Microbiological profile and risk factors for in-hospital mortality of infective endocarditis in tertiary care hospitals of south Vietnam
We aimed to evaluate the microbiological characteristics and risk factors for mortality of infective endocarditis in two tertiary hospitals in Ho Chi Minh City, south Vietnam. A retrospective study of 189 patients (120 men, 69 women; mean age 38 ± 18 years) with the diagnosis of probable or definite...
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| Veröffentlicht in: | PloS one 2017-12, Vol.12 (12), p.e0189421-e0189421 |
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| creator | Tran, Hoang M Truong, Vien T Ngo, Tam M N Bui, Quoc P V Nguyen, Hoang C Le, Trung T Q Mazur, Wojciech Chung, Eugene Cafardi, John M Pham, Khanh P N Duong, Hoang H N Nguyen, Thach Nguyen, Vu T Pham, Vinh N |
| description | We aimed to evaluate the microbiological characteristics and risk factors for mortality of infective endocarditis in two tertiary hospitals in Ho Chi Minh City, south Vietnam.
A retrospective study of 189 patients (120 men, 69 women; mean age 38 ± 18 years) with the diagnosis of probable or definite infective endocarditis (IE) according to the modified Duke Criteria admitted to The Heart Institute or Tam Duc Hospital between January 2005 and December 2014.
IE was related to a native valve in 165 patients (87.3%), and prosthetic valve in 24 (12.7%). Of the 189 patients in our series, the culture positive rate was 70.4%. The most common isolated pathogens were Streptococci (75.2%), Staphylococci (9.8%) followed by gram negative organism (4.5%). The sensitivity rate of Streptococci to ampicillin, ceftriaxone or vancomycin was 100%. The rate of methicillin resistant Staphylococcus aureus was 40%. There was a decrease in penicillin sensitivity for Streptococci over three eras: 2005-2007 (100%), 2008-2010 (94%) and 2010-2014 (84%). The in-hospital mortality rate was 6.9%. Logistic regression analysis found prosthetic valve and NYHA grade 3 or 4 heart failure and vegetation size of more than 15 mm as strong predictors of in-hospital mortality.
Streptococcal species were the major pathogen of IE in the recent years with low rates of antimicrobial resistance. Prosthetic valve involvement, moderate or severe heart failure and vegetation size of more than 15 mm were independent predictors for in-hospital mortality in IE. |
| doi_str_mv | 10.1371/journal.pone.0189421 |
| format | Article |
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A retrospective study of 189 patients (120 men, 69 women; mean age 38 ± 18 years) with the diagnosis of probable or definite infective endocarditis (IE) according to the modified Duke Criteria admitted to The Heart Institute or Tam Duc Hospital between January 2005 and December 2014.
IE was related to a native valve in 165 patients (87.3%), and prosthetic valve in 24 (12.7%). Of the 189 patients in our series, the culture positive rate was 70.4%. The most common isolated pathogens were Streptococci (75.2%), Staphylococci (9.8%) followed by gram negative organism (4.5%). The sensitivity rate of Streptococci to ampicillin, ceftriaxone or vancomycin was 100%. The rate of methicillin resistant Staphylococcus aureus was 40%. There was a decrease in penicillin sensitivity for Streptococci over three eras: 2005-2007 (100%), 2008-2010 (94%) and 2010-2014 (84%). The in-hospital mortality rate was 6.9%. Logistic regression analysis found prosthetic valve and NYHA grade 3 or 4 heart failure and vegetation size of more than 15 mm as strong predictors of in-hospital mortality.
