine causing neural compression, severe headaches, neck pain, and number of other physical symptoms. While primarily a disorder of the cervico-medullary junction, both clinicians and researchers have suspected deficits in higher-level cognitive function.
We tested 24 CM patients who had undergone decompression neurosurgery and 24 age- and education-matched controls on measures of immediate and delayed episodic memory, as well as three measures of executive function.
The CM group showed performance decrements relative to the controls in response inhibition (Stroop interference), working memory computational speed (Ospan), and processing speed (automated digit symbol substitution task), but group differences in recall did not reach statistical significance. After statistical control for depression and anxiety scores, the group effects for working memory and processing speed were eliminated, but not for response inhibition. This response inhibition difference was not due to overall general slowing for the CM group, either, because when controls' data were transformed using the linear function fit to all of the reaction time tasks, the interaction with group remained statistically significant. Furthermore, there was a multivariate group effect for all of the response time measures and immediate and delayed recall after statistical control of depression and anxiety scores.
These results suggest that CM patients with decompression surgery exhibit cognitive dysfunction compared to age- and education-matched controls. While some of these results may be related to anxiety and depression (likely proxies for chronic pain), response inhibition effects, in particular, as well as a general cognitive deficit persisted even after control for anxiety and decompression. |
| doi_str_mv | 10.1371/journal.pone.0094844 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1977746300</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A375583992</galeid><doaj_id>oai_doaj_org_article_349bafc19363406f9738051a4448414e</doaj_id><sourcerecordid>A375583992</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-4f0abb883cfdde6502600f4972160442393c53edb4866acee13d28df431c9b4e3</originalsourceid><addsrcrecordid>eNqNkl-P1CAUxRujcdfVb2C0iYnRhxmhUAovJpuJfybZZBNdfSWUXjqMbRmBbtxvL7PT3UzNPhgeIPC758LhZNlLjJaYVPjD1o1-UN1y5wZYIiQop_RRdooFKRasQOTx0fokexbCFqGScMaeZicFrQhjFTvN1lcq_FqEHWhrrM7V0OQtDOBVl2vXDjbaa8jBGNAx5HbIVxurvM171RnnexWtG_J4s4N8_Tx7YlQX4MU0n2U_Pn-6Wn1dXFx-Wa_OLxaaiSIuqEGqrjkn2jQNsBIVDCFDRVVghigtiCC6JNDUNF1VaQBMmoI3hhKsRU2BnGWvD7q7zgU5uRAkFlVVUUYQSsT6QDRObeXO2175G-mUlbcbzrdS-Wh1B5JQUSujk1GMUMSMqAhHJVaUJjvxbbePU7ex7qHRMMTkzUx0fjLYjWzdtSSCc8RxEng3CXj3e4QQZW-Dhq5TA7gx3bvEFecFQTShb_5BH37dRLUqPcAOxqW-ei8qz0lVlpwIUSRq-QCVRgO91Skyxqb9WcH7WUFiIvyJrRpDkOvv3_6fvfw5Z98esRtQXdwE14375IQ5SA-g9i4ED-beZIzkPvF3bsh94uWU-FT26viD7ovuIk7-Aiev-Wo</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1977746300</pqid></control><display><type>article</type><title>Task-specific and general cognitive effects in Chiari malformation type I</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Allen, Philip A ; Houston, James R ; Pollock, Joshua W ; Buzzelli, Christopher ; Li, Xuan ; Harrington, A Katherine ; Martin, Bryn A ; Loth, Francis ; Lien, Mei-Ching ; Maleki, Jahangir ; Luciano, Mark G</creator><contributor>Sutherland, Robert</contributor><creatorcontrib>Allen, Philip A ; Houston, James R ; Pollock, Joshua W ; Buzzelli, Christopher ; Li, Xuan ; Harrington, A Katherine ; Martin, Bryn A ; Loth, Francis ; Lien, Mei-Ching ; Maleki, Jahangir ; Luciano, Mark G ; Sutherland, Robert</creatorcontrib><description>Our objective was to use episodic memory and executive function tests to determine whether or not Chiari Malformation Type I (CM) patients experience cognitive dysfunction.
