Sedentary time and markers of chronic low-grade inflammation in a high risk population
Sedentary behaviour has been identified as a distinct risk factor for several health outcomes. Nevertheless, little research has been conducted into the underlying mechanisms driving these observations. This study aimed to investigate the association of objectively measured sedentary time and breaks...
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| description | Sedentary behaviour has been identified as a distinct risk factor for several health outcomes. Nevertheless, little research has been conducted into the underlying mechanisms driving these observations. This study aimed to investigate the association of objectively measured sedentary time and breaks in sedentary time with markers of chronic low-grade inflammation and adiposity in a population at a high risk of type 2 diabetes mellitus.
This study reports data from an ongoing diabetes prevention programme conducted in Leicestershire, UK. High risk individuals were recruited from 10 primary care practices. Sedentary time (10 mg/L, as this can be indicative of acute inflammation.
558 participants (age = 63.6±7.7 years; male = 64.7%) had complete adipokine and accelerometer data. Following adjustment for various confounders, sedentary time was detrimentally associated with CRP (β = 0.176±0.057, p = 0.002), IL-6 (β = 0.242±0.056, p = |
| doi_str_mv | 10.1371/journal.pone.0078350 |
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This study reports data from an ongoing diabetes prevention programme conducted in Leicestershire, UK. High risk individuals were recruited from 10 primary care practices. Sedentary time (<25 counts per 15 s) was measured using Actigraph GT3X accelerometers (15 s epochs). A break was considered as any interruption in sedentary time (≥25 counts per 15 s). Biochemical outcomes included interleukin-6 (IL-6), C-reactive protein (CRP), leptin, adiponectin and leptin:adiponectin ratio (LAR). A sensitivity analysis investigated whether results were affected by removing participants with a CRP level >10 mg/L, as this can be indicative of acute inflammation.
558 participants (age = 63.6±7.7 years; male = 64.7%) had complete adipokine and accelerometer data. Following adjustment for various confounders, sedentary time was detrimentally associated with CRP (β = 0.176±0.057, p = 0.002), IL-6 (β = 0.242±0.056, p = <0.001), leptin (β = 0.146±0.043, p = <0.001) and LAR (β = 0.208±0.052, p = <0.001). Associations were attenuated after further adjustment for moderate-to-vigorous physical activity (MVPA) with only IL-6 (β = 0.231±0.073, p = 0.002) remaining significant; this result was unaffected after further adjustment for body mass index and glycosylated haemoglobin (HbA1c). Similarly, breaks in sedentary time were significantly inversely associated with IL-6 (β = -0.094±0.047, p = 0.045) and leptin (β = -0.075±0.037, p = 0.039); however, these associations were attenuated after adjustment for accelerometer derived variables. Excluding individuals with a CRP level >10 mg/L consistently attenuated the significant associations across all markers of inflammation.