Streptococcal species were the major pathogen of IE in the recent years with low rates of antimicrobial resistance. Prosthetic valve involvement, moderate or severe heart failure and vegetation size of more than 15 mm were independent predictors for in-hospital mortality in IE.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0189421</identifier><identifier>PMID: 29240776</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Ampicillin ; Analysis ; Antibiotics ; Antimicrobial resistance ; Biology and Life Sciences ; Blood ; Cardiology ; Ceftriaxone ; Congenital diseases ; Endocarditis ; Endocarditis - epidemiology ; Endocarditis - microbiology ; Epidemiology ; Female ; Health risk assessment ; Health risks ; Heart ; Heart diseases ; Heart failure ; Hospital Mortality ; Hospitals ; Humans ; Infectious diseases ; Infective endocarditis ; Male ; Medicine ; Medicine and Health Sciences ; Methicillin ; Middle Aged ; Mortality ; Oral hygiene ; Pathogens ; Patients ; Penicillin ; Prostheses ; Quality ; Regression analysis ; Retrospective Studies ; Risk analysis ; Risk Factors ; Sensitivity ; Slopes ; Staphylococcus aureus ; Statistical analysis ; Tertiary Care Centers ; Vancomycin ; Vegetation ; Vietnam ; Vietnam - epidemiology ; Young Adult</subject><ispartof>PloS one, 2017-12, Vol.12 (12), p.e0189421-e0189421</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Tran et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Tran et al 2017 Tran et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5001-6b16d4d5b73d3db30680d06718937561f0c854ec578ba0832b2493d1d59a7dbd3</citedby><cites>FETCH-LOGICAL-c5001-6b16d4d5b73d3db30680d06718937561f0c854ec578ba0832b2493d1d59a7dbd3</cites><orcidid>0000-0002-8620-800X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730146/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730146/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29240776$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tran, Hoang M</creatorcontrib><creatorcontrib>Truong, Vien T</creatorcontrib><creatorcontrib>Ngo, Tam M N</creatorcontrib><creatorcontrib>Bui, Quoc P V</creatorcontrib><creatorcontrib>Nguyen, Hoang C</creatorcontrib><creatorcontrib>Le, Trung T Q</creatorcontrib><creatorcontrib>Mazur, Wojciech</creatorcontrib><creatorcontrib>Chung, Eugene</creatorcontrib><creatorcontrib>Cafardi, John M</creatorcontrib><creatorcontrib>Pham, Khanh P N</creatorcontrib><creatorcontrib>Duong, Hoang H N</creatorcontrib><creatorcontrib>Nguyen, Thach</creatorcontrib><creatorcontrib>Nguyen, Vu T</creatorcontrib><creatorcontrib>Pham, Vinh N</creatorcontrib><title>Microbiological profile and risk factors for in-hospital mortality of infective endocarditis in tertiary care hospitals of south Vietnam</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We aimed to evaluate the microbiological characteristics and risk factors for mortality of infective endocarditis in two tertiary hospitals in Ho Chi Minh City, south Vietnam.
A retrospective study of 189 patients (120 men, 69 women; mean age 38 ± 18 years) with the diagnosis of probable or definite infective endocarditis (IE) according to the modified Duke Criteria admitted to The Heart Institute or Tam Duc Hospital between January 2005 and December 2014.
IE was related to a native valve in 165 patients (87.3%), and prosthetic valve in 24 (12.7%). Of the 189 patients in our series, the culture positive rate was 70.4%. The most common isolated pathogens were Streptococci (75.2%), Staphylococci (9.8%) followed by gram negative organism (4.5%). The sensitivity rate of Streptococci to ampicillin, ceftriaxone or vancomycin was 100%. The rate of methicillin resistant Staphylococcus aureus was 40%. There was a decrease in penicillin sensitivity for Streptococci over three eras: 2005-2007 (100%), 2008-2010 (94%) and 2010-2014 (84%). The in-hospital mortality rate was 6.9%. Logistic regression analysis found prosthetic valve and NYHA grade 3 or 4 heart failure and vegetation size of more than 15 mm as strong predictors of in-hospital mortality.