CM is a neurological syndrome in which the cerebellum descends into the cervical spine causing neural compression, severe headaches, neck pain, and number of other physical symptoms. While primarily a disorder of the cervico-medullary junction, both clinicians and researchers have suspected deficits in higher-level cognitive function.
We tested 24 CM patients who had undergone decompression neurosurgery and 24 age- and education-matched controls on measures of immediate and delayed episodic memory, as well as three measures of executive function.
The CM group showed performance decrements relative to the controls in response inhibition (Stroop interference), working memory computational speed (Ospan), and processing speed (automated digit symbol substitution task), but group differences in recall did not reach statistical significance. After statistical control for depression and anxiety scores, the group effects for working memory and processing speed were eliminated, but not for response inhibition. This response inhibition difference was not due to overall general slowing for the CM group, either, because when controls' data were transformed using the linear function fit to all of the reaction time tasks, the interaction with group remained statistically significant. Furthermore, there was a multivariate group effect for all of the response time measures and immediate and delayed recall after statistical control of depression and anxiety scores.
These results suggest that CM patients with decompression surgery exhibit cognitive dysfunction compared to age- and education-matched controls. While some of these results may be related to anxiety and depression (likely proxies for chronic pain), response inhibition effects, in particular, as well as a general cognitive deficit persisted even after control for anxiety and decompression.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0094844</identifier><identifier>PMID: 24736676</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Age differences ; Aging ; Anxiety ; Arnold-Chiari Malformation - physiopathology ; Biology and Life Sciences ; Brain ; Brain research ; Care and treatment ; Cerebellum ; Chronic pain ; Cognition ; Cognitive ability ; Compression ; Computational neuroscience ; Computer memory ; Congenital defects ; Decompression ; Depression, Mental ; Diagnosis ; Education ; Executive function ; Executive Function - physiology ; Female ; Group effects ; Headache ; Humans ; Inhibition ; Inhibition (psychology) ; Linear functions ; Male ; Mechanical engineering ; Medical imaging ; Medicine and Health Sciences ; Memory ; Memory, Episodic ; Mental depression ; Middle Aged ; Neck ; Neural tube defects ; Neurosurgery ; Pain ; Patients ; Psychology ; Reaction time ; Reaction Time - physiology ; Reaction time task ; Recall ; Response time ; Risk factors ; Short term memory ; Social Sciences ; Spine ; Spine (cervical) ; Statistical analysis ; Statistical significance ; Statistics ; Stroop Test ; Substitution reactions ; Surgery ; Young Adult</subject><ispartof>PloS one, 2014-04, Vol.9 (4), p.e94844-e94844</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Allen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Allen et al 2014 Allen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4f0abb883cfdde6502600f4972160442393c53edb4866acee13d28df431c9b4e3</citedby><cites>FETCH-LOGICAL-c692t-4f0abb883cfdde6502600f4972160442393c53edb4866acee13d28df431c9b4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988081/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988081/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24736676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Sutherland, Robert</contributor><creatorcontrib>Allen, Philip A</creatorcontrib><creatorcontrib>Houston, James R</creatorcontrib><creatorcontrib>Pollock, Joshua W</creatorcontrib><creatorcontrib>Buzzelli, Christopher</creatorcontrib><creatorcontrib>Li, Xuan</creatorcontrib><creatorcontrib>Harrington, A Katherine</creatorcontrib><creatorcontrib>Martin, Bryn A</creatorcontrib><creatorcontrib>Loth, Francis</creatorcontrib><creatorcontrib>Lien, Mei-Ching</creatorcontrib><creatorcontrib>Maleki, Jahangir</creatorcontrib><creatorcontrib>Luciano, Mark G</creatorcontrib><title>Task-specific and general cognitive effects in Chiari malformation type I</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Our objective was to use episodic memory and executive function tests to determine whether or not Chiari Malformation Type I (CM) patients experience cognitive dysfunction.