These novel findings from a high risk population recruited through primary care suggest that sedentary behaviour may influence markers associated with inflammation, independent of MVPA, glycaemia and adiposity.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0078350</identifier><identifier>PMID: 24205208</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accelerometers ; Adiponectin ; Adiponectin - metabolism ; Adipose tissue ; Adiposity - physiology ; Adjustment ; Attenuation ; Automation ; Biomarkers - metabolism ; Biomedical research ; Blood glucose ; Body mass ; Body Mass Index ; Body size ; C-reactive protein ; C-Reactive Protein - metabolism ; Cardiovascular disease ; Chronic illnesses ; Cytokines ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - physiopathology ; Disease control ; Female ; Glycated Hemoglobin A - metabolism ; Health care ; Health risks ; Hemoglobin ; Humans ; Inflammation ; Inflammation - metabolism ; Inflammation - pathology ; Insulin resistance ; Interleukin ; Interleukin 6 ; Interleukin-6 - metabolism ; Leptin ; Leptin - metabolism ; Lifestyles ; Male ; Markers ; Medical research ; Medicine ; Metabolism ; Middle Aged ; Motor Activity - physiology ; Musculoskeletal system ; Obesity ; Pathogenesis ; Physical activity ; Primary care ; Proteins ; Quality ; Risk Factors ; Risk taking ; Sedentary behavior ; Sedentary Lifestyle ; Sensitivity analysis ; Studies</subject><ispartof>PloS one, 2013-10, Vol.8 (10), p.e78350-e78350</ispartof><rights>2013 Henson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Henson et al 2013 Henson et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-5a3f0214546d8eb1f500bf32b2ec2ef01be2b2ebba832cebb7b67dc3d84d86923</citedby><cites>FETCH-LOGICAL-c592t-5a3f0214546d8eb1f500bf32b2ec2ef01be2b2ebba832cebb7b67dc3d84d86923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812126/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812126/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24205208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Uversky, Vladimir N.</contributor><creatorcontrib>Henson, Joseph</creatorcontrib><creatorcontrib>Yates, Thomas</creatorcontrib><creatorcontrib>Edwardson, Charlotte L</creatorcontrib><creatorcontrib>Khunti, Kamlesh</creatorcontrib><creatorcontrib>Talbot, Duncan</creatorcontrib><creatorcontrib>Gray, Laura J</creatorcontrib><creatorcontrib>Leigh, Thomas M</creatorcontrib><creatorcontrib>Carter, Patrice</creatorcontrib><creatorcontrib>Davies, Melanie J</creatorcontrib><title>Sedentary time and markers of chronic low-grade inflammation in a high risk population</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Sedentary behaviour has been identified as a distinct risk factor for several health outcomes. Nevertheless, little research has been conducted into the underlying mechanisms driving these observations. This study aimed to investigate the association of objectively measured sedentary time and breaks in sedentary time with markers of chronic low-grade inflammation and adiposity in a population at a high risk of type 2 diabetes mellitus.
This study reports data from an ongoing diabetes prevention programme conducted in Leicestershire, UK. High risk individuals were recruited from 10 primary care practices. Sedentary time (<25 counts per 15 s) was measured using Actigraph GT3X accelerometers (15 s epochs). A break was considered as any interruption in sedentary time (≥25 counts per 15 s). Biochemical outcomes included interleukin-6 (IL-6), C-reactive protein (CRP), leptin, adiponectin and leptin:adiponectin ratio (LAR). A sensitivity analysis investigated whether results were affected by removing participants with a CRP level >10 mg/L, as this can be indicative of acute inflammation.
558 participants (age = 63.6±7.7 years; male = 64.7%) had complete adipokine and accelerometer data. Following adjustment for various confounders, sedentary time was detrimentally associated with CRP (β = 0.176±0.057, p = 0.002), IL-6 (β = 0.242±0.056, p = <0.001), leptin (β = 0.146±0.043, p = <0.001) and LAR (β = 0.208±0.052, p = <0.001). Associations were attenuated after further adjustment for moderate-to-vigorous physical activity (MVPA) with only IL-6 (β = 0.231±0.073, p = 0.002) remaining significant; this result was unaffected after further adjustment for body mass index and glycosylated haemoglobin (HbA1c). Similarly, breaks in sedentary time were significantly inversely associated with IL-6 (β = -0.094±0.047, p = 0.045) and leptin (β = -0.075±0.037, p = 0.039); however, these associations were attenuated after adjustment for accelerometer derived variables. Excluding individuals with a CRP level >10 mg/L consistently attenuated the significant associations across all markers of inflammation.
