Variant B cell receptor isotype functions differ in hairy cell leukemia with mutated BRAF and IGHV genes

A functional B-cell receptor (BCR) is critical for survival of normal B-cells, but whether it plays a comparable role in B-cell malignancy is as yet not fully delineated. Typical Hairy Cell Leukemia (HCL) is a rare B-cell tumor, and unique in expressing multiple surface immunoglobulin (sIg) isotypes...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e86556-e86556
Hauptverfasser:	Weston-Bell, Nicola J, Forconi, Francesco, Kluin-Nelemans, Hanneke C, Sahota, Surinder S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antigens Apoptosis B cells B-cell receptor B-Lymphocytes - immunology B-Lymphocytes - metabolism Biology Calcium Calcium Signaling Cancer Cancer genetics Cell surface Cell survival Cells, Cultured Cellular signal transduction Clonal deletion Discordance DNA Mutational Analysis Drug dosages Endocytosis Extracellular Signal-Regulated MAP Kinases - metabolism Gene expression Genes Genetic aspects Genomes Hairy cell leukemia Hematology Humans Immunoglobulin D Immunoglobulin Heavy Chains - genetics Immunoglobulins Isotypes Kinases Leukemia Leukemia, Hairy Cell - genetics Leukemia, Hairy Cell - immunology Leukemia, Hairy Cell - pathology Lymphocytes B Lymphoma Malignancy Medicine Mutation Phosphorylation Protein Isoforms - metabolism Protein Processing, Post-Translational Proteins Proto-Oncogene Proteins B-raf - genetics Receptors, Immunologic - metabolism Signal transduction Signaling Stimuli Survival T cell receptors Tumor cells Tumors Viability
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