Non-tuberculous mycobacteria and the performance of interferon gamma release assays in Denmark
The QuantiFERON-TB-Gold Test (QFT) is more specific than the Mantoux skin-test to discriminate between Mycobacterium tuberculosis (MTB) and non-tuberculous mycobacterial (NTM) infections. Here we study the performance of the QFT in patients with NTM disease. From 2005 to 2011, nationwide patient dat...
Gespeichert in:
| Veröffentlicht in: | PloS one 2014-04, Vol.9 (4), p.e93986 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 4 |
| container_start_page | e93986 |
| container_title | PloS one |
| container_volume | 9 |
| creator | Hermansen, Thomas Stig Thomsen, Vibeke Østergaard Lillebaek, Troels Ravn, Pernille |
| description | The QuantiFERON-TB-Gold Test (QFT) is more specific than the Mantoux skin-test to discriminate between Mycobacterium tuberculosis (MTB) and non-tuberculous mycobacterial (NTM) infections. Here we study the performance of the QFT in patients with NTM disease.
From 2005 to 2011, nationwide patient data on positive NTM cultures (n = 925) were combined with nationwide data on QFT results (n = 16,133), both retrieved from the International Reference Laboratory of Mycobacteriology, Denmark. A total of 112 patients with NTM infections had a QFT performed, 53 patients had definite NTM disease, 10 had possible disease and 49 had NTM colonization.
QFT was positive in 8% (4/53) of patients with definite disease, 40% (4/10) with possible disease and 31% (15/49) with colonization. Positivity rate was lowest among patients with definite disease infected with NTM without the RD1 region 4% (2/50). None of the 15 children with MAC lymphadenitis had a positive QFT.
This study is one of the largest assessing IGRAs in patients with NTM disease in a TB low-incidence setting. Our study showed that the QFT holds potential to discriminate between NTM and MTB infections. We found no positive IGRA test results among children with NTM not sharing the RD1-region of MTB resulting in a 100% specificity and we suggest that a QFT in a child presenting with cervical lymphadenitis may be helpful in distinguishing NTM from TB lymphadenitis. |
| doi_str_mv | 10.1371/journal.pone.0093986 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1977745830</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A375583226</galeid><doaj_id>oai_doaj_org_article_b8b79df4ef12477b8b76e9fff356e915</doaj_id><sourcerecordid>A375583226</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-def2941e052f85cddff2c6591c6d6b11189f354a3c0ccac7970d28024f0a09e83</originalsourceid><addsrcrecordid>eNqNk02P0zAQhiMEYpeFf4AgEhKCQ4sdx3Z8QVotX5VWrMTXEWvijNuUxC52gui_x6XZVYv2gHwY2_PMa8_Yk2WPKZlTJumrtR-Dg26-8Q7nhCimKnEnO6WKFTNREHb3YH6SPYhxTQhnlRD3s5OilIQLyU-z7x-9mw1jjcGMnR9j3m-Nr8EMGFrIwTX5sMJ8g8H60IMzmHubty65LQbv8iX0PeQBO4SIOcQI25j8-Rt0PYQfD7N7FrqIjyZ7ln199_bLxYfZ5dX7xcX55cwIVQyzBm2hSoqEF7bipmmsLYzgihrRiJpSWinLeAnMEGPASCVJU1SkKC0BorBiZ9nTve6m81FPpYmaKillyStGErHYE42Htd6ENl1vqz20-u-GD0sNYWhNh7quaqkaW6KlqVBytxSorE1XSJbypPV6Om2se2wMuiFAdyR67HHtSi_9L82UFEzIJPBiEgj-54hx0H0bDXYdOEyPoCmnZck4J7vMnv2D3p7dRC0hJdA669O5Zieqz5nkiSkKkaj5LVQaDfatSf_Itmn_KODlUUBiBvw9LGGMUS8-f_p_9urbMfv8gF0hdMMq-m4cWu_iMVjuQRN8jAHtTZEp0bs2uK6G3rWBntoghT05fKCboOt_z_4AP8MDVw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1977745830</pqid></control><display><type>article</type><title>Non-tuberculous mycobacteria and the performance of interferon gamma release assays in Denmark</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Hermansen, Thomas Stig ; Thomsen, Vibeke Østergaard ; Lillebaek, Troels ; Ravn, Pernille</creator><contributor>Herrmann, Jean Louis</contributor><creatorcontrib>Hermansen, Thomas Stig ; Thomsen, Vibeke Østergaard ; Lillebaek, Troels ; Ravn, Pernille ; Herrmann, Jean Louis</creatorcontrib><description>The QuantiFERON-TB-Gold Test (QFT) is more specific than the Mantoux skin-test to discriminate between Mycobacterium tuberculosis (MTB) and non-tuberculous mycobacterial (NTM) infections. Here we study the performance of the QFT in patients with NTM disease.