These novel findings from a high risk population recruited through primary care suggest that sedentary behaviour may influence markers associated with inflammation, independent of MVPA, glycaemia and adiposity.</description><subject>Accelerometers</subject><subject>Adiponectin</subject><subject>Adiponectin - metabolism</subject><subject>Adipose tissue</subject><subject>Adiposity - physiology</subject><subject>Adjustment</subject><subject>Attenuation</subject><subject>Automation</subject><subject>Biomarkers - metabolism</subject><subject>Biomedical research</subject><subject>Blood glucose</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiovascular disease</subject><subject>Chronic illnesses</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Disease control</subject><subject>Female</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Health care</subject><subject>Health risks</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - pathology</subject><subject>Insulin resistance</subject><subject>Interleukin</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - metabolism</subject><subject>Leptin</subject><subject>Leptin - metabolism</subject><subject>Lifestyles</subject><subject>Male</subject><subject>Markers</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Motor Activity - physiology</subject><subject>Musculoskeletal system</subject><subject>Obesity</subject><subject>Pathogenesis</subject><subject>Physical activity</subject><subject>Primary care</subject><subject>Proteins</subject><subject>Quality</subject><subject>Risk Factors</subject><subject>Risk taking</subject><subject>Sedentary behavior</subject><subject>Sedentary Lifestyle</subject><subject>Sensitivity analysis</subject><subject>Studies</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUstu1TAQjRCIlsIfILDEhk0ufsSPbJBQxaNSJRY8ttbEmdzrWycOdi6of0_Sm1YtYjVjz5kzZ0anKF4yumFCs3f7eEgDhM0YB9xQqo2Q9FFxymrBS8WpeHwvPyme5bynVAqj1NPihFecSk7NafHzG7Y4TJCuyeR7JDC0pId0hSmT2BG3S3HwjoT4p9wmaJH4oQvQ9zD5OMwPAmTntzuSfL4iYxwP4abyvHjSQcj4Yo1nxY9PH7-ffykvv36-OP9wWTpZ86mUIDrKWSUr1RpsWCcpbTrBG46OY0dZg0veNGAEd3PUjdKtE62pWqNqLs6K10feMcRs15Nky2otNeNU1zPi4ohoI-ztmPy83bWN4O3NR0xbC2nyLqCV0DHDgSpUptLOga5RMu6qBgWXcuF6v047ND22bj5cgvCA9GFl8Du7jb-tMIwzrmaCtytBir8OmCfb--wwBBgwHmbdVVVrNUtfZr35B_r_7aojyqWYc8LuTgyjdrHJbZddbGJXm8xtr-4vctd06wvxF1NWvDQ</recordid><startdate>20131029</startdate><enddate>20131029</enddate><creator>Henson, Joseph</creator><creator>Yates, Thomas</creator><creator>Edwardson, Charlotte L</creator><creator>Khunti, Kamlesh</creator><creator>Talbot, Duncan</creator><creator>Gray, Laura J</creator><creator>Leigh, Thomas M</creator><creator>Carter, Patrice</creator><creator>Davies, Melanie J</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131029</creationdate><title>Sedentary time and markers of chronic low-grade inflammation in a high risk population</title><author>Henson, Joseph ; Yates, Thomas ; Edwardson, Charlotte L ; Khunti, Kamlesh ; Talbot, Duncan ; Gray, Laura J ; Leigh, Thomas M ; Carter, Patrice ; Davies, Melanie J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-5a3f0214546d8eb1f500bf32b2ec2ef01be2b2ebba832cebb7b67dc3d84d86923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Accelerometers</topic><topic>Adiponectin</topic><topic>Adiponectin - metabolism</topic><topic>Adipose tissue</topic><topic>Adiposity - physiology</topic><topic>Adjustment</topic><topic>Attenuation</topic><topic>Automation</topic><topic>Biomarkers - metabolism</topic><topic>Biomedical research</topic><topic>Blood glucose</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiovascular disease</topic><topic>Chronic illnesses</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Disease control</topic><topic>Female</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Health care</topic><topic>Health risks</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - pathology</topic><topic>Insulin resistance</topic><topic>Interleukin</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henson, Joseph</au><au>Yates, Thomas</au><au>Edwardson, Charlotte L</au><au>Khunti, Kamlesh</au><au>Talbot, Duncan</au><au>Gray, Laura J</au><au>Leigh, Thomas M</au><au>Carter, Patrice</au><au>Davies, Melanie J</au><au>Uversky, Vladimir N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sedentary time and markers of chronic low-grade inflammation in a high risk population</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-10-29</date><risdate>2013</risdate><volume>8</volume><issue>10</issue><spage>e78350</spage><epage>e78350</epage><pages>e78350-e78350</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Sedentary behaviour has been identified as a distinct risk factor for several health outcomes. Nevertheless, little research has been conducted into the underlying mechanisms driving these observations. This study aimed to investigate the association of objectively measured sedentary time and breaks in sedentary time with markers of chronic low-grade inflammation and adiposity in a population at a high risk of type 2 diabetes mellitus.
