Activated macrophage survival is coordinated by TAK1 binding proteins

Macrophages play diverse roles in tissue homeostasis and immunity, and canonically activated macrophages are critically associated with acute inflammatory responses. It is known that activated macrophages undergo cell death after transient activation in some settings, and the viability of macrophage...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e94982
Hauptverfasser:	Mihaly, September R, Morioka, Sho, Ninomiya-Tsuji, Jun, Takaesu, Giichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis Binding Binding proteins Biology and Life Sciences Bone marrow Cell activation Cell death Cell Death - drug effects Cell Death - immunology Cell survival Cell Survival - genetics Chemical properties Clonal deletion Experiments Gene Deletion Genetic aspects GTPase-Activating Proteins - antagonists & inhibitors GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism Homeostasis Immunity Inflammation Kinases Lipopolysaccharides Lipopolysaccharides - immunology Macrophage Activation - genetics Macrophage Activation - immunology Macrophages Macrophages - immunology Macrophages - metabolism MAP Kinase Kinase Kinases - genetics Mice Mice, Knockout Microorganisms Morphogenesis Mortality Peritoneum Physiological aspects Protein kinases Proteins Research and Analysis Methods Survival TAK1 protein Toxicology Tumor necrosis factor-TNF Viability
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