CM is a neurological syndrome in which the cerebellum descends into the cervical spine causing neural compression, severe headaches, neck pain, and number of other physical symptoms. While primarily a disorder of the cervico-medullary junction, both clinicians and researchers have suspected deficits in higher-level cognitive function.
We tested 24 CM patients who had undergone decompression neurosurgery and 24 age- and education-matched controls on measures of immediate and delayed episodic memory, as well as three measures of executive function.
The CM group showed performance decrements relative to the controls in response inhibition (Stroop interference), working memory computational speed (Ospan), and processing speed (automated digit symbol substitution task), but group differences in recall did not reach statistical significance. After statistical control for depression and anxiety scores, the group effects for working memory and processing speed were eliminated, but not for response inhibition. This response inhibition difference was not due to overall general slowing for the CM group, either, because when controls' data were transformed using the linear function fit to all of the reaction time tasks, the interaction with group remained statistically significant. Furthermore, there was a multivariate group effect for all of the response time measures and immediate and delayed recall after statistical control of depression and anxiety scores.
These results suggest that CM patients with decompression surgery exhibit cognitive dysfunction compared to age- and education-matched controls. While some of these results may be related to anxiety and depression (likely proxies for chronic pain), response inhibition effects, in particular, as well as a general cognitive deficit persisted even after control for anxiety and decompression.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age differences</subject><subject>Aging</subject><subject>Anxiety</subject><subject>Arnold-Chiari Malformation - physiopathology</subject><subject>Biology and Life Sciences</subject><subject>Brain</subject><subject>Brain research</subject><subject>Care and treatment</subject><subject>Cerebellum</subject><subject>Chronic pain</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Compression</subject><subject>Computational neuroscience</subject><subject>Computer memory</subject><subject>Congenital defects</subject><subject>Decompression</subject><subject>Depression, Mental</subject><subject>Diagnosis</subject><subject>Education</subject><subject>Executive function</subject><subject>Executive Function - physiology</subject><subject>Female</subject><subject>Group effects</subject><subject>Headache</subject><subject>Humans</subject><subject>Inhibition</subject><subject>Inhibition (psychology)</subject><subject>Linear functions</subject><subject>Male</subject><subject>Mechanical engineering</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Memory</subject><subject>Memory, Episodic</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Neck</subject><subject>Neural tube defects</subject><subject>Neurosurgery</subject><subject>Pain</subject><subject>Patients</subject><subject>Psychology</subject><subject>Reaction time</subject><subject>Reaction Time - physiology</subject><subject>Reaction time task</subject><subject>Recall</subject><subject>Response time</subject><subject>Risk factors</subject><subject>Short term memory</subject><subject>Social Sciences</subject><subject>Spine</subject><subject>Spine (cervical)</subject><subject>Statistical analysis</subject><subject>Statistical significance</subject><subject>Statistics</subject><subject>Stroop Test</subject><subject>Substitution reactions</subject><subject>Surgery</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl-P1CAUxRujcdfVb2C0iYnRhxmhUAovJpuJfybZZBNdfSWUXjqMbRmBbtxvL7PT3UzNPhgeIPC758LhZNlLjJaYVPjD1o1-UN1y5wZYIiQop_RRdooFKRasQOTx0fokexbCFqGScMaeZicFrQhjFTvN1lcq_FqEHWhrrM7V0OQtDOBVl2vXDjbaa8jBGNAx5HbIVxurvM171RnnexWtG_J4s4N8_Tx7YlQX4MU0n2U_Pn-6Wn1dXFx-Wa_OLxaaiSIuqEGqrjkn2jQNsBIVDCFDRVVghigtiCC6JNDUNF1VaQBMmoI3hhKsRU2BnGWvD7q7zgU5uRAkFlVVUUYQSsT6QDRObeXO2175G-mUlbcbzrdS-Wh1B5JQUSujk1GMUMSMqAhHJVaUJjvxbbePU7ex7qHRMMTkzUx0fjLYjWzdtSSCc8RxEng3CXj3e4QQZW-Dhq5TA7gx3bvEFecFQTShb_5BH37dRLUqPcAOxqW-ei8qz0lVlpwIUSRq-QCVRgO91Skyxqb9WcH7WUFiIvyJrRpDkOvv3_6fvfw5Z98esRtQXdwE14375IQ5SA-g9i4ED-beZIzkPvF3bsh94uWU-FT26viD7ovuIk7-Aiev-Wo</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Allen, Philip