Vagal nerve stimulation triggers widespread responses and alters large-scale functional connectivity in the rat brain

Vagus nerve stimulation (VNS) is a therapy for epilepsy and depression. However, its efficacy varies and its mechanism remains unclear. Prior studies have used functional magnetic resonance imaging (fMRI) to map brain activations with VNS in human brains, but have reported inconsistent findings. The...

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Veröffentlicht in:	PloS one 2017-12, Vol.12 (12), p.e0189518-e0189518
Hauptverfasser:	Cao, Jiayue, Lu, Kun-Han, Powley, Terry L, Liu, Zhongming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cognition Animal models Animals Biology and Life Sciences Biomedical engineering Brain Brain - diagnostic imaging Brain - physiology Brain mapping Brain Mapping - methods Brain research Computer and Information Sciences Computer engineering Electrical stimuli Epilepsy Evaluation Evoked response (psychophysiology) Functional magnetic resonance imaging Independent component analysis Laboratory animals Limbic system Magnetic resonance Magnetic Resonance Imaging Male Medical imaging Medicine and Health Sciences Mental depression Methods Models, Biological Networks Neural networks Neural stimulation Neuroimaging Neurosciences NMR Nuclear magnetic resonance Oxygenation Rats Rats, Sprague-Dawley Research and Analysis Methods Rodents Stimulation Studies Tomography Vagus nerve Vagus Nerve Stimulation - methods
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