This study reports data from an ongoing diabetes prevention programme conducted in Leicestershire, UK. High risk individuals were recruited from 10 primary care practices. Sedentary time (<25 counts per 15 s) was measured using Actigraph GT3X accelerometers (15 s epochs). A break was considered as any interruption in sedentary time (≥25 counts per 15 s). Biochemical outcomes included interleukin-6 (IL-6), C-reactive protein (CRP), leptin, adiponectin and leptin:adiponectin ratio (LAR). A sensitivity analysis investigated whether results were affected by removing participants with a CRP level >10 mg/L, as this can be indicative of acute inflammation.
558 participants (age = 63.6±7.7 years; male = 64.7%) had complete adipokine and accelerometer data. Following adjustment for various confounders, sedentary time was detrimentally associated with CRP (β = 0.176±0.057, p = 0.002), IL-6 (β = 0.242±0.056, p = <0.001), leptin (β = 0.146±0.043, p = <0.001) and LAR (β = 0.208±0.052, p = <0.001). Associations were attenuated after further adjustment for moderate-to-vigorous physical activity (MVPA) with only IL-6 (β = 0.231±0.073, p = 0.002) remaining significant; this result was unaffected after further adjustment for body mass index and glycosylated haemoglobin (HbA1c). Similarly, breaks in sedentary time were significantly inversely associated with IL-6 (β = -0.094±0.047, p = 0.045) and leptin (β = -0.075±0.037, p = 0.039); however, these associations were attenuated after adjustment for accelerometer derived variables. Excluding individuals with a CRP level >10 mg/L consistently attenuated the significant associations across all markers of inflammation.
These novel findings from a high risk population recruited through primary care suggest that sedentary behaviour may influence markers associated with inflammation, independent of MVPA, glycaemia and adiposity.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24205208</pmid><doi>10.1371/journal.pone.0078350</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1975712079 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Accelerometers Adiponectin Adiponectin - metabolism Adipose tissue Adiposity - physiology Adjustment Attenuation Automation Biomarkers - metabolism Biomedical research Blood glucose Body mass Body Mass Index Body size C-reactive protein C-Reactive Protein - metabolism Cardiovascular disease Chronic illnesses Cytokines Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Disease control Female Glycated Hemoglobin A - metabolism Health care Health risks Hemoglobin Humans Inflammation Inflammation - metabolism Inflammation - pathology Insulin resistance Interleukin Interleukin 6 Interleukin-6 - metabolism Leptin Leptin - metabolism Lifestyles Male Markers Medical research Medicine Metabolism Middle Aged Motor Activity - physiology Musculoskeletal system Obesity Pathogenesis Physical activity Primary care Proteins Quality Risk Factors Risk taking Sedentary behavior Sedentary Lifestyle Sensitivity analysis Studies |
| title | Sedentary time and markers of chronic low-grade inflammation in a high risk population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T16%3A01%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sedentary%20time%20and%20markers%20of%20chronic%20low-grade%20inflammation%20in%20a%20high%20risk%20population&rft.jtitle=PloS%20one&rft.au=Henson,%20Joseph&rft.date=2013-10-29&rft.volume=8&rft.issue=10&rft.spage=e78350&rft.epage=e78350&rft.pages=e78350-e78350&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0078350&rft_dat=%3Cproquest_plos_%3E1975712079%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1975712079&rft_id=info:pmid/24205208&rft_doaj_id=oai_doaj_org_article_5af182a06e6847cca79e512c4be32559&rfr_iscdi=true |