A</creator><creator>Houston, James R</creator><creator>Pollock, Joshua W</creator><creator>Buzzelli, Christopher</creator><creator>Li, Xuan</creator><creator>Harrington, A Katherine</creator><creator>Martin, Bryn A</creator><creator>Loth, Francis</creator><creator>Lien, Mei-Ching</creator><creator>Maleki, Jahangir</creator><creator>Luciano, Mark G</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140401</creationdate><title>Task-specific and general cognitive effects in Chiari malformation type I</title><author>Allen, Philip A ; Houston, James R ; Pollock, Joshua W ; Buzzelli, Christopher ; Li, Xuan ; Harrington, A Katherine ; Martin, Bryn A ; Loth, Francis ; Lien, Mei-Ching ; Maleki, Jahangir ; Luciano, Mark G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-4f0abb883cfdde6502600f4972160442393c53edb4866acee13d28df431c9b4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age differences</topic><topic>Aging</topic><topic>Anxiety</topic><topic>Arnold-Chiari Malformation - physiopathology</topic><topic>Biology and Life Sciences</topic><topic>Brain</topic><topic>Brain research</topic><topic>Care and treatment</topic><topic>Cerebellum</topic><topic>Chronic pain</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Compression</topic><topic>Computational neuroscience</topic><topic>Computer memory</topic><topic>Congenital defects</topic><topic>Decompression</topic><topic>Depression, Mental</topic><topic>Diagnosis</topic><topic>Education</topic><topic>Executive function</topic><topic>Executive Function - physiology</topic><topic>Female</topic><topic>Group effects</topic><topic>Headache</topic><topic>Humans</topic><topic>Inhibition</topic><topic>Inhibition (psychology)</topic><topic>Linear functions</topic><topic>Male</topic><topic>Mechanical engineering</topic><topic>Medical imaging</topic><topic>Medicine and Health Sciences</topic><topic>Memory</topic><topic>Memory, Episodic</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Neck</topic><topic>Neural tube defects</topic><topic>Neurosurgery</topic><topic>Pain</topic><topic>Patients</topic><topic>Psychology</topic><topic>Reaction time</topic><topic>Reaction Time - physiology</topic><topic>Reaction time task</topic><topic>Recall</topic><topic>Response time</topic><topic>Risk factors</topic><topic>Short term memory</topic><topic>Social Sciences</topic><topic>Spine</topic><topic>Spine (cervical)</topic><topic>Statistical analysis</topic><topic>Statistical significance</topic><topic>Statistics</topic><topic>Stroop Test</topic><topic>Substitution reactions</topic><topic>Surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allen, Philip A</creatorcontrib><creatorcontrib>Houston, James R</creatorcontrib><creatorcontrib>Pollock, Joshua W</creatorcontrib><creatorcontrib>Buzzelli, Christopher</creatorcontrib><creatorcontrib>Li, Xuan</creatorcontrib><creatorcontrib>Harrington, A Katherine</creatorcontrib><creatorcontrib>Martin, Bryn A</creatorcontrib><creatorcontrib>Loth, Francis</creatorcontrib><creatorcontrib>Lien, Mei-Ching</creatorcontrib><creatorcontrib>Maleki, Jahangir</creatorcontrib><creatorcontrib>Luciano, Mark G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allen, Philip A</au><au>Houston, James R</au><au>Pollock, Joshua W</au><au>Buzzelli, Christopher</au><au>Li, Xuan</au><au>Harrington, A Katherine</au><au>Martin, Bryn A</au><au>Loth, Francis</au><au>Lien, Mei-Ching</au><au>Maleki, Jahangir</au><au>Luciano, Mark G</au><au>Sutherland, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Task-specific and general cognitive effects in Chiari malformation type I</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>9</volume><issue>4</issue><spage>e94844</spage><epage>e94844</epage><pages>e94844-e94844</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Our objective was to use episodic memory and executive function tests to determine whether or not Chiari Malformation Type I (CM) patients experience cognitive dysfunction.