From 2005 to 2011, nationwide patient data on positive NTM cultures (n = 925) were combined with nationwide data on QFT results (n = 16,133), both retrieved from the International Reference Laboratory of Mycobacteriology, Denmark. A total of 112 patients with NTM infections had a QFT performed, 53 patients had definite NTM disease, 10 had possible disease and 49 had NTM colonization.
QFT was positive in 8% (4/53) of patients with definite disease, 40% (4/10) with possible disease and 31% (15/49) with colonization. Positivity rate was lowest among patients with definite disease infected with NTM without the RD1 region 4% (2/50). None of the 15 children with MAC lymphadenitis had a positive QFT.
This study is one of the largest assessing IGRAs in patients with NTM disease in a TB low-incidence setting. Our study showed that the QFT holds potential to discriminate between NTM and MTB infections. We found no positive IGRA test results among children with NTM not sharing the RD1-region of MTB resulting in a 100% specificity and we suggest that a QFT in a child presenting with cervical lymphadenitis may be helpful in distinguishing NTM from TB lymphadenitis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0093986</identifier><identifier>PMID: 24705675</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Antigens ; Biological response modifiers ; Biology and Life Sciences ; Care and treatment ; Children ; Colonization ; Databases, Factual ; Denmark - epidemiology ; Diagnosis ; Ethics ; Female ; Health aspects ; Humans ; Infections ; Infectious diseases ; Interferon ; Interferon gamma ; Interferon-gamma Release Tests ; Laboratories ; Lung diseases ; Lymphadenitis ; Male ; Medical diagnosis ; Medical research ; Medicine and Health Sciences ; Meta-Analysis as Topic ; Middle Aged ; Mycobacterium Infections, Nontuberculous - diagnosis ; Mycobacterium Infections, Nontuberculous - epidemiology ; Nontuberculous Mycobacteria - immunology ; Patients ; Registries ; Reproducibility of Results ; Retrospective Studies ; Skin tests ; Studies ; Tuberculosis</subject><ispartof>PloS one, 2014-04, Vol.9 (4), p.e93986</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Hermansen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Hermansen et al 2014 Hermansen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-def2941e052f85cddff2c6591c6d6b11189f354a3c0ccac7970d28024f0a09e83</citedby><cites>FETCH-LOGICAL-c692t-def2941e052f85cddff2c6591c6d6b11189f354a3c0ccac7970d28024f0a09e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976367/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976367/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24705675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Herrmann, Jean Louis</contributor><creatorcontrib>Hermansen, Thomas Stig</creatorcontrib><creatorcontrib>Thomsen, Vibeke Østergaard</creatorcontrib><creatorcontrib>Lillebaek, Troels</creatorcontrib><creatorcontrib>Ravn, Pernille</creatorcontrib><title>Non-tuberculous mycobacteria and the performance of interferon gamma release assays in Denmark</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The QuantiFERON-TB-Gold Test (QFT) is more specific than the Mantoux skin-test to discriminate between Mycobacterium tuberculosis (MTB) and non-tuberculous mycobacterial (NTM) infections. Here we study the performance of the QFT in patients with NTM disease.
From 2005 to 2011, nationwide patient data on positive NTM cultures (n = 925) were combined with nationwide data on QFT results (n = 16,133), both retrieved from the International Reference Laboratory of Mycobacteriology, Denmark. A total of 112 patients with NTM infections had a QFT performed, 53 patients had definite NTM disease, 10 had possible disease and 49 had NTM colonization.
