Major and minor group rhinoviruses elicit differential signaling and cytokine responses as a function of receptor-mediated signal transduction

Major- and minor-group human rhinoviruses (HRV) enter their host by binding to the cell surface molecules ICAM-1 and LDL-R, respectively, which are present on both macrophages and epithelial cells. Although epithelial cells are the primary site of productive HRV infection, previous studies have impl...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e93897-e93897
Hauptverfasser:	Schuler, Bryce A, Schreiber, Michael T, Li, Luyuan, Mokry, Michal, Kingdon, Megan L, Raugi, Dana N, Smith, Cosonya, Hameister, Chelsea, Racaniello, Vincent R, Hall, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating transcription factor 2 Activation Analysis Asthma Biology and life sciences CCL20 protein Cell activation Cell Line Cell surface Cellular signal transduction Chemokines Cyclic AMP response element-binding protein Cytokines Cytokines - genetics Cytokines - metabolism Disease Distribution Epithelial cells Gene expression Gene Expression Regulation Genetic aspects Health aspects Humans Immunology Infections Inflammation Inflammation Mediators - metabolism Intercellular adhesion molecule 1 Interleukin 10 JNK protein Kinases Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - virology Ligands Lipoproteins (low density) Low density lipoprotein Macrophages Macrophages - metabolism Macrophages - virology MAP kinase Medicine and Health Sciences Membrane Potential, Mitochondrial Mitochondria Mitogen-Activated Protein Kinases - metabolism Monocyte chemoattractant protein 1 Pathogenesis Phosphorylation Picornaviridae Infections - metabolism Proteins Receptors, Virus - metabolism Respiratory tract Rhinovirus Rhinovirus - physiology Rhinoviruses RNA, Messenger - genetics Serotypes Signal Transduction Signaling Surgeons Transcription factors Transcription Factors - metabolism Transduction Viral infections Virus Replication Viruses
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