Streptococcal species were the major pathogen of IE in the recent years with low rates of antimicrobial resistance. Prosthetic valve involvement, moderate or severe heart failure and vegetation size of more than 15 mm were independent predictors for in-hospital mortality in IE.</description><subject>Adult</subject><subject>Ampicillin</subject><subject>Analysis</subject><subject>Antibiotics</subject><subject>Antimicrobial resistance</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Cardiology</subject><subject>Ceftriaxone</subject><subject>Congenital diseases</subject><subject>Endocarditis</subject><subject>Endocarditis - epidemiology</subject><subject>Endocarditis - microbiology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Heart failure</subject><subject>Hospital Mortality</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Infective endocarditis</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Methicillin</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Oral hygiene</subject><subject>Pathogens</subject><subject>Patients</subject><subject>Penicillin</subject><subject>Prostheses</subject><subject>Quality</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Sensitivity</subject><subject>Slopes</subject><subject>Staphylococcus aureus</subject><subject>Statistical analysis</subject><subject>Tertiary Care Centers</subject><subject>Vancomycin</subject><subject>Vegetation</subject><subject>Vietnam</subject><subject>Vietnam - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tran, Hoang M</au><au>Truong, Vien T</au><au>Ngo, Tam M N</au><au>Bui, Quoc P V</au><au>Nguyen, Hoang C</au><au>Le, Trung T Q</au><au>Mazur, Wojciech</au><au>Chung, Eugene</au><au>Cafardi, John M</au><au>Pham, Khanh P N</au><au>Duong, Hoang H N</au><au>Nguyen, Thach</au><au>Nguyen, Vu T</au><au>Pham, Vinh N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microbiological profile and risk factors for in-hospital mortality of infective endocarditis in tertiary care hospitals of south Vietnam</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-12-14</date><risdate>2017</risdate><volume>12</volume><issue>12</issue><spage>e0189421</spage><epage>e0189421</epage><pages>e0189421-e0189421</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We aimed to evaluate the microbiological characteristics and risk factors for mortality of infective endocarditis in two tertiary hospitals in Ho Chi Minh City, south Vietnam.
A retrospective study of 189 patients (120 men, 69 women; mean age 38 ± 18 years) with the diagnosis of probable or definite infective endocarditis (IE) according to the modified Duke Criteria admitted to The Heart Institute or Tam Duc Hospital between January 2005 and December 2014.
IE was related to a native valve in 165 patients (87.3%), and prosthetic valve in 24 (12.7%). Of the 189 patients in our series, the culture positive rate was 70.4%. The most common isolated pathogens were Streptococci (75.2%), Staphylococci (9.8%) followed by gram negative organism (4.5%). The sensitivity rate of Streptococci to ampicillin, ceftriaxone or vancomycin was 100%. The rate of methicillin resistant Staphylococcus aureus was 40%. There was a decrease in penicillin sensitivity for Streptococci over three eras: 2005-2007 (100%), 2008-2010 (94%) and 2010-2014 (84%). The in-hospital mortality rate was 6.9%. Logistic regression analysis found prosthetic valve and NYHA grade 3 or 4 heart failure and vegetation size of more than 15 mm as strong predictors of in-hospital mortality.
Streptococcal species were the major pathogen of IE in the recent years with low rates of antimicrobial resistance. Prosthetic valve involvement, moderate or severe heart failure and vegetation size of more than 15 mm were independent predictors for in-hospital mortality in IE.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29240776</pmid><doi>10.1371/journal.pone.0189421</doi><orcidid>https://orcid.org/0000-0002-8620-800X</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-12, Vol.12 (12), p.e0189421-e0189421 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1977206791 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Ampicillin Analysis Antibiotics Antimicrobial resistance Biology and Life Sciences Blood Cardiology Ceftriaxone Congenital diseases Endocarditis Endocarditis - epidemiology Endocarditis - microbiology Epidemiology Female Health risk assessment Health risks Heart Heart diseases Heart failure Hospital Mortality Hospitals Humans Infectious diseases Infective endocarditis Male Medicine Medicine and Health Sciences Methicillin Middle Aged Mortality Oral hygiene Pathogens Patients Penicillin Prostheses Quality Regression analysis Retrospective Studies Risk analysis Risk Factors Sensitivity Slopes Staphylococcus aureus Statistical analysis Tertiary Care Centers Vancomycin Vegetation Vietnam Vietnam - epidemiology Young Adult |
| title | Microbiological profile and risk factors for in-hospital mortality of infective endocarditis in tertiary care hospitals of south Vietnam |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T23%3A10%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microbiological%20profile%20and%20risk%20factors%20for%20in-hospital%20mortality%20of%20infective%20endocarditis%20in%20tertiary%20care%20hospitals%20of%20south%20Vietnam&rft.jtitle=PloS%20one&rft.au=Tran,%20Hoang%20M&rft.date=2017-12-14&rft.volume=12&rft.issue=12&rft.spage=e0189421&rft.epage=e0189421&rft.pages=e0189421-e0189421&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0189421&rft_dat=%3Cgale_plos_%3EA518856113%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1977206791&rft_id=info:pmid/29240776&rft_galeid=A518856113&rft_doaj_id=oai_doaj_org_article_6fd49fde77f84d2980642b86b4c245d6&rfr_iscdi=true |