QFT was positive in 8% (4/53) of patients with definite disease, 40% (4/10) with possible disease and 31% (15/49) with colonization. Positivity rate was lowest among patients with definite disease infected with NTM without the RD1 region 4% (2/50). None of the 15 children with MAC lymphadenitis had a positive QFT.
This study is one of the largest assessing IGRAs in patients with NTM disease in a TB low-incidence setting. Our study showed that the QFT holds potential to discriminate between NTM and MTB infections. We found no positive IGRA test results among children with NTM not sharing the RD1-region of MTB resulting in a 100% specificity and we suggest that a QFT in a child presenting with cervical lymphadenitis may be helpful in distinguishing NTM from TB lymphadenitis.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens</subject><subject>Biological response modifiers</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Children</subject><subject>Colonization</subject><subject>Databases, Factual</subject><subject>Denmark - epidemiology</subject><subject>Diagnosis</subject><subject>Ethics</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Interferon</subject><subject>Interferon gamma</subject><subject>Interferon-gamma Release Tests</subject><subject>Laboratories</subject><subject>Lung diseases</subject><subject>Lymphadenitis</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Meta-Analysis as Topic</subject><subject>Middle Aged</subject><subject>Mycobacterium Infections, Nontuberculous - diagnosis</subject><subject>Mycobacterium Infections, Nontuberculous - epidemiology</subject><subject>Nontuberculous Mycobacteria - immunology</subject><subject>Patients</subject><subject>Registries</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Skin tests</subject><subject>Studies</subject><subject>Tuberculosis</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk02P0zAQhiMEYpeFf4AgEhKCQ4sdx3Z8QVotX5VWrMTXEWvijNuUxC52gui_x6XZVYv2gHwY2_PMa8_Yk2WPKZlTJumrtR-Dg26-8Q7nhCimKnEnO6WKFTNREHb3YH6SPYhxTQhnlRD3s5OilIQLyU-z7x-9mw1jjcGMnR9j3m-Nr8EMGFrIwTX5sMJ8g8H60IMzmHubty65LQbv8iX0PeQBO4SIOcQI25j8-Rt0PYQfD7N7FrqIjyZ7ln199_bLxYfZ5dX7xcX55cwIVQyzBm2hSoqEF7bipmmsLYzgihrRiJpSWinLeAnMEGPASCVJU1SkKC0BorBiZ9nTve6m81FPpYmaKillyStGErHYE42Htd6ENl1vqz20-u-GD0sNYWhNh7quaqkaW6KlqVBytxSorE1XSJbypPV6Om2se2wMuiFAdyR67HHtSi_9L82UFEzIJPBiEgj-54hx0H0bDXYdOEyPoCmnZck4J7vMnv2D3p7dRC0hJdA669O5Zieqz5nkiSkKkaj5LVQaDfatSf_Itmn_KODlUUBiBvw9LGGMUS8-f_p_9urbMfv8gF0hdMMq-m4cWu_iMVjuQRN8jAHtTZEp0bs2uK6G3rWBntoghT05fKCboOt_z_4AP8MDVw</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Hermansen, Thomas Stig</creator><creator>Thomsen, Vibeke Østergaard</creator><creator>Lillebaek, Troels</creator><creator>Ravn, Pernille</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140401</creationdate><title>Non-tuberculous mycobacteria and the performance of interferon gamma release assays in Denmark</title><author>Hermansen, Thomas Stig ; Thomsen, Vibeke Østergaard ; Lillebaek, Troels ; Ravn, Pernille</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-def2941e052f85cddff2c6591c6d6b11189f354a3c0ccac7970d28024f0a09e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigens</topic><topic>Biological response modifiers</topic><topic>Biology and Life Sciences</topic><topic>Care and treatment</topic><topic>Children</topic><topic>Colonization</topic><topic>Databases, Factual</topic><topic>Denmark - epidemiology</topic><topic>Diagnosis</topic><topic>Ethics</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Interferon</topic><topic>Interferon gamma</topic><topic>Interferon-gamma Release Tests</topic><topic>Laboratories</topic><topic>Lung diseases</topic><topic>Lymphadenitis</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Meta-Analysis as Topic</topic><topic>Middle Aged</topic><topic>Mycobacterium Infections, Nontuberculous - diagnosis</topic><topic>Mycobacterium Infections, Nontuberculous - epidemiology</topic><topic>Nontuberculous Mycobacteria - immunology</topic><topic>Patients</topic><topic>Registries</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Skin tests</topic><topic>Studies</topic><topic>Tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hermansen, Thomas Stig</creatorcontrib><creatorcontrib>Thomsen, Vibeke Østergaard</creatorcontrib><creatorcontrib>Lillebaek, Troels</creatorcontrib><creatorcontrib>Ravn, Pernille</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hermansen, Thomas Stig</au><au>Thomsen, Vibeke Østergaard</au><au>Lillebaek, Troels</au><au>Ravn, Pernille</au><au>Herrmann, Jean Louis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-tuberculous mycobacteria and the performance of interferon gamma release assays in Denmark</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>9</volume><issue>4</issue><spage>e93986</spage><pages>e93986-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The QuantiFERON-TB-Gold Test (QFT) is more specific than the Mantoux skin-test to discriminate between Mycobacterium tuberculosis (MTB) and non-tuberculous mycobacterial (NTM) infections. Here we study the performance of the QFT in patients with NTM disease.
From 2005 to 2011, nationwide patient data on positive NTM cultures (n = 925) were combined with nationwide data on QFT results (n = 16,133), both retrieved from the International Reference Laboratory of Mycobacteriology, Denmark. A total of 112 patients with NTM infections had a QFT performed, 53 patients had definite NTM disease, 10 had possible disease and 49 had NTM colonization.
QFT was positive in 8% (4/53) of patients with definite disease, 40% (4/10) with possible disease and 31% (15/49) with colonization. Positivity rate was lowest among patients with definite disease infected with NTM without the RD1 region 4% (2/50). None of the 15 children with MAC lymphadenitis had a positive QFT.
This study is one of the largest assessing IGRAs in patients with NTM disease in a TB low-incidence setting. Our study showed that the QFT holds potential to discriminate between NTM and MTB infections. We found no positive IGRA test results among children with NTM not sharing the RD1-region of MTB resulting in a 100% specificity and we suggest that a QFT in a child presenting with cervical lymphadenitis may be helpful in distinguishing NTM from TB lymphadenitis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24705675</pmid><doi>10.1371/journal.pone.0093986</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-04, Vol.9 (4), p.e93986 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1977745830 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Antigens Biological response modifiers Biology and Life Sciences Care and treatment Children Colonization Databases, Factual Denmark - epidemiology Diagnosis Ethics Female Health aspects Humans Infections Infectious diseases Interferon Interferon gamma Interferon-gamma Release Tests Laboratories Lung diseases Lymphadenitis Male Medical diagnosis Medical research Medicine and Health Sciences Meta-Analysis as Topic Middle Aged Mycobacterium Infections, Nontuberculous - diagnosis Mycobacterium Infections, Nontuberculous - epidemiology Nontuberculous Mycobacteria - immunology Patients Registries Reproducibility of Results Retrospective Studies Skin tests Studies Tuberculosis |
| title | Non-tuberculous mycobacteria and the performance of interferon gamma release assays in Denmark |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T17%3A58%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Non-tuberculous%20mycobacteria%20and%20the%20performance%20of%20interferon%20gamma%20release%20assays%20in%20Denmark&rft.jtitle=PloS%20one&rft.au=Hermansen,%20Thomas%20Stig&rft.date=2014-04-01&rft.volume=9&rft.issue=4&rft.spage=e93986&rft.pages=e93986-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0093986&rft_dat=%3Cgale_plos_%3EA375583226%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1977745830&rft_id=info:pmid/24705675&rft_galeid=A375583226&rft_doaj_id=oai_doaj_org_article_b8b79df4ef12477b8b76e9fff356e915&rfr_iscdi=true |