CM is a neurological syndrome in which the cerebellum descends into the cervical spine causing neural compression, severe headaches, neck pain, and number of other physical symptoms. While primarily a disorder of the cervico-medullary junction, both clinicians and researchers have suspected deficits in higher-level cognitive function.
We tested 24 CM patients who had undergone decompression neurosurgery and 24 age- and education-matched controls on measures of immediate and delayed episodic memory, as well as three measures of executive function.
The CM group showed performance decrements relative to the controls in response inhibition (Stroop interference), working memory computational speed (Ospan), and processing speed (automated digit symbol substitution task), but group differences in recall did not reach statistical significance. After statistical control for depression and anxiety scores, the group effects for working memory and processing speed were eliminated, but not for response inhibition. This response inhibition difference was not due to overall general slowing for the CM group, either, because when controls' data were transformed using the linear function fit to all of the reaction time tasks, the interaction with group remained statistically significant. Furthermore, there was a multivariate group effect for all of the response time measures and immediate and delayed recall after statistical control of depression and anxiety scores.
These results suggest that CM patients with decompression surgery exhibit cognitive dysfunction compared to age- and education-matched controls. While some of these results may be related to anxiety and depression (likely proxies for chronic pain), response inhibition effects, in particular, as well as a general cognitive deficit persisted even after control for anxiety and decompression.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24736676</pmid><doi>10.1371/journal.pone.0094844</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-04, Vol.9 (4), p.e94844-e94844 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1977746300 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Age differences Aging Anxiety Arnold-Chiari Malformation - physiopathology Biology and Life Sciences Brain Brain research Care and treatment Cerebellum Chronic pain Cognition Cognitive ability Compression Computational neuroscience Computer memory Congenital defects Decompression Depression, Mental Diagnosis Education Executive function Executive Function - physiology Female Group effects Headache Humans Inhibition Inhibition (psychology) Linear functions Male Mechanical engineering Medical imaging Medicine and Health Sciences Memory Memory, Episodic Mental depression Middle Aged Neck Neural tube defects Neurosurgery Pain Patients Psychology Reaction time Reaction Time - physiology Reaction time task Recall Response time Risk factors Short term memory Social Sciences Spine Spine (cervical) Statistical analysis Statistical significance Statistics Stroop Test Substitution reactions Surgery Young Adult |
| title | Task-specific and general cognitive effects in Chiari malformation type I |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T10%3A27%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Task-specific%20and%20general%20cognitive%20effects%20in%20Chiari%20malformation%20type%20I&rft.jtitle=PloS%20one&rft.au=Allen,%20Philip%20A&rft.date=2014-04-01&rft.volume=9&rft.issue=4&rft.spage=e94844&rft.epage=e94844&rft.pages=e94844-e94844&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0094844&rft_dat=%3Cgale_plos_%3EA375583992%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1977746300&rft_id=info:pmid/24736676&rft_galeid=A375583992&rft_doaj_id=oai_doaj_org_article_349bafc19363406f9738051a4448414e&rfr_iscdi=true |